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557 articles
October 202624
Steroid-associated hypofibrinogenemia: an overlooked risk in graft-versus-host disease management after allogeneic hematopoietic stem cell transplantation.
A 47-year-old woman with acute myeloid leukemia developed late acute gastrointestinal graft-versus-host disease after allogeneic hematopoietic stem cell transplantation and received methylprednisolone at 1 mg/kg/day.
Reduced-dose alternate-day oral iron supplementation in women with iron deficiency: a randomized controlled trial.
This 42-day, randomized, parallel-group active-controlled trial compared two oral iron regimens in 66 women aged 18–50 years with iron deficiency (serum ferritin < 30 ng/mL).
Fatal Rickettsia parkeri Rickettsiosis in Immunocompromised Pediatric Patient, Georgia, USA, 2025.
A 3-year-old boy in Georgia, USA, receiving chemotherapy for B-cell acute lymphoblastic leukemia was hospitalized with febrile neutropenia.
Efficacy and safety of mitapivat in patients with sickle cell disease (RISE UP): a phase 3, double-blind, global, randomised, placebo-controlled trial.
RISE UP was a phase 3, double-blind, global, randomised, placebo-controlled trial conducted at 69 sites in 15 countries. It evaluated twice-daily mitapivat in patients older than 16 years with sickle cell disease…
HHV8-associated multicentric Castleman disease with Kaposi sarcoma in an immunocompetent patient: a case report and review of the literature.
A 57-year-old man presented with five months of generalized lymphadenopathy, weakness, cough, fever, and weight loss. HIV, CMV, EBV, and tuberculosis tests were negative.
Evaluating the effectiveness of the eHealth-faciLitated SMILe-integrated care model on treatment burden, quality of life and graft-versus-host disease after allogeneic stem cell transplantation: results of two European randomized controlled implementation studies.
Two multicentre, hybrid effectiveness-implementation randomised controlled trials at European allogeneic stem cell transplantation (alloSCT) centres evaluated SMILe-ICM, an eHealth-supported, advanced practice nurse-led…
The perceptions of hematopoietic stem cell transplantation decision-making in patients with hematologic malignancies: a qualitative systematic review.
This qualitative systematic review synthesized research on how patients with hematologic malignancies perceive decisions about hematopoietic stem cell transplantation (HSCT).
Bing-Neel syndrome successfully treated with venetoclax and zanubrutinib: A case report and review of the literature.
A 66-year-old woman with Waldenström macroglobulinemia presented with headache and was diagnosed with Bing-Neel syndrome after cerebrospinal fluid examination. She received zanubrutinib with venetoclax.
Effect of Danggui Buxue Medicinal Diet on cancer-related fatigue in anemic colon cancer patients undergoing chemotherapy: A randomized controlled trial (CONSORT-compliant).
This randomized controlled trial evaluated a 21-day Danggui Buxue Medicinal Diet alongside standard care in patients with chemotherapy-induced anemia after colon cancer surgery.
Relapsed Waldenström macroglobulinemia presenting as bilateral parotid gland enlargement with multiple cystic lesions: A case report.
A 79-year-old man with Waldenström macroglobulinemia (WM), previously stable for several years after multiple courses of chemotherapy, developed bilateral parotid enlargement. Imaging showed multiple cystic lesions.
A case of lysozyme-induced nephropathy with improved renal function following treatment for chronic myelomonocytic leukemia.
A 75-year-old man with longstanding diabetes presented with weight loss and progressive anemia and was diagnosed with chronic myelomonocytic leukemia (CMML).
Effectiveness of tocilizumab monotherapy for IgG4-related disease-like features caused by idiopathic multicentric Castleman's disease: a case-based review.
A 68-year-old woman presented with dyspnea associated with a recurrent laryngeal tumor, pulmonary consolidation, mediastinal and axillary lymphadenopathy, sclerosing mesenteritis, and retroperitoneal fibrosis.
