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845 articles
November 202624
Erdheim-Chester disease: a diagnostic dilemma - a report of four cases.
Four adults aged 27–40 years presented with neurological Erdheim-Chester disease (ECD), with manifestations including cerebellar ataxia, dysarthria, tremor, visual deterioration, and headache.
STAT6-positive solitary fibrous tumour of the lacrimal gland with floret-type giant cells: a rare case report.
A 52-year-old man presented with five months of enlarging left lacrimal swelling, proptosis, and mildly reduced visual acuity. CT showed a well-defined 9 × 12 mm orbital lesion without bone erosion or local invasion.
Coexistence of ARNT::ALK and TPM3::ALK doublegene fusion in an ALK-rearranged renal cell carcinoma with osseous metaplasia.
An adult patient had an ALK-rearranged renal cell carcinoma. The tumor showed varied growth patterns in a mucinous background, with a small peripheral focus of osseous metaplasia.
Successful ABO-incompatible renal transplantation of blood group A1 donor into A2 recipient with anti-A1 isoagglutinins: case report and review of literature.
A 73-year-old woman with end-stage kidney disease due to AL amyloidosis was evaluated for kidney transplantation. An ABO typing discrepancy led to serologic testing and genotyping, which confirmed an A2 recipient with…
Longitudinal remodeling of the tumor-immune microenvironment during regorafenib, nivolumab, and chemotherapy in advanced gastric cancer.
This phase 1b/2 clinical trial evaluated first-line regorafenib, nivolumab, and chemotherapy in 30 patients with mismatch repair-proficient advanced gastric cancer, alongside longitudinal analysis of tumor biopsies.
Late-onset Niemann-Pick C disease in a patient with spastic ataxia and hyperkinetic involuntary movements: a case report.
A woman with late-onset Niemann-Pick disease type C1 presented from age 50 with progressive postural instability, falls, spastic ataxia, and prominent upper-limb hyperkinetic movements.
Histologic Evaluation of Bone Regeneration Using the Subperiosteal Peri-implant Augmented Layer (SPAL) Technique Combined with Deproteinized Bovine Bone Mineral: A Case Report.
Six patients with peri-implant bone dehiscence underwent augmentation using the subperiosteal peri-implant augmented layer (SPAL) technique with particulate deproteinized bovine bone mineral.
Pseudo-Metabolic Alkalosis: A Hidden Laboratory Pitfall With Elevated LDH.
A 33-year-old man presented with progressive exertional dyspnea, syncope, and paresthesia. Testing showed pancytopenia, macrocytosis, LDH >3600 U/L, low haptoglobin, and vitamin B₁₂ <68 pg/mL, consistent with pernicious…
Multidrug-resistant (MDR) Salmonella Typhi spondylodiscitis with vertebral collapse: a case report.
A 49-year-old woman with diabetes and hypertension developed persistent back pain after enteric fever. Imaging showed spondylodiscitis with vertebral collapse, raising concern for tuberculosis or metastatic disease.
Spatial Acid-Associated Niches Inform Irinotecan-Based DEB-TACE in Colorectal Liver Metastases: A Multicentre Randomized Trial.
This multicentre randomised trial combined transcriptomic and spatial analyses of colorectal liver metastases (CRLM), laboratory testing of irinotecan-eluting microspheres, and clinical evaluation in 35 patients with…
A Case of Facial Alternaria alternata Infection in an Immunocompetent Male with Albinism.
A 26-year-old immunocompetent man with albinism who worked in breeding presented with a two-month history of itchy facial rashes.
Short communication: Urinary schistosomiasis mimicking a bladder tumour in a Somali student diagnosed in Türkiye.
A 20-year-old Somali student living in Türkiye presented with painless visible haematuria and lower urinary tract symptoms. He had a history of freshwater exposure in Somalia.
Duodenal Adenocarcinoma Recurrence Limited to the Choledochojejunostomy After Pancreaticoduodenectomy: A Case Suggesting Intraluminal Implantation With a Distinct Mucin Phenotypic Shift.
A 59-year-old man developed recurrence at the choledochojejunostomy 27 months after pancreaticoduodenectomy for duodenal adenocarcinoma, despite five surgically created raw surfaces.
Angiosarcoma in the Setting of Vascular Procedures: A Systematic Review and Our Experiences.
Angiosarcoma is a rare, aggressive endothelial malignancy with a poor prognosis; diagnosis is often delayed by vague symptoms, nonspecific imaging, and challenging histopathology.
TIM3 Blockade with Hypomethylating Therapy Restores NK Cell and Cytotoxic CD4+ T-cell Activity in Patients with AML or MDS.
This phase Ib clinical trial examined immune changes in patients with AML or MDS treated with anti-TIM3 sabatolimab plus decitabine.
Acquired haemophilia B in Kyasanur Forest disease: a case series of isolated prolonged activated partial thromboplastin time.
Nine patients with confirmed acute Kyasanur Forest disease had prolonged activated partial thromboplastin time (APTT) with normal prothrombin time.
Shotgun metagenomic characterization of human adenovirus F40 and a non-cpe Clostridium perfringens strain in pediatric prolonged diarrhea: a genome-resolved case study.
A child with prolonged diarrhea had adenovirus identified as the sole pathogen by routine testing. Shotgun metagenomic sequencing of stool confirmed human adenovirus F40 (HAdV-F40), phylogenetically distinct from…
Adjuvant mFOLFOXIRI after curative-intent resection of oligometastatic colorectal cancer: phase II FANTASTIC trial.
The multicentre, non-randomized phase II FANTASTIC trial evaluated adjuvant modified FOLFOXIRI after complete metastasectomy for oligometastatic colorectal cancer and assessed circulating tumour DNA (ctDNA).
Transbronchial Cryobiopsy for the Diagnosis of Peripheral Pulmonary Lesions: A Prospective Randomized Controlled Study.
This prospective, single-center randomized controlled study compared radial endobronchial ultrasound with guide-sheath-assisted transbronchial cryobiopsy (TBCB) using a 1.1-mm ultrathin probe with conventional forceps…
Submucosal Tunnel Endoscopic Resection of a Gastric Schwannoma Mimicking a Submucosal Tumor.
A 73-year-old woman with recurrent abdominal distension was found on esophagogastroduodenoscopy to have an 8.2 mm submucosal lesion in the gastric body.
Pediatric suprasellar primary CNS lymphoma with cavernous sinus invasion and ischemic stroke: a case report and systematic review.
A 12-year-old immunocompetent girl presented with high fever, severe headache, and diplopia, followed by rapid neurological deterioration.
Multidisciplinary Single Stage Surgical Management of Advanced Breast Carcinoma With Concomitant Left Atrial Myxoma.
A 58-year-old woman with locally advanced invasive mucinous breast carcinoma had a progressive fungating mass despite neoadjuvant chemotherapy and radiotherapy.
Pulmonary-Cardiac Involvement in a Patient with IgA Vasculitis.
A 41-year-old woman with biopsy-proven IgA nephropathy presented with progressive dyspnea, hemoptysis, and a painful purpuric rash.
Anterior Chest Wall Tuberculosis Masquerading as a Chronic Parasternal Sinus in an Apparently Immunocompetent Adult: A Diagnostic Challenge in a Resource-Limited Setting.
A previously healthy 22-year-old man presented with an enlarging parasternal-xiphoid swelling and intermittent seropurulent drainage, without respiratory or constitutional symptoms.
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