Chronic autoimmune urticaria with worsening during the luteal phase suggestive of progesterone hypersensitivity successfully treated with rituximab.
A 30-year-old woman with glucocorticoid-dependent chronic spontaneous urticaria (CSU) presented with cyclical worsening of symptoms during her luteal phase.
Clinical pearl
Clinicians should consider progesterone hypersensitivity in women with chronic spontaneous urticaria that worsens during the luteal phase.