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Important medical research and remarkable case reports worth knowing.

Selected from high-relevance medical literature published in the last 14 days.

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FeaturedCase ReportNeurology

Time- and posture-specific management of severe supine hypertension and neurogenic orthostatic hypotension in diabetic autonomic neuropathy: A case report.

Medicine (Baltimore)Nov 6, 2026

A 63-year-old man with insulin-treated type 2 diabetes and hypertension developed worsening orthostatic dizziness and recurrent syncope after antihypertensive intensification, including a rib fracture and loss of…

Clinical pearl

Assess blood pressure across supine, seated, and standing positions and use 24-hour monitoring when orthostatic symptoms coexist with hypertension; seated readings alone may obscure the competing hemodynamic pattern.

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Also worth knowing

Case ReportMedical Genetics

Allan-Herndon-Dudley syndrome associated with SLC16A2 c.1384G>A (p.Gly462Arg): A family case report with retrospective molecular diagnosis in a deceased sibling.

A boy evaluated at 4.3 years had profound developmental delay, abnormal tone, dystonia, muscle atrophy, contractures, and bilateral cryptorchidism.

Medicine (Baltimore)Nov 6, 2026Read case
Case ReportNeurologyOpen access

Erdheim-Chester disease: a diagnostic dilemma - a report of four cases.

Four adults aged 27–40 years presented with neurological Erdheim-Chester disease (ECD), with manifestations including cerebellar ataxia, dysarthria, tremor, visual deterioration, and headache.

Neurol SciNov 5, 2026Read case
Case ReportNephrology

Vitamin D receptor activator-associated calcium-alkali syndrome-like phenotype without calcium supplementation: a case series of seven patients.

A retrospective series identified seven elderly women receiving vitamin D receptor activators who developed hypercalcemia, bicarbonate of at least 26 mmol/L, and acute kidney injury, meeting the study’s operational…

CEN Case RepNov 5, 2026Read case
Case ReportMedical GeneticsOpen access

Severe Atherogenic Dyslipidemia in Ataxia-Telangiectasia Despite Cachexia: Mechanistic Insights into Mitochondrial Dysfunction.

A 25-year-old woman with genetically confirmed ataxia-telangiectasia and extreme underweight (body mass index 12.5 kg/m²) developed severe mixed atherogenic dyslipidemia despite modest dietary fat intake and no…

Yale J Biol MedNov 4, 2026Read case
Case ReportEndocrinology

Clopidogrel-induced insulin autoimmune syndrome: A case report and analysis of clinical characteristics in Chinese patients.

A 69-year-old Chinese man developed hypoglycemic symptoms and was diagnosed with insulin autoimmune syndrome after starting clopidogrel.

J Int Med ResNov 3, 2026Read case
Case ReportEndocrinology

Proton-pump inhibitor-induced severe hypomagnesemia presenting with seizure and functional hypoparathyroidism: A diagnostic challenge in long-term acid suppression therapy.

A 68-year-old man taking omeprazole 40 mg/day for 8 years presented with a generalized tonic-clonic seizure and neuromuscular irritability.

Indian J PharmacolNov 2, 2026Read case
Case ReportEndocrinology

Tirzepatide-associated severe euvolemic hyponatremia with syndrome of inappropriate antidiuretic hormone secretion-compatible biochemical features.

A woman with type 2 diabetes and morbid obesity, taking regular insulin and chronic torsemide, developed anorexia, weakness, and drowsiness 10 days after receiving tirzepatide.

Indian J PharmacolNov 2, 2026Read case
Case ReportVascular Surgery

Orthoplastic Limb Salvage Using Transtibial Transport and Free-Flap Reconstruction in Patients With Diabetes-Related Chronic Limb-Threatening Ischemia.

A 56-year-old man with poorly controlled diabetes and severe peripheral arterial disease developed a chronic foot ulcer with toe gangrene despite unsuccessful revascularization, leaving no conventional revascularization…

J Am Acad Orthop Surg Glob Res RevNov 2, 2026Read case
Case ReportEndocrinology

Expanding the role of ivabradine in thyrotoxic crisis: a case report and Insights from the Literature.

A 39-year-old woman with alemtuzumab-induced Graves’ disease developed thyroid storm with persistent sinus tachycardia despite high-dose propranolol.

Einstein (Sao Paulo)Nov 2, 2026Read case
Case ReportPediatrics

A Neonate With Excessive Weight Loss and Electrolyte Abnormalities.

A 7-day-old girl was hospitalized for excessive weight loss. Initial testing showed hyponatremia and hyperkalemia, prompting evaluation for endocrine, renal, and metabolic causes.

PediatricsNov 1, 2026Read case
Case ReportPediatrics

Adrenal ganglioneuroma in an adolescent presenting as an incidentaloma: Imaging-pathology correlation and diagnostic challenges: A case report.

A previously healthy 16-year-old male had a right adrenal mass discovered incidentally on CT after a bicycle accident. CT and MRI showed a well-circumscribed lesion with progressive enhancement and no washout or…

Medicine (Baltimore)Nov 6, 2026Read case
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