A phase 1 study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of PF-07261271 in healthy participants.

Br J Clin PharmacolJun 3, 2026 (epub)

Srividya Neelakantan, Christopher Banfield, Kenneth Hung et al.

✦ AI-curated · Sources linked

In 30 seconds

This phase 1 randomized controlled trial evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of PF-07261271, a bispecific antibody, in 35 healthy participants. The study found that PF-07261271 was generally safe and well tolerated, with all treatment-emergent adverse events classified as mild to moderate. Notably, the estimated bioavailability for the subcutaneous administration was 48%.

Key findings

PF-07261271 was generally safe and well tolerated, with all adverse events mild to moderate.
The estimated bioavailability of PF-07261271 administered subcutaneously was 48%.
Dose-dependent increases in serum total sTL1A and p40 levels indicated target engagement.

Why it matters

The study highlights the potential of PF-07261271 as a new therapeutic option for inflammatory bowel disease, addressing the need for more effective treatments that target multiple pathways.

Source

PubMed · PMID 42235928

Published in Br J Clin Pharmacol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

ShareTelegram LinkedIn

AI-generated summaries may contain errors or omissions. Verify clinically important information with the original publication.

More in Gastroenterology

Clinical ResearchPreventive Medicine / Public Health

2025 National Guidelines on the Mediterranean Diet: Executive Summary of a Joint Report by Italian Scientific Societies and the National Institute of Health Task Force on Clinical Practice Guidelines.

This systematic review and practice guideline, developed by a multidisciplinary panel using NUTRIGRADE, assessed Mediterranean diet evidence across nine health domains and one economic domain.

Nutr RevNov 12, 2026Read summary

Clinical ResearchOrthopedic Surgery

Prevention of Venous Thromboembolism after Total Hip or Knee Replacement.

This multicenter randomized comparative-effectiveness noninferiority trial compared 30 days of aspirin, warfarin, or rivaroxaban for VTE prophylaxis after elective total hip or knee arthroplasty.

N Engl J MedNov 12, 2026Read summary

Clinical ResearchAnesthesiology

Effect of discontinuing antihypertensives on perioperative hypotension in older patients before non-cardiac surgery: multicentre, randomised, double blind, controlled trial.

This multicentre, randomised, double blind, placebo controlled trial assessed whether withholding ACE inhibitors or ARBs on the morning of surgery reduces perioperative hypotension in older adults undergoing non-cardiac…

BMJNov 11, 2026Read summary

Want this personalized?

Stop searching the literature. Choose what you follow and xxcode will build your personalized medical digest.

Your specialties
Your filters and thresholds
Clinical Research + Case Reports, tuned separately
Automatic weekly delivery
Audio and text

Create my personalized digest See plans

Prefer listening? Personalized audio digests are available with Pro.

Stay updated for free

Get the 3 most interesting publications in one specialty each week.

Weekly email. Unsubscribe anytime.