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1320 articles
August 202624
Neurological effects of encapsulated dexamethasone sodium phosphate in children aged 6-9 years with ataxia telangiectasia (NEAT): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.
The NEAT trial was a multicentre, randomised, double-blind, placebo-controlled phase 3 study assessing the efficacy and safety of encapsulated dexamethasone sodium phosphate (eDSP) in children aged 6-9 years with ataxia…
Uncommon Concurrent Retinal and Cerebral Metastasis in High-risk Neuroblastoma: Diagnostic Utility of 68Ga-DOTATATE PET/CT Despite Negative 18F-FDG PET/CT.
A 5-year-old girl with high-risk neuroblastoma presented for surveillance with an 18F-FDG PET/CT, which showed two metabolically silent lesions in the right retina and brain.
Biallelic SLC20A2 loss-of-function in severe early-onset neurodevelopmental disorder with brain calcification.
A child presented in early infancy with refractory seizures, severe hypotonia, left hemiplegia, profound developmental impairment, bilateral cataracts, and progressive intracranial calcification.
Noncommunicating Hydrocephalus in an Human Immunodeficiency Virus-positive Male: A Diagnostic Challenge.
A 43-year-old man living with HIV presented with progressive memory loss. Evaluation identified moderate noncommunicating hydrocephalus.
Long-Term Effects of Kangaroo Mother Care on Neuromotor Development in Adults Born Preterm: A Transcranial Magnetic Stimulation Study.
This cohort analysis followed 214 young adults born weighing ≤ 1800 g who had originally participated in a randomized trial of Kangaroo Mother Care (KMC) versus conventional neonatal care.
Downbeat nystagmus: a practical approach based on a clinical case.
Spontaneous downbeat nystagmus (DBN) is the most common form of acquired nystagmus, characterized by a slow upward ocular drift and a corrective downward quick phase.
Fulminant cryptococcal meningoencephalitis with adrenal involvement in an immunocompetent patient: a clinicopathologic correlation.
A 65-year-old immunocompetent man presented with severe headache, psychomotor agitation, confusion, and disorganized speech.
A 4-year-old male presenting with frequent falls, clumsily rising from seated positions, but a normal creatine kinase.
A 4-year-9-month-old boy had progressive gait instability, frequent falls, mild coordination impairment, and difficulty rising.
Individualized vs Standard Blood Pressure Control During Thrombectomy for Ischemic Stroke: The DETERMINE Randomized Clinical Trial.
The DETERMINE randomized clinical trial evaluated individualized blood pressure (BP) control during mechanical thrombectomy for ischemic stroke in 433 patients.
Heterogeneity in Teriflunomide Treatment Arms: A Systematic Review and Meta‑Regression of Randomised Multiple Sclerosis Trials.
This systematic review and meta-analysis examined temporal trends in relapse and disability outcomes in teriflunomide arms of Phase 3 trials for relapsing multiple sclerosis (RMS).
Comparative Efficacy of Specific Exercise Interventions on Post-Stroke Depression, Anxiety and Cognitive Function in Older Adults: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.
This systematic review and network meta-analysis compared exercise interventions for depression, anxiety, and cognitive function in older adults with stroke, drawing on 52 randomized controlled trials involving 4,170…
Effects of Escitalopram on Neuropsychiatric Symptoms in Alzheimer Disease: A Secondary Analysis From the S-CitAD Study.
This secondary, exploratory analysis of the randomized S-CitAD trial examined neuropsychiatric symptoms beyond agitation in 173 people with Alzheimer disease assigned to escitalopram (5–15 mg/day) or placebo.
Guillain-Barré syndrome complicated by myocarditis and acute kidney injury after maltose-based IVIG treatment: A case report.
A 41-year-old man with diabetes and acute inflammatory demyelinating polyradiculoneuropathy received maltose-based intravenous immunoglobulin (IVIG).
Safe administration of botulinum neurotoxin type A for facial nerve palsy sequelae in a patient with myasthenia gravis.
A woman in her 40s with a 10-year history of generalized, seronegative myasthenia gravis presented with facial tightness and mild synkinesis due to facial nerve palsy sequelae.
Two Japanese Cases Highlighting Structural and Phenotypic Overlap in AGO1- and AGO2-Related Neurodevelopmental Disorders.
Two unrelated Japanese individuals presented with global developmental delay, hypotonia, midface hypoplasia, thin upper lip, elongated facial shape, and reduced cerebral white matter volume.
Peroxisomal disorder associated with ACOX1 gain-of-function mimicking neuroinflammatory disease.
A 6-year-old girl presented with motor delay, ichthyosiform eczema, gait disturbance, pain, weakness, areflexia, hypomimia, and hearing loss.
Efficacy of intravenous ketamine for neuropathic pain: a systematic review and meta-analysis of randomized clinical trials.
This systematic review and meta-analysis assessed intravenous ketamine versus placebo for chronic neuropathic pain in adults.
Clinical efficacy and brain mechanism characteristics of guide chi and regulate spirit tuina therapy in the treatment of post-stroke walking dysfunction: A randomized controlled trial based on fNIRS.
This randomized controlled trial evaluated the efficacy of Guide Chi and Regulate Spirit (GCRS) Tuina therapy in improving walking function among post-stroke patients with walking dysfunction.
Effectiveness of hyperbaric oxygen in traumatic brain injury patients: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effectiveness of hyperbaric oxygen therapy (HBOT) in adults with traumatic brain injury (TBI).
Parkinsonism as a Potential Neurologic Immune-Mediated Adverse Event of Immune Checkpoint Inhibitors.
Immune checkpoint inhibitor (ICI)-related parkinsonism is an exceedingly rare neurologic immune-related adverse event (irAE).
Intramuscular midazolam versus intravenous clonazepam for prehospital treatment of generalized tonic-clonic seizures: A randomized double-blind non-inferiority trial.
This randomized double-blind non-inferiority trial evaluated the efficacy of intramuscular (IM) midazolam versus intravenous (IV) clonazepam for prehospital treatment of generalized tonic-clonic seizures in patients…
Defining a Clinically Meaningful Within-Person Change Threshold for the Psychomotor Vigilance Test in Narcolepsy Type 1.
This analysis of two randomized, placebo-controlled phase III trials established a meaningful within-person change threshold for Psychomotor Vigilance Test (PVT) lapses and assessed attention changes in people with…
Rapid clinical stabilization following eculizumab therapy in severe anti-NMDAR encephalitis.
A young patient with severe anti-NMDAR encephalitis developed seizures, psychiatric and behavioral symptoms, dyskinesia, and dysautonomia.
Multimodal circadian phenotyping reveals distinct mechanisms of photic entrainment failure in two sighted patients with non-24-hour sleep-wake disorder.
Two sighted patients with non-24-hour sleep-wake disorder (N24SWD) underwent extensive circadian phenotyping to explore mechanisms of photic entrainment failure.
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