Treatment-refractory chronic urticaria with neutrophilia and elevated inflammatory markers.

Allergy Asthma ProcOct 30, 2026
Case ReportAllergy & ImmunologyDermatology

Darshan M Sivaloganathan, Rachel M Smith, Sarbjit S Saini

✦ AI-curated · Sources linked

Case in brief

A 38-year-old man had long-standing chronic urticaria that persisted despite standard guideline-directed treatment. Persistent neutrophilia and elevated inflammatory markers raised concern that the presentation might not represent uncomplicated chronic spontaneous urticaria. Evaluation considered urticarial vasculitis, autoimmune and hematologic disease, and autoinflammatory syndromes, and included skin biopsy, expanded laboratory testing, and targeted investigations. The abstract does not report a definitive alternative diagnosis or the outcome of the evaluation.

What made this case unusual

The combination of treatment-refractory urticaria with persistent neutrophilia and elevated inflammatory markers prompted investigation for systemic mimics.

Diagnostic / clinical pearl

In persistent urticaria accompanied by systemic inflammatory features, broaden the differential beyond chronic spontaneous urticaria and investigate for potential mimics.

Source

PubMed · PMID 42952039

Published in Allergy Asthma Proc. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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