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1320 articles
November 202624
2025 National Guidelines on the Mediterranean Diet: Executive Summary of a Joint Report by Italian Scientific Societies and the National Institute of Health Task Force on Clinical Practice Guidelines.
This systematic review and practice guideline, developed by a multidisciplinary panel using NUTRIGRADE, assessed Mediterranean diet evidence across nine health domains and one economic domain.
Is Exercise Effective at Reducing Pain Catastrophizing in People With Chronic Nonspecific Spinal Pain? A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis examined whether exercise reduces pain catastrophizing in people with chronic nonspecific spinal pain.
Cutaneous Silent Period-Based Comparison of Dorsal Root Ganglion Pulsed Radiofrequency and Transforaminal Epidural Steroid Injection in Lumbar Radicular Pain: A Randomized Controlled Trial.
This prospective, single-blind randomized controlled trial compared dorsal root ganglion pulsed radiofrequency (DRG-PRF) with transforaminal epidural steroid injection (TFESI) in 36 patients with chronic unilateral…
Cardiovascular disease and stroke prevention educational-behavioural programmes for culturally and/or linguistically diverse communities: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed cardiovascular disease (CVD) and stroke prevention educational-behavioural programmes for people from culturally and/or linguistically diverse (CALD) backgrounds.
Clinical Reasoning: A 55-Year-Old Woman With a Hyperkinetic Movement Disorder, External Ophthalmoplegia, and Myopathy.
A 55-year-old woman was evaluated for an 8-year history of hyperkinetic movements. Her examination and clinical picture also included mild ataxia, spasticity in the lower limbs, external ophthalmoplegia, and myopathy.
Measles-like hypermutation of a Newcastle disease virus drives fatal encephalitis during BCMA × CD3 T-cell-redirecting immunotherapy.
A patient with multiple myeloma receiving maintenance teclistamab, daratumumab, and lenalidomide developed rapidly progressive brainstem-cerebellar encephalitis.
Efficacy and safety of selective orexin 2 receptor agonists in narcolepsy type 1: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis pooled randomized, double-blind, placebo-controlled trials of oral selective orexin 2 receptor agonists in people with narcolepsy type 1.
XR serious games for phantom limb pain, neurofunctional recovery, and prosthetic adoption: a systematic review.
This systematic review synthesized studies of extended-reality serious games for adults with limb amputation, examining phantom limb pain, rehabilitation, embodiment, and prosthesis adoption.
Severity-Based Triage for Direct Transportation to Nearest Comprehensive Stroke Center: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed prehospital bypass of the nearest stroke center for direct transport to a more distant comprehensive stroke center in patients with suspected stroke.
Multidisciplinary management of disseminated tuberculosis with tuberculous meningitis and active hepatitis B in a critically ill pregnant woman in the third trimester: a case report.
A 24-year-old woman at 30 weeks’ gestation presented with headache, vomiting, fever, and nuchal rigidity. Cerebrospinal fluid findings confirmed tuberculous meningitis, and chest CT showed diffuse miliary nodules…
Rheumatoid factor positivity in ANCA-negative eosinophilic granulomatosis with polyangiitis: cardiac mimicry, mononeuritis multiplex, and long-term outcome in a case-based systematic review.
A 42-year-old woman with long-standing asthma and rheumatoid factor (RF) of 322 IU/mL presented with myocardial infarction-like cardiac involvement despite non-obstructive coronary arteries.
Loberamisal for Acute Ischemic Stroke: The LAIS Randomized Clinical Trial.
The LAIS trial was a multicenter, double-blind, randomized, placebo-controlled phase 3 study at 32 hospitals in China. It enrolled adults aged 18 to 80 years with acute ischemic stroke, treated within 48 hours, and…
Brain MRI changes following continuous positive airway pressure therapy in adults with obstructive sleep apnea: a systematic review.
This systematic review synthesized longitudinal brain MRI studies in adults with obstructive sleep apnea (OSA) before and after continuous positive airway pressure (CPAP), including comparisons with control groups.
Slow-wave sleep mediates the compensatory effects of acute moderate-intensity exercise on declarative memory deficits in sleep restriction.
This randomized controlled trial tested whether one session of moderate-intensity exercise could protect declarative memory during sleep restriction and whether slow-wave sleep (SWS) mediated any benefit.
Effectiveness of guided internet-delivered cognitive behavioral therapy for insomnia in autistic adults (i-Sleep Autism): a randomized controlled trial.
This randomized controlled trial evaluated a 5-week, guided internet-delivered cognitive behavioral therapy intervention adapted for autistic adults with insomnia.
Impact of nasogastric administration using the simple suspension method on serum tirabrutinib levels: A case report.
An 82-year-old man with relapsed primary central nervous system lymphoma began tirabrutinib at 320 mg/day while fasting. As dysphagia progressed, administration changed from swallowing tablets to nasogastric delivery by…
Sex Differences in Blood Pressure Dynamics and Outcomes After Endovascular Thrombectomy.
This exploratory secondary analysis of the multicenter, open-label, blinded-end-point ENCHANTED2/MT randomized trial examined sex differences in blood pressure (BP) and outcomes among adults with acute ischemic stroke…
Pearls & Oy-sters: Anti-GABA A Receptor Encephalitis Presenting as Fulminant Hemicerebellitis in a 5-Year-Old Girl.
A previously healthy 5-year-old girl developed acute neurologic decline after several days of fever and malaise. CT showed severe right cerebellar inflammation and edema with fourth-ventricle effacement, prompting…
Clinical Reasoning: A 69-Year-Old Female Patient With Rapid-Onset Levodopa-Responsive Rest Tremor, Parkinsonism, and Gait Freezing.
A 69-year-old woman developed a unilateral resting tremor that rapidly spread to the opposite arm and then the legs. Within 3 months, she had generalized parkinsonism, a shuffling gait with prominent freezing, and…
Clinical Reasoning: A 33-Year-Old Man With Rapidly Progressive Ataxia.
A 33-year-old man with AIDS developed subacute progressive confusion, blurred vision, diplopia, and generalized cerebellar ataxia after hospitalizations for opportunistic infections.
Intractable Nausea and Vomiting: A Key Feature of Neuromyelitis Optica Spectrum Disorder.
A 22-year-old woman had five weeks of intractable nausea, vomiting, and hiccups. Delayed gastric emptying led to an initial diagnosis of gastroparesis, but symptoms persisted despite antiemetic and prokinetic therapy.
Progression-Associated Loss of SMARCB1/INI1 Expression in Mismatch Repair-Deficient Glioblastoma.
A patient with mismatch repair-deficient glioblastoma had a recurrent tumor in which testing identified a second SMARCB1 mutation and complete loss of SMARCB1/INI1 protein expression.
Vitamin D status and chemotherapy-induced peripheral neuropathy in patients with cancer: a systematic review with exploratory quantitative synthesis.
This systematic review with exploratory quantitative synthesis assessed whether serum or plasma 25-hydroxyvitamin D status was associated with chemotherapy-induced peripheral neuropathy (CIPN) in patients receiving…
Allan-Herndon-Dudley syndrome associated with SLC16A2 c.1384G>A (p.Gly462Arg): A family case report with retrospective molecular diagnosis in a deceased sibling.
A boy evaluated at 4.3 years had profound developmental delay, abnormal tone, dystonia, muscle atrophy, contractures, and bilateral cryptorchidism.
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