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557 articles
April 202613
Conjunctival AL amyloidosis as the initial manifestation of multiple myeloma.
A 74-year-old man developed raised yellowish-salmon conjunctival plaques during follow-up after cataract surgery. Incisional biopsy showed subepithelial amyloid deposits, Congo red positive, with immunohistochemistry…
Pneumococcal HUS in infancy masking DGKE-related thrombotic microangiopathy with secondary hemophagocytic lymphohistiocytosis.
A 7-month-old boy presented with pneumonia, anemia, thrombocytopenia, and acute kidney injury. Pneumonia on imaging, elevated CRP, and a positive nasopharyngeal pneumococcal PCR initially supported…
First report of bacteremia caused by CO 2 -dependent methicillin-resistant Staphylococcus epidermidis in a patient with symptomatic multiple myeloma.
A patient with symptomatic multiple myeloma had blood cultures showing Gram-positive cocci. Molecular testing identified S.
Validity, Reliability, and Responsiveness of the EQ-5D in Hematological Cancers: A Systematic Review of Measurement Properties.
This systematic review assessed the validity, test-retest reliability, and responsiveness of the EQ-5D-3L and EQ-5D-5L in adults with hematological cancers.
A Rare Case of Cutaneous Extramedullary Hematopoiesis in Chronic Myeloid Leukemia.
A 34-year-old Hispanic man presented with multiple bilateral lower-extremity skin lesions, right buttock and leg pain, fatigue, and splenomegaly; evaluation identified chronic-phase chronic myeloid leukemia (CML).
Diagnostic performance and heterogeneity of validated flow cytometry scores: a systematic review.
This systematic review examined validation evidence for flow cytometry diagnostic scores, focusing on B-lymphoid disorders (B-LPD) and myelodysplastic syndrome (MDS).
Extranodal Natural Killer/T-Cell Lymphoma Mimicking Chronic Mucormycosis.
A 34-year-old woman presented with progressive, destructive midline facial lesions that raised concern for chronic rhinofacial mucormycosis.
Systematic Review and Meta-analysis on the Prevalence of Common Hemoglobinopathies in India.
This systematic review and meta-analysis estimated the prevalence and distribution of common hemoglobinopathies across demographic groups in India.
Preemptive hematopoietic stem cell transplantation in RUNX1 familial platelet disorder: a shared decision-making framework.
An individual with RUNX1 familial platelet disorder (RUNX1-FPD) and a family history of hematologic malignancy underwent allogeneic hematopoietic stem cell transplantation (HSCT) before overt malignancy developed.
Treatment of TP53 -mutated myelodysplastic syndrome and acute myeloid leukemia with low-intensity metronomic decitabine and venetoclax.
This phase II clinical trial analysis examined low-intensity, once-weekly decitabine plus venetoclax in 40 patients with TP53-mutated myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML); 26 were treated in a…
The association between serum trace elements and iron deficiency anemia in children and adolescents: a systematic review and meta-analysis.
This systematic review and meta-analysis examined serum iron, zinc, copper, and magnesium in children and adolescents with iron deficiency anemia (IDA), using observational studies identified through January 2025.
Atypical immune dysfunction in G6PD deficiency: a case of mosaic neutrophil oxidative burst.
A 50-year-old woman with recurrent infections, including multiple pneumonias, and a history of splenectomy was found to carry G6PD c.202G > A and c.376A > G variants.
B -Cell Maturation Antigen-CD19 Dual-Targeted Chimeric Antigen Receptor- T -Cell Therapy for Relapsed or Refractory AL Amyloidosis.
This single-centre exploratory phase I clinical trial assessed BCMA-CD19 dual-targeted CAR T-cell therapy in six patients with relapsed or refractory AL amyloidosis after at least two prior treatment lines; all had…
March 202611
Pulmonary Leukocytoclastic Vasculitis Associated with Myelodysplastic Syndrome.
A man in his 50s with myelodysplastic syndrome presented with fever, pulmonary infiltrates, and persistent inflammation despite antibiotic treatment.
Fatal Edwardsiella tarda Sepsis in a Patient with End-stage Multiple Myeloma: A Case of Suspected Zoonotic Transmission.
A 74-year-old man with refractory end-stage multiple myeloma and profound treatment-related immunodeficiency developed septic shock after acquiring tropical fish.
Case report: persistent anemia after eculizumab in paroxysmal nocturnal hemoglobinuria: non-dominantly active intravascular hemolysis.
A patient with paroxysmal nocturnal hemoglobinuria initially responded to eculizumab but developed recurrent hemoglobin decline and transfusion dependence after 24 weeks.
Clinical clues to recognizing hereditary dehydrated stomatocytosis (DHSt) in children.
The abstract describes a series of 20 pediatric and adult patients with dehydrated hereditary stomatocytosis (DHSt), an autosomal dominant group of hemolytic disorders.
VEXAS Syndrome with an Improvement of Chest Shadows without Immunosuppressive Therapy.
An 86-year-old man presented with elevated C-reactive protein, bicytopenia, and bilateral chest shadows. Bronchoalveolar lavage showed an increased lymphocyte count.
Decrease in PNH-type Blood Cells after the Cessation of Thrombopoietin Receptor Agonist in a Case of AA-PNH Syndrome.
A 64-year-old man with severe aplastic anemia had a partial response to immunosuppressive therapy, followed by sustained cytopenia recovery with a thrombopoietin receptor agonist (TPO-RA).
Paraprotein interference in bilirubin assays: A case of multiple myeloma highlighting the reliability of dry chemistry.
A 60-year-old man with nonspecific symptoms had no jaundice and normal-appearing imaging. Wet chemistry testing reported total bilirubin of 0.39 mg/dL and an impossible direct bilirubin of -7.67 mg/dL.
The correlation between cardiac T2*MRI and B-Type natriuretic peptides in patients with transfusion-dependent anemias and systemic iron overload: a systematic review and meta-analysis.
This systematic review and meta-analysis examined whether B-type natriuretic peptide (BNP) and NT-proBNP levels are associated with cardiac T2* MRI measures of myocardial iron in patients with transfusion-dependent…
Risk of adverse events in elotuzumab-treated patients with multiple myeloma: a systematic review and meta-analysis.
This systematic review and meta-analysis pooled adverse-event data from six randomized controlled trials involving 1,736 patients with multiple myeloma treated with elotuzumab-containing regimens or control therapies.
Prophylactic Recombinant Human Thrombopoietin Prevents Cancer Therapy-Induced Thrombocytopenia During Concurrent Chemoradiation Therapy in Limited-Stage Small Cell Lung Cancer: A Prospective, Multicenter, Phase II Clinical Trial.
This prospective, multicenter, phase II trial assessed prophylactic recombinant human thrombopoietin (rhTPO) during concurrent chemoradiation in patients with limited-stage small cell lung cancer.
Severe Aplastic Anemia Concurrent with Lymphoplasmacytic Lymphoma/Waldenström's Macroglobulinemia.
A 79-year-old woman presented with progressive dyspnea. Bone marrow biopsy showed hypoplastic marrow containing abnormal lymphoid cells, and genetic analysis identified a MYD88 p.V204F mutation supporting…
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