Concurrent administration of BCMA and GPRC5D CAR T cells for advanced multiple myeloma.
This phase 1 dose-escalation trial evaluated BCMA-directed CAR T-cell therapy MCARH125 alone or infused concurrently with GPRC5D-directed MCARH109 in patients with relapsed or refractory multiple myeloma.
Anbalcabtagene autoleucel (PD-1 and TIGIT knockdown CD19 CAR T-cell therapy) for relapsed or refractory LBCL: the CRC01-01 trial.
The multicenter phase 1/2 CRC01-01 trial evaluated anbalcabtagene autoleucel, a CD19 CAR T-cell therapy with PD-1 and TIGIT knockdown, in patients with relapsed or refractory large B-cell lymphoma.
Firstline treatment with ruxolitinib versus best available therapy in patients with polycythemia vera: results from the randomized RuxoBEAT trial.
The multicenter randomized RuxoBEAT trial compared first-line ruxolitinib (RUX) with best available therapy (BAT) in patients with polycythemia vera.
The role of allogeneic hematopoietic stem cell transplantation in adults with mature T-cell lymphomas.
This Cochrane systematic review and meta-analysis assessed allogeneic stem cell transplantation (alloSCT) for adults with mature T-cell lymphomas (MTCL), as first-line or salvage treatment.
Ruxolitinib for the treatment of pediatric acute and chronic steroid-refractory graft-versus-host disease: Efficacy, safety, and outcomes.
This single-center retrospective study assessed ruxolitinib in children under 18 years with steroid-refractory graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
Natural History and Therapeutic Response in Ophthalmic Plasminogen Deficiency: Two Cases and Call for Registry-Based Data.
The report describes two patients with type 1 plasminogen deficiency and ligneous conjunctivitis. A 65-year-old woman with untreated disease had recurrent conjunctivitis, ultimately requiring enucleation, and developed…
Teclistamab Induced a Profound Hematologic Response in Light Chain Deposition Disease With Probable Cardiac Involvement.
A 63-year-old man had κ-light chain deposition disease involving the kidneys, with probable cardiac involvement. After an initial response to daratumumab-pomalidomide-dexamethasone, he developed hematologic relapse.
Challenges of Conducting a Feasibility Pilot Randomized Controlled Trial During COVID-19 Restrictions: Rivaroxaban Versus Acetyl Salicylic Acid in Patients with Multiple Myeloma on Lenalidomide-Based Therapy (RithMM).
This multicentre pilot randomised controlled trial assessed whether a full-scale comparison of rivaroxaban and acetylsalicylic acid for thromboprophylaxis was feasible in patients with multiple myeloma receiving…
Exceptional Thyroid Recurrence of Solitary Bone Plasmacytoma Detected by 18 F-FDG PET/CT.
A 70-year-old man previously treated with radiotherapy for solitary bone plasmacytoma of the left hemipelvis underwent 18 F-FDG PET/CT follow-up.
Efficacy and safety of ifupinostat in relapsed or refractory diffuse large B-cell lymphoma: a multicenter, single-arm phase 2 study.
This multicenter, single-arm phase 2 study evaluated intravenous ifupinostat monotherapy in patients with relapsed or refractory diffuse large B-cell lymphoma after at least two prior systemic therapy lines.
Premature treatment cessation in pediatric acute myeloid leukemia due to excessive toxicity: clinical experiences and patient outcomes - a case series.
A Dutch national database review identified seven children with acute myeloid leukemia (AML) whose chemotherapy was stopped early because of excessive toxicity. Severe fungal infection prompted discontinuation in five.
Non-Relapse Mortality With Bispecific Antibodies in Hematologic Malignancies: A Dual Systematic Review and Pharmacovigilance Analysis.
This systematic review and meta-analysis, supplemented by a pharmacovigilance analysis of FAERS, assessed non-relapse mortality (NRM) and other toxicities with bispecific antibodies in relapsed/refractory hematologic…
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