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1357 articles
November 202624
Anatomy-specific Performance of CTA-based AI for Anterior Circulation Occlusion: Systematic Review and Meta-analysis.
This prospectively registered systematic review and diagnostic meta-analysis assessed CTA-based artificial intelligence for detecting anterior-circulation occlusions, using 31 reports involving 15 708 patients.
Interventions to Increase Organ Donation: A Systematic Review.
This systematic review synthesized United States-based studies of interventions intended to increase organ donation among adults.
Severe Infection Outcomes With SGLT2 Versus DPP-4 Inhibitors in Type 2 Diabetes: A Systematic Review and Active-Comparator Meta-Analysis of Real-World Cohorts.
This systematic review and active-comparator meta-analysis examined real-world severe infection outcomes among people with type 2 diabetes treated with SGLT2 inhibitors versus DPP-4 inhibitors.
Effectiveness of Traditional Chinese Fitness Methods on Depressive Symptoms and Glycaemic Control in Patients With Type 2 Diabetes and Comorbid Depression: A Systematic Review and Meta-Analysis of Taijiquan and Baduanjin.
This systematic review and meta-analysis assessed randomised controlled trials of Taijiquan and Baduanjin in people with type 2 diabetes and comorbid depression. Eight trials, all conducted in China, were included.
Paxalisib with Trastuzumab for HER2-Positive Metastatic Breast Cancer with Active Brain Metastases: A Phase II Trial with Integrated Plasma and CSF ctDNA Analyses.
This phase II trial evaluated brain-penetrant paxalisib plus trastuzumab in patients with active or progressive HER2-positive breast cancer brain metastases, including heavily pretreated patients; leptomeningeal disease…
Systematic Review of Smart Home Assistive Technology Devices for Supporting People With Dementia Living in Their Homes.
This systematic review and meta-analysis assessed smart home and wearable assistive technologies for people with dementia living at home or in supported accommodation.
Immune Checkpoint Inhibitor Rechallenge After Immune-Related Adverse Events: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis pooled observational cohort evidence on restarting immune checkpoint inhibitors (ICIs) after treatment interruption for an immune-related adverse event (irAE).
Efficacy of Technology-Augmented Behavioral Counseling for Risky Firearm Behaviors: A Randomized Clinical Trial.
This two-arm randomized clinical trial tested IntERact, a 30-day program combining telehealth behavioral counseling and tailored smartphone content, against enhanced usual care among 373 emergency department patients…
Serum Insulin-Like Growth Factor-1 (IGF-1) in Parkinson's Disease: A Systematic Review and Meta-Analysis.
This systematic review and random-effects meta-analysis examined observational studies comparing serum IGF-1 in people with Parkinson’s disease (PD) and healthy controls, and studies of associations with PD symptoms.
Effects of Exercise Type and Duration on Pain, Function, and Quality of Life in Patients With Knee Osteoarthritis: A Systematic Review With Bayesian Network Meta-Analysis.
This systematic review with Bayesian network meta-analysis compared aerobic, resistance, and combined exercise for pain, function, and quality of life in people with knee osteoarthritis.
The two-shot protocol. A randomized controlled trial of a novel two-injection ovarian stimulation strategy.
This phase III, single-centre randomised non-inferiority trial compared two sequential corifollitropin alfa (CFA) injections with conventional CFA followed by recombinant FSH in women undergoing elective fertility…
Therapeutic Approaches and Clinical Outcomes of Myeloid/Lymphoid Neoplasms With Eosinophilia Harboring FLT3 Rearrangements: A Systematic Review of 39 Cases.
This systematic review examined treatment approaches and outcomes in 39 reported cases of myeloid/lymphoid neoplasms with eosinophilia harboring FLT3 rearrangements, a rare malignancy without standardized treatment…
First-in-Human Regulatory T Cell-Derived Exosomes Plus Ranibizumab for Refractory nAMD.
This single-centre, prospective, open-label phase 1a dose-escalation trial evaluated the safety and maximum tolerated dose of intravitreal autologous regulatory T cell-derived exosomes (TregExo) coformulated with…
Can Clinicians Predict Which Patients Respond Best to a Specific Treatment? A Systematic Review of Low Back Pain Moderators in Primary Care.
This systematic review synthesized randomized trials and secondary analyses examining whether patient characteristics modify responses to primary care interventions for nonspecific low back pain.
Exercise and Nutritional Interventions for Muscle Strength, Physical Performance, and Body Composition Among Older Adults With Sarcopenia or Pre-Sarcopenia: A Network Meta-Analysis.
This network meta-analysis compared exercise, nutritional, and combined interventions with control strategies in older adults with sarcopenia or pre-sarcopenia.
Digital reminder systems for improving adherence to anti-rabies vaccination among animal bite victims: A systematic review.
This systematic review assessed whether digital reminders improve adherence to and completion of anti-rabies vaccination among animal-bite patients.
Biomarker Modulation by Aspirin and Metformin for Colorectal Cancer Prevention: Results from the ASAMET Randomized Phase II Trial.
The multicenter, double-blind, 2 × 2 factorial phase II ASAMET randomized trial evaluated aspirin, metformin, and their combination for 12 months in patients with resected stage I to III colorectal cancer.
LEgal Guidance for Cancer Patients and CAREgivers (LEGACY CARE): A Pilot Clinical Trial.
This single-arm pilot clinical trial evaluated the feasibility and acceptability of proactive legal care for patient-caregiver dyads affected by advanced-stage colorectal cancer.
Elevated Lipoprotein(a) Predicts Recurrent Myocardial Infarction in Diabetic Patients Following Acute Coronary Syndromes.
This PRISMA-guided systematic review and meta-analysis assessed whether elevated lipoprotein(a) predicts recurrent events in patients with diabetes after acute coronary syndrome or percutaneous coronary intervention.
Interventions to Support Parents Whose Babies Cry Excessively: Systematic Review.
This systematic review and meta-analysis assessed comparative studies of interventions supporting parents of babies aged ≤1 year with excessive crying.
Clinical outcomes and euploidy rates of embryos derived from zygotes with nonpronuclear (0PN) and monopronuclear (1PN) in IVF or ICSI cycles: a systematic review and meta-analysis.
This systematic review and meta-analysis compared euploidy and clinical outcomes for embryos derived from 0PN or 1PN zygotes with those from normally fertilized 2PN zygotes in IVF/ICSI cycles.
Compositional, Spatial and Functional Changes Occur Within Bacteria Associated With Precancerous Colonic Lesions: A Systematic Review.
This systematic review examined human studies comparing gut microbiota in people with colorectal polyps and healthy controls defined by normal colonoscopy.
Effects of Integrated Multicomponent Care on Older Adults With Frailty or Pre-Frailty: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed integrated multicomponent care (IMC) for older adults with frailty or pre-frailty, including evidence from 20 randomised and quasi-experimental studies.
Evaluating the accuracy of brief cognitive assessments for the early detection of cognitive impairment in adults across primary and specialty care settings: A systematic review and meta-analysis.
This systematic review and meta-analysis assessed brief, freely available cognitive tests for detecting cognitive impairment, including mild cognitive impairment and dementia, in adults aged 55 years and older in…
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