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Important medical research and remarkable case reports worth knowing.

Selected from high-relevance medical literature published in the last 14 days.

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FeaturedCase ReportOncology (Medical)

New Observations on a Low-Grade Diffusely Infiltrative Tumour, SMARCB1 Mutant, Arguing for a New Tumour Type.

Neuropathol Appl NeurobiolSep 8, 2026

This report details two cases of low-grade diffusely infiltrative tumour (LGDIT) in an 18-year-old and a 50-year-old male, both presenting with supratentorial lesions.

Clinical pearl

Clinicians should recognize the distinct histological and genetic features of low-grade diffusely infiltrative tumours, particularly the significance of SMARCB1 mutations and INI1 loss in diagnosis.

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Also worth knowing

Case ReportPathology (Anatomic & Clinical)

Non-ossifying fibroma of the proximal tibia mimicking chronic osteomyelitis in a child.

A teenage boy presented with progressive pain and swelling in the anterior left upper leg, initially suspected to be chronic osteomyelitis.

BMJ Case RepSep 4, 2026Read case
Case ReportNeurology

Astrocyte-Predominant Tau Pathology in a Patient With VCP R191Q Variant.

A Japanese woman with a heterozygous VCP R191Q variant presented with progressive muscle weakness, frontotemporal dementia, and parkinsonism, ultimately passing away at 61.

NeuropathologySep 6, 2026Open accessRead case
Case ReportPediatrics

Two-Year-Old Girl With Chronic Cough and Lymphadenopathy.

A 27-month-old girl with no significant medical history presented with a chronic cough lasting three months, accompanied by one day of fever and rhinorrhea.

PediatricsSep 1, 2026Read case

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