Multicentric reticulohistiocytosis in children: two case reports and a literature review.

Clin RheumatolOct 26, 2026 (epub)
Case ReportPediatricsRheumatologyDermatologyPathology (Anatomic & Clinical)Open access

Chenxi Liu, Liping Wang, Hua Huang et al.

✦ AI-curated · Sources linked

Case in brief

The report describes two boys with multicentric reticulohistiocytosis (MRH), a disorder uncommon in children and liable to be mistaken for juvenile idiopathic arthritis. A 10.8-year-old presented with polyarthritis, coral-bead-like papules and subcutaneous nodules. A 14-year-old, previously diagnosed with systemic-onset JIA complicated by macrophage activation syndrome, had persistent atypical pruritic rashes despite conventional and biologic therapies. Skin biopsies confirmed MRH in both cases. Tofacitinib was reported to alleviate symptoms.

What made this case unusual

The diagnostic challenge was recognizing MRH in children, including in a boy whose prior JIA diagnosis and treatment had not accounted for persistent atypical skin lesions.

Diagnostic / clinical pearl

In a child with arthritis and atypical or coral-bead-like skin lesions, consider MRH and use skin biopsy to investigate; histopathology was key to confirmation in these cases.

Source

PubMed · PMID 42932089Free full text on PubMed Central

Published in Clin Rheumatol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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