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Important medical research and remarkable case reports worth knowing.

Selected from high-relevance medical literature published in the last 14 days.

AllClinical ResearchCase Reports
FeaturedCase ReportAllergy & Immunology

Sirolimus-induced improvement of immune dysregulation associated hepatosplenomegaly in common variable immunodeficiency: a case-based review.

Rheumatol IntNov 5, 2026

A 50-year-old woman with common variable immunodeficiency (CVID), treated with regular intravenous immunoglobulin replacement, developed progressive hepatosplenomegaly, cytopenias, abdominal enlargement, dyspnea…

Clinical pearl

In CVID with progressive hepatosplenomegaly and cytopenias, evaluation should consider immune-mediated lymphoproliferation after excluding acute infection and overt lymphoma.

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Also worth knowing

Case ReportHematology

A case report of ultra-rare SMARCD2 deficiency and review of the literature.

The report describes a patient with congenital neutropenia due to specific granule deficiency type 2, a syndromic autosomal recessive disorder associated with loss-of-function variants in SMARCD2.

Immunol ResNov 5, 2026Read case
Case ReportMedical GeneticsOpen access

"Fatal venous thromboembolism and divergent phenotypes in DOCK8 deficiency: a three-sibling case series".

Three siblings with genetically confirmed DOCK8 deficiency had early-onset atopic dermatitis, recurrent respiratory infections, and failure to thrive. All developed bronchiectasis and severe viral infections.

Immunol ResNov 3, 2026Read case
Case ReportAllergy & Immunology

Peanut Allergy and the Basophil Activation Test in the Military Healthcare System: A Case Series of Monozygotic Twins.

Two adolescent monozygotic twins in a military family had longstanding peanut-allergy labels based on positive routine allergy tests.

Mil MedNov 1, 2026Read case
Case ReportAllergy & Immunology

Treatment-refractory chronic urticaria with neutrophilia and elevated inflammatory markers.

A 38-year-old man had long-standing chronic urticaria that persisted despite standard guideline-directed treatment. Persistent neutrophilia and elevated inflammatory markers raised concern that the presentation might…

Allergy Asthma ProcOct 30, 2026Read case
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