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154 articles
October 202610
Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis.
This individual participant data meta-analysis examined amyloid PET scans from 49,227 participants across 53 studies to establish Centiloid positivity cutoffs for Alzheimer disease diagnosis.
¹⁸F-sodium fluoride PET/CT as a complementary measure of osteoblastic disease burden in axial spondyloarthritis: a prospective exploratory study.
This prospective exploratory imaging study assessed whether sacroiliac joint (SIJ) ¹⁸F-sodium fluoride PET/CT could complement MRI in 43 adults with chronic low back pain classified as radiographic axial…
Primary pulmonary mucosa-associated lymphoid tissue lymphoma presenting as a right hilar mass: A case report.
A 44-year-old male presented with an incidental right hilar mass discovered during routine screening. He was asymptomatic, and imaging revealed a 3.9 × 3.5 cm mass causing bronchial compression and post-obstructive…
First-in-human dosimetry and biodistribution of [ 89 Zr]Zr-oxine-labeled autologous leukocytes using PET/CT.
This prospective first-in-human clinical trial evaluated the safety, biodistribution and radiation dosimetry of [89Zr]Zr-oxine-labeled autologous leukocytes in four healthy adult women.
Clinical Trial Protocol for LPS-Boost: Intensified [ 177 Lu]Lu-PSMA-617 Treatment for Patients with Metastatic Castration-Resistant Prostate Cancer with Low PSMA-Expressing Disease.
This multicenter, open-label phase 2 trial investigates an intensified treatment schedule of [177Lu]Lu-PSMA-617 for 45 patients with metastatic castration-resistant prostate cancer (mCRPC) and low PSMA expression.
Tumor and Organ Dose Estimates from 177 Lu-PSMA-617 Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer: Results from the RESIST-PC Phase 2 Trial.
The RESIST-PC Phase 2 trial assessed dosimetry of [177Lu]Lu-PSMA-617 in patients with metastatic castration-resistant prostate cancer. A total of 48 patients were analyzed, receiving either 6.0 or 7.4 GBq per cycle.
A Phase 2, Open-Label, Randomized Controlled Trial Evaluating Safety and Efficacy of Dose-Intensified Versus Standard Dosing Regimens of [ 177 Lu]Lu-PSMA-597 in mCRPC (OPTIMAL-PSMA).
The OPTIMAL-PSMA study is a Phase 2, open-label, randomized controlled trial evaluating the safety and efficacy of a dose-intensified regimen of [177Lu]Lu-PSMA-597 versus standard dosing in 120 patients with metastatic…
First-in-Human, Open-label, Single-Arm Phase I Study of [211At] meta-Astatobenzylguanidine in Patients with Pheochromocytoma or Paraganglioma.
This first-in-human, open-label, single-arm Phase I study evaluated the safety and pharmacokinetics of 211At-meta-astatobenzylguanidine (211At-MABG) in 10 patients with unresectable or metastatic pheochromocytomas or…
Follow-Up 18F-Fluorodeoxyglucose Positron Emission Tomography in Treated Patients With Giant Cell Arteritis: A Systematic Review and Metaanalysis.
This systematic review and meta-analysis evaluated the use of 18F-fluorodeoxyglucose (FDG) PET to monitor disease activity in patients with large-vessel giant cell arteritis (LV-GCA) who showed clinical improvement…
[18F]RCCB6 PET/CT in Diagnosing Clear-Cell Renal Cell Carcinomas: A Prospective Comparison Study with [18F]FDG PET/CT and Conventional Imaging.
[18F]RCCB6 PET/CT was evaluated in a single-center phase II trial for detecting metastases in clear-cell renal cell carcinoma (ccRCC).
September 202614
First systematic mapping of non-target [68Ga]Ga-DOTANOC uptake across anatomical sites and etiologies.
This systematic review analyzed 76 studies involving 542 patients to map non-target [68Ga]Ga-DOTANOC uptake across various anatomical sites and etiologies.
PD-L1 PET/CT imaging with 18 F-BMS-986,229 and 18 F-BMS-986,192 in patients with advanced-stage non-small cell lung cancer.
This multicenter clinical trial evaluated baseline PD-L1 PET/CT with two tracers in patients with stage IV non-small cell lung cancer (NSCLC), comparing tumor uptake with biopsy PD-L1 immunohistochemistry (IHC) and…
Evaluating the Clinical Utility of TSPO-PET in MS and the Influence of Methodological Heterogeneity: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated TSPO-PET imaging in multiple sclerosis (MS) patients compared to healthy controls.
Cardiac sympathetic nerve activity in the non-culprit lesion predicts poor prognosis in patients with STEMI.
This prospective study assessed whether regional cardiac sympathetic nerve activity (CSNA) adds prognostic information in 122 patients with STEMI.
Unusual pelvic mass in a young adult: prostatic Ewing's sarcoma with distant metastases.
A man in his 20s presented with urinary obstruction, constipation, and leg pain. Imaging revealed a bulky pelvic mass from the prostate, leading to bilateral hydroureteronephrosis.
Colonic metastasis from anaplastic thyroid carcinoma: The value of [ 18 F]FDG PET/CT in an unusual presentation.
A patient with anaplastic thyroid carcinoma containing a papillary component and a BRAF V600E mutation had locoregional invasion and residual disease detected after surgery. The patient received radiotherapy.
Molecular imaging tracers targeting c-MET: a systematic review of preclinical evidence and clinical translation.
This PRISMA-guided systematic review assessed radioactive and fluorescent tracers targeting c-MET in preclinical and clinical studies.
Reversing the Reverse: Nitrate-Enhanced Tc-99m MIBI MPS Unmasking Microvascular Dysfunction in Takayasu Arteritis.
Takayasu Arteritis (TA) is a large vessel vasculitis involving the aorta and its major branches, which could be complicated by significant cardiovascular manifestations.
The "Scintigraphic Flip": A Visual Warning Sign of Impending Hematologic Toxicity.
A 55-year-old man with metastatic castration-resistant prostate cancer developed increased diffuse marrow uptake and reduced salivary-gland and liver activity on imaging after his second cycle of ¹⁷⁷Lu-PSMA therapy.
Clinical utility of DaTscan in clinically uncertain parkinsonian syndromes: a systematic review and meta‑analysis.
This systematic review and meta-analysis assessed how often DaTscan (123I-ioflupane SPECT) was followed by a diagnostic change in patients with clinically uncertain parkinsonian syndromes.
Dosimetric and therapeutic effectiveness of high-dose-rate radionuclide sources in breast cancer brachytherapy: A systematic review.
This systematic review compared dosimetric properties and therapeutic evidence for ¹⁹²Ir, ⁶⁰Co, and ¹⁶⁹Yb in high-dose-rate breast cancer brachytherapy.
Tri-modal PSMA PET/CT-MRI-US fusion biopsy for clinically significant prostate cancer: a prospective paired diagnostic study.
This prospective, single-centre paired diagnostic accuracy study compared tri-modal PSMA PET/CT-MRI-ultrasound fusion biopsy with MRI-ultrasound fusion and systematic biopsy in 308 biopsy-naive men.
Radium-223 decreases PD-L1 expression in bone metastases: A study with [ 89 Zr]Zr-atezolizumab PET and immunohistological correlation.
This prospective, multicenter clinical study examined immune changes during standard-of-care radium-223 treatment in 28 patients with metastatic castration-resistant prostate cancer and predominantly bone metastases.
Brain serotonin transporter remains stable across seasons: A Bayesian and frequentist meta-analysis.
This meta-analysis examined seasonal variations in brain serotonin transporter (SERT) availability in healthy individuals using neuroimaging studies.
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