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2000 articles
July 202624
Clinical evidence for immune cell-based therapy for head and neck cancer: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated immune cell-based therapy (ICT) in head and neck squamous cell carcinoma (HNSCC) across 30 studies involving 953 patients.
Results of intensifying radiation treatment in advanced laryngeal, hypopharyngeal (LH) and oropharyngeal cancers (OPC) using metabolic dose escalation strategies: (INTELHOPE).
This Phase II randomized controlled trial evaluated the efficacy of FDG-PET guided escalated radiation dosing (73.5 Gy) versus standard dosing (66 Gy) in patients with locally advanced p16-negative oropharyngeal and…
Ketamine for Cancer-Related Pain in Palliative Care: A Systematic Review of Clinical Use and Safety.
Ketamine has emerged as an adjuvant for opioid-refractory cancer-related pain in palliative care, but evidence remains limited.
Pembrolizumab-Chemotherapy Versus Pembrolizumab in Head and Neck Squamous Cell Carcinoma: A PD-L1 CPS-Stratified Analysis of Updated KEYNOTE-048 Data.
This randomized controlled trial analyzed updated data from KEYNOTE-048 to compare the efficacy of pembrolizumab-chemotherapy versus pembrolizumab monotherapy in patients with recurrent/metastatic head and neck squamous…
Fertility-Sparing Treatment of Women With Endometrial Carcinoma With Myometrial Invasion: Pooled Estimates of Response From a Systematic Review and Meta-Analysis.
This systematic review and meta-analysis pooled outcomes of fertility-sparing conservative treatment for endometrial carcinoma with myometrial invasion.
Metastatic Large Cell Calcifying Sertoli Cell Tumor: A Case Report, Diagnostic Pitfalls, and Literature Review.
A 37-year-old man developed testicular pain and swelling after trauma and was initially treated for epididymitis and hydrocele.
The clinical utility of magnetic resonance elastography in differentiating tumor recurrence from pseudoprogression in glioblastoma.
Glioblastoma (GBM) is the most common malignant primary brain tumor in adults with nearly universal progression despite aggressive treatment.
Preclinical evidence for cytokine-based immunotherapy in pancreatic cancer treatment: A systematic review.
This systematic review assessed cytokine-based immunotherapy for pancreatic cancer, analyzing 46 preclinical studies. It found that targeting cytokines like TGF-β and IL-6 improved stromal remodeling, while…
Phase III Study of Niraparib Plus Pembrolizumab as Maintenance Therapy for Advanced or Metastatic NSCLC (ZEAL-1L).
ZEAL-1L was a randomized, double-blind, multicentre phase III trial of maintenance niraparib plus pembrolizumab versus placebo plus pembrolizumab in adults with advanced or metastatic squamous or nonsquamous NSCLC…
From center to edge: Prognostic implications of spatial metabolic heterogeneity, normalized hotspot-to-centroid and perimeter distance, on PET imaging. A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the prognostic value of PET-derived spatial radiomic features, specifically normalized hotspot-to-centroid (NHOC) and normalized hotspot-to-perimeter (NHOP) distances…
Inconsistent definitions of local control for stereotactic body radiation therapy for early-stage lung cancer - A systematic review.
This systematic review examined the definitions and assessments of local control (LC) following stereotactic body radiation therapy (SBRT) for early-stage non-small cell lung cancer (NSCLC).
Quality of life and cost-effectiveness of preoperative accelerated versus postoperative conventional radiotherapy for oral cavity cancer: Results from the randomised ARTSCAN 2 trial.
The ARTSCAN 2 randomized controlled trial evaluated the health-related quality of life (HRQoL) and cost-effectiveness of preoperative accelerated fractionation (AF) radiotherapy versus postoperative conventional…
Altered Busulphan Exposure Associated with Concomitant Omeprazole during Hematopoietic Stem Cell Transplantation Conditioning: A Two-Case Report.
Two adult patients with acute myeloid leukemia underwent conditioning with oral busulphan prior to hematopoietic stem cell transplantation.
Intracholecystic Papillary Neoplasm Mimicking High-Grade Dedifferentiation in a Patient With Neuroendocrine Tumor: The Value of Dual-Tracer PET/CT.
A 50-year-old man with weight loss and fatigue was diagnosed with a grade 2 pancreatic neuroendocrine tumor with liver metastases.
Assessing time to symptomatic progression, a patient-relevant efficacy endpoint, in the MARIPOSA study in non-small cell lung cancer.
The phase 3 MARIPOSA study evaluated the efficacy of amivantamab and lazertinib versus osimertinib in patients with untreated, EGFR-mutated advanced non-small cell lung cancer.
Long-term outcomes and exploratory analysis from a randomized phase 3 trial of radiation dose escalation in definitive chemoradiotherapy for locally advanced esophageal squamous cell carcinoma.
This randomized phase 3 trial evaluated the long-term outcomes of radiation dose escalation (60 Gy vs 50 Gy) in 324 patients with locally advanced esophageal squamous cell carcinoma (ESCC).
Randomized phase-II trial of surufatinib plus FOLFOX/FOLFIRI versus FOLFOXIRI as second-line therapy for metastatic colorectal cancer.
This randomized phase-II trial evaluated the efficacy and safety of surufatinib combined with doublet (FOLFOX/FOLFIRI) versus triplet (FOLFOXIRI) chemotherapy in patients with metastatic colorectal cancer (mCRC) who…
Aspirin for cancer prevention in individuals with Lynch syndrome: first results from the CaPP3 multicentre, randomised, double-blind, non-inferiority trial.
The CaPP3 trial evaluated the efficacy of lower doses of aspirin (100 mg and 300 mg daily) compared to 600 mg daily in preventing Lynch syndrome cancers among 1866 participants with Lynch syndrome.
Comparative Efficacy of Non-opioid Analgesic Drugs for Chronic Cancer Pain: A Bayesian Network Meta-analysis.
This Bayesian network meta-analysis evaluated the efficacy of non-opioid analgesics for chronic cancer pain in 1845 patients across 23 randomized controlled trials.
The impact of maternal breast cancer diagnosis on the mother-child relationship: an updated systematic review.
This systematic review updated previous findings on the impact of maternal breast cancer diagnosis on mother-child relationships, analyzing 68 studies.
Autophagy potential of polyphenols in breast carcinoma: A systematic review.
This systematic review evaluated the effects of polyphenols on autophagy in breast cancer, analyzing 48 studies, including 40 in vitro and 8 in vivo.
A Systematic Review and Meta-Analysis of Surgical Feasibility and Outcomes Following Neoadjuvant Immune Checkpoint Inhibition in Resectable Stage III and IV Melanoma.
This systematic review and random-effects meta-analysis assessed oncologic and perioperative outcomes after neoadjuvant immune checkpoint inhibition (ICI) followed by planned curative-intent surgery in adults with…
Impact of R0/R1 Margin Status on Overall Survival in Node-Positive Resected Pancreatic Ductal Adenocarcinoma: Meta-Analysis.
This meta-analysis examined the impact of R0 versus R1 margin status on overall survival in 19,206 patients with node-positive resected pancreatic ductal adenocarcinoma (PDAC).
Dose Optimization of Dasatinib in Chronic-Phase Chronic Myeloid Leukemia: A Systematic Review and Meta-analysis of 50 mg Versus 100 mg Once Daily.
This systematic review and meta-analysis evaluated the efficacy and safety of dasatinib 50 mg versus 100 mg once daily in adults with chronic-phase chronic myeloid leukemia (CP-CML).
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