From center to edge: Prognostic implications of spatial metabolic heterogeneity, normalized hotspot-to-centroid and perimeter distance, on PET imaging. A systematic review and meta-analysis.

Eur J Nucl Med Mol ImagingJul 10, 2026 (epub)
Clinical ResearchOncology (Medical)Open access

Sajjad Sadeghpour, Ramin Sadeghi, Atena Aghaee et al.

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In 30 seconds

This systematic review and meta-analysis evaluated the prognostic value of PET-derived spatial radiomic features, specifically normalized hotspot-to-centroid (NHOC) and normalized hotspot-to-perimeter (NHOP) distances, in cancer patients. The analysis included 1,496 patients across ten studies, revealing that elevated NHOC was significantly associated with worse overall survival (HR of 2.313, 95% CI [1.418, 3.775], p = 0.001).

Key findings

  • Elevated NHOC was associated with worse overall survival (HR of 2.313, 95% CI [1.418, 3.775], p = 0.001).
  • In lung cancers, NHOC showed a strong association with overall survival (HR of 2.864, 95% CI [2.018, 4.063], p < 0.001).
  • NHOP decrease indicated a non-significant trend toward poorer progression-free survival (HR = 2.92, 95% CI: 0.71-11.92).
  • Predictive models based on NHOC demonstrated moderate performance with an AUC up to 0.77.

Why it matters

Understanding tumor heterogeneity through PET-derived biomarkers like NHOC can enhance prognostic assessments in oncology, potentially guiding treatment decisions and improving patient outcomes.

Source

PubMed · PMID 42429822Free full text on PubMed Central

Published in Eur J Nucl Med Mol Imaging. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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