Trending archive
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137 articles
September 20265
Recurrent severe cutaneous reaction to fluoroquinolones and rifampicin in a human immunodeficiency virus-positive patient with disseminated tuberculosis: A rare case report.
A 47-year-old male with HIV and disseminated tuberculosis experienced recurrent maculopapular eruptions with mucosal involvement after exposure to multiple medications, including fluoroquinolones and rifampicin.
Chronic autoimmune urticaria with worsening during the luteal phase suggestive of progesterone hypersensitivity successfully treated with rituximab.
A 30-year-old woman with glucocorticoid-dependent chronic spontaneous urticaria (CSU) presented with cyclical worsening of symptoms during her luteal phase.
Pharmacokinetic and Pharmacodynamic Bio-Similarity of ADL-018 to Innovator Omalizumab: A Randomized Study in Healthy Adults.
This randomized controlled trial evaluated the pharmacokinetic and pharmacodynamic bio-similarity of ADL-018, a biosimilar to omalizumab, in 306 healthy adults.
Suspected menopause nutraceutical-induced eosinophilic ascites: a rare clinical presentation.
A middle-aged woman presented with a 2-month history of ascites and marked peripheral eosinophilia (49%). Analysis of her ascitic fluid revealed 90% eosinophils, with no malignancy detected.
Asthma Exacerbation Risk and School Asthma Readiness.
This randomized controlled trial evaluated school asthma readiness and its association with asthma exacerbations in a cohort of 202 children aged 5 to 13 years, predominantly Black and non-Hispanic.
August 202612
A novel FLNA p.Pro2469Ser variant is associated with impaired T and NK cell function and immune dysregulation.
FLNA encodes filamin A, a ubiquitously expressed actin-binding cytoskeletal protein that cross-links actin filaments and links them to membrane-associated signaling complexes.
Recurrent Sterile Polyserositis Reveals an Underrecognized Autoinflammatory Phenotype in MECP2 Duplication Syndrome.
In a retrospective multicenter review of four patients with MECP2 duplication syndrome, each developed recurrent pleural and/or pericardial effusions with systemic inflammation, including leukocytosis, elevated…
Successful 15-step desensitization protocol for nivolumab and ipilimumab after a skin-test confirmed anaphylaxis to polysorbate 80: case report.
A 53-year-old man with advanced melanoma developed grade III anaphylaxis during his first nivolumab infusion. Allergy testing showed immediate hypersensitivity to polysorbate 80 and a positive test to polysorbate 20…
Long-term outcomes of anti-CD19 CAR T cell therapy in refractory myasthenia gravis: A case series.
Three patients with severe, treatment-resistant myasthenia gravis (MG) were treated with autologous anti-CD19 CAR T cell therapy.
Symptom burden to characterise, predict, and prevent asthma attacks: a patient-level meta-analysis of randomised trials and translational prospective studies.
This patient-level meta-analysis evaluated the prognostic value of symptom burden, measured by the ACQ-5, in predicting severe asthma attacks among 7161 participants from various studies.
Classroom microbiome signatures of pest management associate with reduced asthma symptoms.
This ancillary study of a randomized, placebo-controlled trial examined whether school-based integrated pest management (IPM) altered classroom microbiomes and whether intervention-associated microbial signatures…
Mepolizumab effectiveness for patients with severe, uncontrolled chronic rhinosinusitis with nasal polyps in Italy (MEPOREAL): a real-life, multicentre, phase 4 trial.
MEPOREAL was a real-life, multicentre, ambispective phase 4 study of mepolizumab in patients with severe, uncontrolled chronic rhinosinusitis with nasal polyps at 25 Italian referral clinics.
A multiple ascending dose, phase1b study to evaluate safety, tolerability, pharmacokinetics, and pharmacodynamics of lesigercept, a long-acting IgE Trap -Fc fusion protein, in participants with atopy or allergic diseases.
This phase 1b randomized controlled trial evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of lesigercept in adults with atopy or allergic diseases.
Immunomodulatory effects of palm-derived tocotrienol-rich fraction in healthy volunteers following influenza vaccination: A randomised clinical trial.
This randomized controlled trial evaluated the immunomodulatory effects of palm-derived tocotrienol-rich fraction (TRF) on the immune response to influenza vaccination in 150 healthy adults.
Efficacy and safety of nasal saline irrigation for allergic rhinitis in children and adolescents: A systematic review and meta-analysis with GRADE assessment.
This systematic review and meta-analysis evaluated the efficacy and safety of nasal saline irrigation (NSI) for allergic rhinitis in children and adolescents.
Severe atopic dermatitis and growth failure associated with a STAT5B gene mutation in a 7-month-old infant.
A 7-month-old boy with no significant perinatal history was referred for a skin condition present for 5 months and severe growth retardation, including low weight for height.
Efficacy and safety of allergen immunotherapy in lipid transfer protein food allergy: An updated systematic review.
This updated systematic review assessed sublingual and oral Pru p 3-based immunotherapy for patients with lipid transfer protein (LTP)-mediated food allergy.
July 20267
Biologics and Selected Upper- and Lower-Airway Outcomes in AERD Subgroups: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed biologics versus placebo for selected upper- and lower-airway outcomes in patients with aspirin-exacerbated respiratory disease (AERD) represented in randomized…
Tezepelumab in Chinese Patients With Severe Chronic Rhinosinusitis With Nasal Polyps: A Prespecified Subgroup Analysis of the Phase 3 WAYPOINT Trial.
This prespecified subgroup analysis of the phase 3, randomized WAYPOINT trial assessed tezepelumab in Chinese adults with severe chronic rhinosinusitis with nasal polyps (CRSwNP).
Dupilumab effectiveness and safety in patients with chronic rhinosinusitis with nasal polyps: Two-year results from the Assessing long-teRm Outcomes in dupiluMAb registry.
The phase 4, prospective, global AROMA registry followed adults with chronic rhinosinusitis with nasal polyps (CRSwNP) initiating dupilumab in real-world practice.
Epitope-specific IgE profiles are predictive of desensitization and remission in the IMPACT trial.
The IMPACT trial, a randomized controlled trial, evaluated the predictive value of epitope-specific IgE profiles for desensitization and remission in children undergoing peanut oral immunotherapy (pnOIT).
Dupilumab for patients with allergic fungal rhinosinusitis.
This phase 3 randomized, placebo-controlled trial evaluated dupilumab in patients aged 6 years or older with allergic fungal rhinosinusitis over 52 weeks.
Allergic contact dermatitis after laser-assisted photodynamic therapy with 5-aminolevulinic acid: evidence of cross-sensitization to methyl aminolevulinate.
A 67-year-old male developed severe eczematous dermatitis after laser-assisted photodynamic therapy using 5-aminolevulinic acid for actinic keratoses.
Recreational Allergic Contact Dermatitis to "Epoxy UV" Resins: A New Source of Exposure to Hidden (Meth)acrylates.
Three people developed eczematous eruptions after using products labelled “epoxy UV” resin to make jewellery. Patch testing showed sensitization to (meth)acrylates, but not to the epoxy compounds tested.
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