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845 articles
October 202624
Targeted BRAF /MEK inhibition as a salvage therapy for patients with metastatic melanoma harboring a BRAF L597R mutation: two case reports and review of the literature.
Two patients with metastatic melanoma harboring the BRAF L597R mutation had rapid clinical deterioration and disease progression after dual immune checkpoint inhibition.
Post-transplant BRAF/MEK inhibitor maintenance sustains complete remission in BRAF V600E-mutant histiocytic sarcoma.
A patient with refractory BRAF V600E-mutant histiocytic sarcoma achieved complete remission with BRAF/MEK inhibition and then underwent allogeneic stem cell transplantation.
Vaginal Angiomyofibroblastoma in a Patient With Warkany Syndrome (Mosaic Trisomy 8): A Case Report.
A 27-year-old nulliparous woman with constitutionally confirmed mosaic trisomy 8 presented with a protruding vaginal mass. MRI showed a well-defined, homogeneously enhancing mid-vaginal lesion and incidentally…
Rare and Novel Hepatitis C Virus Genotype Subtypes and Response to Sofosbuvir/Velpatasvir in A5360 (MINMON) Clinical Trial.
This analysis of samples from the multicountry ACTG A5360 (MINMON) clinical trial characterized rare and novel hepatitis C virus (HCV) subtypes and assessed baseline resistance-associated substitutions and response to…
Protein-losing enteropathy as a rare presentation of small bowel T-cell post-transplant lymphoproliferative disease.
A kidney transplant recipient developed episodic diarrhea, with initial investigations showing no bowel pathology. She later developed fluid retention associated with hypoalbuminemia, and technetium-99m human serum…
Testis-Sparing Surgery for Multiple Fibrous Pseudotumors of the Epididymis: A Case Report.
A 44-year-old man had multiple firm, nontender left epididymal nodules. Ultrasound showed hypoechoic lesions without testicular invasion, and tumor markers were negative.
Long-term consequences in RAS blocker-induced fetopathy with multiorgan impairments.
A girl with fetopathy after maternal exposure to a renin–angiotensin system blocker was followed for 10 years. She had severe short stature and persistent mild developmental delay; cranioplasty at 1 year revealed right…
Sialadenopapillary Ductal Tumor: Case Series and Review of the Literature.
The authors describe three patients with sialadenopapillary ductal tumors, a rare neoplasm of likely minor salivary gland origin characterized by prominent submucosal ductal proliferation and multilayered cystic…
Oxalate Nephropathy in a patient with Neuroendocrine tumor receiving Long-acting Octreotide.
A 55-year-old man with metastatic somatostatin receptor-positive neuroendocrine tumour received long-acting octreotide and, later, four cycles of 177 Lu-DOTA-TATE peptide receptor radionuclide therapy (PRRT).
Intracardiac thrombus and multiple venous thromboses revealing focal segmental glomerulosclerosis.
A 51-year-old woman presented with two weeks of lower-limb edema and hematuria. Imaging showed lower-extremity deep vein thrombosis, partial left renal vein thrombosis, and a 23 × 20 mm left ventricular thrombus.
Previously Unrecognized Distinct Laryngeal Lesions During Lazertinib Therapy in EGFR-Mutated NSCLC: A Case Series.
Four patients with non-small cell lung cancer developed new voice changes or a globus sensation while receiving lazertinib-based therapy.
Multicentric reticulohistiocytosis in children: two case reports and a literature review.
The report describes two boys with multicentric reticulohistiocytosis (MRH), a disorder uncommon in children and liable to be mistaken for juvenile idiopathic arthritis.
Tricuspid Chordae Tendineae Rupture Detected After Repair of a Delayed Traumatic Left Ventricular Aneurysm: A Case Report.
After a fall from a height, a patient presented 54 days later with rupture of a posterior left ventricular aneurysm. Venoarterial extracorporeal membrane oxygenation provided circulatory support before surgical aneurysm…
Fatal Rickettsia parkeri Rickettsiosis in Immunocompromised Pediatric Patient, Georgia, USA, 2025.
A 3-year-old boy in Georgia, USA, receiving chemotherapy for B-cell acute lymphoblastic leukemia was hospitalized with febrile neutropenia.
Acquired Corneal Subepithelial Hypertrophy: First Ultrastructural Characterization by Transmission Electron Microscopy.
A 57-year-old man with prior penetrating keratoplasty for trauma and subsequent Descemet stripping automated endothelial keratoplasty developed progressive visual decline from a superficial corneal opacity.
HHV8-associated multicentric Castleman disease with Kaposi sarcoma in an immunocompetent patient: a case report and review of the literature.
A 57-year-old man presented with five months of generalized lymphadenopathy, weakness, cough, fever, and weight loss. HIV, CMV, EBV, and tuberculosis tests were negative.
Copy number variants across the developmental epilepsy-developmental and epileptic encephalopathy spectrum: an Indonesian case series.
A retrospective series from a tertiary hospital in Yogyakarta described four Indonesian children with developmental epilepsy or developmental and epileptic encephalopathy and pathogenic copy number variants.
Successful treatment with BrECADD in a patient with Dubin-Johnson syndrome and classic Hodgkin lymphoma: a case report.
A 26-year-old man with advanced-stage classic Hodgkin lymphoma also had Dubin–Johnson syndrome (DJS) associated with a homozygous ABCC2 variant, c.2291G>A (p.Gly764Asp).
Anatomopathological Aspects and Clinical Correlation of Conjunctival Bleb Fibrosis Following Encapsulation of a Biodegradable Collagen Matrix Implant in Glaucoma Surgery.
Four patients with progressive glaucoma and inadequate intraocular pressure control despite maximal medical therapy underwent non-penetrating deep sclerectomy with a biodegradable collagen-glycosaminoglycan implant and…
Primary renal diffuse large B cell lymphoma misdiagnosed as renal cell carcinoma: A case report.
A 78-year-old man presented with 2 weeks of right flank pain radiating to the abdomen; examination was unremarkable. Tests showed mildly elevated lactate dehydrogenase and occult blood in the urine.
Primary tubal choriocarcinoma with extrauterine implantation masquerading as ectopic pregnancy: A case report and literature review.
A 29-year-old woman with irregular menses had extremely high β-human chorionic gonadotropin levels and ultrasonographic findings suggestive of ectopic pregnancy.
A case report of thyroid sarcomatoid carcinoma.
A 65-year-old man presented with fever and left-sided neck pain; examination found a hard mass in the left thyroid lobe. Ultrasound showed a hypoechoic nodule with an anterior-posterior-to-transverse diameter ratio >1…
Isolated necrotizing scleritis revealing silent pulmonary granulomatosis with polyangiitis: A case report of rare diagnostic clue.
A 31-year-old man with recurrent unilateral necrotizing anterior scleritis that resisted corticosteroids and immunosuppressants had no systemic symptoms.
Bing-Neel syndrome successfully treated with venetoclax and zanubrutinib: A case report and review of the literature.
A 66-year-old woman with Waldenström macroglobulinemia presented with headache and was diagnosed with Bing-Neel syndrome after cerebrospinal fluid examination. She received zanubrutinib with venetoclax.
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