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137 articles
November 20268
Pathophysiology Education Using a Pamphlet Among Early School-Age Children With Food Allergies: An Exploratory Pilot Controlled Study.
This non-randomized exploratory pilot controlled study assessed whether individual instruction alongside a pamphlet improved understanding of food allergy pathophysiology in 46 children in grades 1–3 undergoing oral…
Effects of intradermal lymphocyte therapy in patients with recurrent pregnancy loss: secondary analysis of a randomized controlled trial investigating purinergic signaling, inflammation, and cellular energy status.
This secondary analysis of a randomized controlled trial examined low-dose intradermal lymphocyte therapy (ILT) in 100 patients with recurrent pregnancy loss (RPL), comparing 50 treated patients with 50 receiving…
A case report of ultra-rare SMARCD2 deficiency and review of the literature.
The report describes a patient with congenital neutropenia due to specific granule deficiency type 2, a syndromic autosomal recessive disorder associated with loss-of-function variants in SMARCD2.
Sirolimus-induced improvement of immune dysregulation associated hepatosplenomegaly in common variable immunodeficiency: a case-based review.
A 50-year-old woman with common variable immunodeficiency (CVID), treated with regular intravenous immunoglobulin replacement, developed progressive hepatosplenomegaly, cytopenias, abdominal enlargement, dyspnea…
"Fatal venous thromboembolism and divergent phenotypes in DOCK8 deficiency: a three-sibling case series".
Three siblings with genetically confirmed DOCK8 deficiency had early-onset atopic dermatitis, recurrent respiratory infections, and failure to thrive. All developed bronchiectasis and severe viral infections.
Fucoidan as an anti-inflammatory and immunomodulatory agent in humans: a systematic review of clinical evidence and translational potential.
This systematic review assessed human interventional studies of fucoidan supplementation for inflammatory, immune, metabolic, and tumour-related outcomes.
Five-year outcomes of the STOP-AD randomised controlled trial: Long-term effects of early emollient therapy in high-risk infants.
This blinded, single-centre, randomised controlled trial follow-up assessed whether brief neonatal emollient use was associated with lasting effects on atopic dermatitis (AD) in term infants at high risk of AD.
Peanut Allergy and the Basophil Activation Test in the Military Healthcare System: A Case Series of Monozygotic Twins.
Two adolescent monozygotic twins in a military family had longstanding peanut-allergy labels based on positive routine allergy tests.
October 202616
Treatment-refractory chronic urticaria with neutrophilia and elevated inflammatory markers.
A 38-year-old man had long-standing chronic urticaria that persisted despite standard guideline-directed treatment. Persistent neutrophilia and elevated inflammatory markers raised concern that the presentation might…
Dengue virus controlled human challenge reveals that preexisting immunity shapes viral replication and broadly protective responses.
This phase 1 controlled human challenge trial enrolled 45 healthy adults to examine how preexisting immunity shapes responses to heterotypic dengue virus challenge.
Disruption of the N-terminal domain in a STAT3 hyper-IgE syndrome variant causes disease by sequestering STAT3 in the cytoplasm.
A patient with a STAT3 R31Q variant presented with disseminated invasive aspergillosis involving the brain and lung, bronchiectasis, and elevated serum IgE, without nonimmune manifestations of hyper-IgE syndrome.
Local Delivery of Interferon-β1a for Respiratory Viral Infections: A Systematic Review.
This PRISMA-guided systematic review assessed locally delivered intranasal or inhaled interferon-β1a for respiratory viral infections, covering clinical trials and experimental evidence.
Delayed serum sickness-like reaction mimicking septic shock after antivenom therapy: A case report.
A woman in her early 60s returned about 7 days after antivenom therapy with widespread urticarial and purpuric maculopapular rash, itching, fever, vomiting, fatigue, dizziness, hypotension, and thrombocytopenia.
Metal Hypersensitivity Reactions Following Spinal Implants: A Systematic Review.
This systematic review examined clinical presentation, diagnostic approaches, and outcomes of metal hypersensitivity after spinal implant surgery in adults.
Paediatric Helicobacter pylori infection and allergic and inflammatory diseases: a contemporary systematic review with meta-analysis.
This systematic review and meta-analysis assessed recent evidence on Helicobacter pylori infection and allergic or immune-mediated diseases in children.
Efficacy and safety of subcutaneous efgartigimod with prednisone in moderate-to-severe pemphigus (ADDRESS): a global, phase III, randomised controlled, double-blind trial.
ADDRESS was a global, phase III, multicentre, randomised, double-blind, placebo-controlled trial of adults with newly diagnosed or relapsing moderate-to-severe pemphigus.
Approach to the patient with APS-1/APECED.
This article presents five cases of autoimmune polyendocrine syndrome type 1 (APS-1/APECED), a disorder caused by impaired immune tolerance and typically associated with biallelic AIRE variants.
Serum Virus-Neutralizing Antibody Titers in Clinical Trial Participants With and Without Immunocompromise Receiving Pemivibart, a Long-Acting Monoclonal Antibody for COVID-19.
This analysis of phase 3 CANOPY and phase 1 trial data examined measured and calculated serum virus-neutralizing antibody titers after pemivibart in participants with and without significant immunocompromise.
Bee Sting-Associated Kounis Syndrome Presenting as Myocardial Infarction: A Case Report and Systematic Review with Age-Based Analysis.
A 44-year-old man presented with myocardial infarction after a probable bee sting-associated allergic reaction and was considered to have Kounis syndrome, an acute coronary syndrome linked to hypersensitivity.
Long-Term Follow-Up of Epidermolysis Bullosa Acquisita with Fluctuations in Serum Cytokine Levels: A Case Report.
A 47-year-old man with epidermolysis bullosa acquisita (EBA) had a disease course lasting more than 10 years. Serial testing showed that anti-basement membrane zone IgG and anti-type VII collagen antibody titers…
Food-Associated Kounis Syndrome: Clinical Spectrum and Diagnostic Considerations from a Case Report and Systematic Qualitative Synthesis of Published Cases.
The supplied abstract does not describe an individual patient’s presentation, diagnostic findings, or outcome. It reports a qualitative synthesis of published food-associated Kounis syndrome cases: 53 patients across 50…
Allergic bronchopulmonary mycosis associated with Talaromyces boninensis: A case report.
A patient was evaluated for allergic bronchopulmonary mycosis (ABPM), an airway hypersensitivity disorder that can be caused by fungi other than Aspergillus.
Oral deucrictibant for on-demand treatment of hereditary angioedema attacks: a phase 3, multicentre, randomised, double-blind, placebo-controlled crossover trial.
RAPIDe-3 was a phase 3, multicentre, randomised, double-blind, placebo-controlled crossover trial of oral deucrictibant for on-demand treatment of hereditary angioedema attacks.
CHAPLE-Like Enteropathy and Renal Microangiopathy in an Adult Patient With CD46 Deficiency.
A 23-year-old woman with childhood-onset enteropathy and hypogammaglobulinemia had been treated with immunoglobulin replacement for presumed common variable immunodeficiency.
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