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Important medical research and remarkable case reports worth knowing.

Selected from high-relevance medical literature published in the last 14 days.

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FeaturedClinical ResearchGastroenterology

Proton pump inhibitors in invasively ventilated patients with SARS-CoV-2: a substudy of the re-evaluating the inhibition of stress erosions trial.

BMJ OpenAug 31, 2026Open access

This substudy of the REVISE trial evaluated the effects of pantoprazole in 532 mechanically ventilated patients with SARS-CoV-2.

Why it matters

Understanding the impact of SARS-CoV-2 on critically ill patients is crucial for managing care in ICUs. The findings suggest that while mortality is higher in infected patients, pantoprazole can be safely used without…

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Also worth knowing

Clinical ResearchGastroenterology

HBsAg decline and clearance with peg-IFN therapy added to nucleos(t)ide analogues: an individual participant data meta-analysis of prospective trials (PROSPER).

This meta-analysis evaluated the impact of peg-interferon (peg-IFN) therapy added to nucleos(t)ide analogue (NA) treatment in chronic hepatitis B patients.

GutSep 7, 2026Read summary
Clinical ResearchInfectious Diseases

Nasopharyngeal Carriage Rate, Risk Factors, and Co-Resistance Patterns of Methicillin-Resistant Staphylococcus aureus in Ethiopia: Systematic Review and Meta-Analysis.

This systematic review and meta-analysis assessed the nasopharyngeal carriage rate of methicillin-resistant Staphylococcus aureus (MRSA) in Ethiopia, analyzing 20 studies with 6869 participants.

MicrobiologyopenSep 10, 2026Read summary
Clinical ResearchInfectious Diseases

Empirical Meropenem Versus Piperacillin/Tazobactam for Critically Ill Adults With Sepsis: Feasibility of a Randomised Trial.

The EMPRESS trial is an ongoing randomized controlled trial assessing the feasibility of comparing empirical meropenem versus piperacillin/tazobactam in critically ill adults with sepsis.

Acta Anaesthesiol ScandSep 6, 2026Open accessRead summary
Clinical ResearchInfectious Diseases

Spatio-temporal trends of the prevalence of Plasmodium falciparum antimalarial drug resistance markers across sub-Saharan Africa from 2010 to 2024: a systematic review and meta-analysis.

This systematic review and meta-analysis examined the prevalence of Plasmodium falciparum antimalarial drug resistance markers across sub-Saharan Africa from 2010 to 2024.

BMC Infect DisSep 3, 2026Open accessRead summary
Clinical ResearchInfectious Diseases

Safety and Tolerability of Oral Islatravir Once Monthly as Pre-exposure Prophylaxis in Cisgender Men and Transgender Women Who Have an Elevated Likelihood of HIV-1 Exposure: Results From the IMPOWER-24 Randomized Phase 3 Study.

The IMPOWER-24 randomized Phase 3 trial evaluated the safety and tolerability of monthly oral islatravir in cisgender men and transgender women at high risk for HIV-1 exposure.

Clin Infect DisSep 2, 2026Open accessRead summary
Clinical ResearchInfectious Diseases

Comparison of Ceftolozane-Tazobactam and Ceftazidime-Avibactam in the Treatment of Multidrug-Resistant/Difficult-to-Treat Resistant Pseudomonas aeruginosa Infections: A Systematic Review and Meta-analysis.

This systematic review and meta-analysis compared the efficacy of ceftolozane-tazobactam and ceftazidime-avibactam in treating multidrug-resistant Pseudomonas aeruginosa infections.

Clin Infect DisSep 2, 2026Open accessRead summary
Clinical ResearchInfectious Diseases

Safety, Pharmacokinetics, and Pharmacodynamics of Single-Dose Programmed Cell Death Protein 1 Inhibitor, Budigalimab, in People With HIV-1 With Antiretroviral Therapy-Suppressed Viral Load.

This Phase 1b randomized controlled trial evaluated the safety, pharmacokinetics, and pharmacodynamics of single-dose budigalimab, a PD-1 inhibitor, in 32 people with HIV-1 on antiretroviral therapy.

J Infect DisSep 2, 2026Open accessRead summary
Clinical ResearchInfectious Diseases

Neutralising antibodies and protection from progression to severe COVID-19: A meta-analysis.

This meta-analysis examined the relationship between vaccine-induced neutralising antibodies and protection from severe COVID-19 in individuals with SARS-CoV-2 infection.

PLoS MedSep 2, 2026Open accessRead summary
Clinical ResearchPediatrics

Efficacy of Empirical Antibiotics in Community-Based Management of Uncomplicated Severe Acute Malnutrition in Children: Protocol of a Randomized Controlled Trial.

This randomized controlled trial aims to evaluate the efficacy of 7-day amoxicillin versus single-dose azithromycin versus no antibiotics in promoting weight gain and nutritional recovery in children aged 6-59 months…

JMIR Res ProtocSep 2, 2026Read summary
Clinical ResearchInfectious Diseases

A global overview of microsporidia infection in HIV/AIDS patients: an updated systematic review and meta-analysis.

This systematic review and meta-analysis evaluated the prevalence and species distribution of microsporidia in HIV/AIDS patients, analyzing 39 studies from 18 countries.

Int HealthSep 1, 2026Open accessRead summary
Clinical ResearchInfectious Diseases

Brief Report: Sustainability of the Effects of Linkage Case Management on Posthospitalization HIV Outcomes: The Daraja Randomized Clinical Trial.

This randomized controlled trial evaluated the sustainability of linkage case management on posthospitalization outcomes in people with HIV over 24 months.

J Acquir Immune Defic SyndrSep 1, 2026Open accessRead summary

Showing 12 of 41 publications that cleared our clinical screen in the last 14 days.

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