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937 articles
June 202624
Body mass index, adjuvant chemotherapy, toxicity, and survival in non-metastatic colorectal cancer: an individual participant data meta-analysis (OCTOPUS).
This individual participant data meta-analysis examined the relationship between body mass index (BMI) and survival in 7264 patients with non-metastatic colorectal cancer undergoing adjuvant chemotherapy.
Unmasking Hyperammonemia: Psychomotor Slowing as a Diagnostic Trigger During PEG and Enteral Nutrition.
A 63-year-old woman experienced severe hyperammonemia and psychomotor slowing after undergoing percutaneous endoscopic gastrostomy (PEG) and continuous enteral nutrition for anxiety-related feeding difficulties.
Physician-Patient Discordance in Bristol Stool Scale Classification and Overall IBS Burden Assessment.
This post hoc analysis of a randomized trial compared patient-reported and physician-assessed Bristol Stool Form Scale (BSFS) classifications in people with irritable bowel syndrome (IBS), alongside symptom severity and…
Vertical Sleeve Gastrectomy Versus Comprehensive Lifestyle Intervention for Adolescents With Metabolic Dysfunction-Associated Steatotic Liver Disease: A Prospective Controlled Cohort Study.
This prospective controlled cohort study compared the effects of vertical sleeve gastrectomy (VSG) and comprehensive lifestyle intervention (CLI) on adolescents aged 12-19 with severe obesity and metabolic…
Orbital manifestations of inflammatory bowel disease - a systematic review.
Extra-intestinal manifestations of inflammatory bowel disease (IBD) occur in 25-40% of patients; however, orbital involvement is rare and underreported.
The Efficacy of Dexamethasone Versus N-Acetylcysteine in Prevention of Post-Embolization Syndrome in Hepatocellular Carcinoma Patients: A Multicenter Randomized, Double-Blind, Double-Dummy, Non-Inferiority Trial.
This Phase 3, multicenter, randomized, double-blind, double-dummy non-inferiority trial compared a single intravenous 8 mg dose of dexamethasone (DEX) with N-acetylcysteine (NAC) to prevent post-embolization syndrome…
Comparative efficacy of advanced preservation strategies for donation after circulatory death liver grafts: A systematic review and network meta-analysis.
This systematic review and Bayesian network meta-analysis compared preservation strategies for donation after circulatory death (DCD) liver grafts across 19 comparative studies identified through June 2025.
A Stomach Neuroendocrine Carcinoma With CCNE1 Amplification: A Case Report and Brief Review of Literature.
The report describes a patient with a gastric neuroendocrine carcinoma whose morphology and molecular alterations were ambiguous, raising the diagnostic challenge of distinguishing poorly differentiated neuroendocrine…
Evidence on the impact of treatment optimization on the safety of patients with liver cirrhosis.
This systematic review assessed whether optimizing medication therapy improves medication-related safety in people with liver cirrhosis.
Confirmation of a Biliothoracic Fistula With Dynamic [ 68 Ga]Ga-TEoS-DAZA-PET/CT.
A critically ill patient developed a suspected biliothoracic fistula after a perforated gastric ulcer repair. Dynamic hepatobiliary PET/CT using [68Ga]Ga-TEoS-DAZA successfully visualized bile flow, revealing leakage…
Endoscopic Ultrasound-Guided Versus Transjugular Portal Pressure Measurements: Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the correlation between endoscopic ultrasound-guided portal pressure gradient (EUS-PPG) and invasive hemodynamic measurements in six prospective cohorts.
Efficacy and Safety of Pembrolizumab in Advanced Gastric Cancer: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the efficacy and safety of pembrolizumab in 4,560 patients with advanced gastric cancer.
Complementary use of white-light endoscopy and narrow-band imaging for postendoscopic mucosal resection scar assessment: a systematic review and diagnostic meta-analysis.
This systematic review and diagnostic meta-analysis assessed white-light endoscopy (WLE) and narrow-band imaging (NBI) for detecting recurrence at colorectal endoscopic mucosal resection (EMR) scars during surveillance…
Impact of Availability of Computer-Aided Detection Devices on Adenoma Detection During Colonoscopy: A Cluster Randomized Study.
This pragmatic, multicentre cluster-randomised quality improvement study assessed whether making computer-aided detection (CADe) devices available affected adenoma detection during colonoscopy at Veterans Health…
The role of exosomal microRNAs in detecting hepatocellular carcinoma: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the diagnostic performance of exosomal microRNAs (miRNAs) in detecting hepatocellular carcinoma (HCC) among 1442 HCC patients, 761 healthy controls, and 1091 chronic…
Late hiatal hernia after Roux-en-Y gastric bypass: a systematic review.
This systematic review examined late hiatal hernia (HH) after Roux-en-Y gastric bypass (RYGB) in patients with obesity. The study found that HH is associated with gastroesophageal reflux disease (GERD) in 39-93.6% of…
Severe cytomegalovirus gastritis and hypogammaglobulinemia in a patient treated with pembrolizumab.
A 66-year-old man with stage IVB oesophageal carcinoma, treated with pembrolizumab, presented with gastric erosions and ulcers.
Evenly Distributing Daily Dietary Protein Across Three Meals Reduces Women's Snack Food Reinforcement and Intake of Energy-Dense Snack Foods During Weight Loss: A Randomized Controlled Trial.
This randomized controlled trial examined the impact of protein distribution on snack food reinforcement and intake among healthy women aged 20 to 44 with a BMI of 28 to 45.
Learning and deskilling effects of artificial intelligence in colonoscopy among endoscopists with different levels of experience: a pragmatic, prospective trial.
This pragmatic, multicenter trial evaluated the impact of computer-aided detection (CADe) on polyp detection rates (PDR-5) among 13 endoscopists with varying experience levels.
Rotational thromboelastometry versus conventional tests in decompensated cirrhotic children undergoing invasive procedures.
This randomized controlled trial evaluated the efficacy of a ROTEM-guided transfusion strategy in children aged 6 months to 18 years with decompensated cirrhosis undergoing invasive procedures.
Prognostic Value of Circulating Tumor DNA-Based Minimal Residual Disease for Recurrence-Free Survival in Resectable Gastric Cancer: A Systematic Review and Meta-Analysis with Serial Monitoring Analysis.
This systematic review and meta-analysis evaluated the prognostic value of circulating tumor DNA (ctDNA)-based minimal residual disease (MRD) in 520 patients with resectable gastric cancer.
A phase 1 study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of PF-07261271 in healthy participants.
This phase 1 randomized controlled trial evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of PF-07261271, a bispecific antibody, in 35 healthy participants.
Gut microbiome dysbiosis and cancer: A systematic review on the emerging role of probiotics in oncology.
This systematic review evaluated the impact of probiotic supplementation in cancer patients, focusing on its clinical effects.
Sudden Acute Liver Failure in Citrullinemia Type 1: An Argument for Earlier Liver Transplantation?
This report details a case of a child with citrullinemia type 1 who presented with sudden acute liver failure. Despite medical management, the child experienced recurrent hepatic decompensations, ultimately…
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