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557 articles
August 202624
A randomized pilot trial comparing anti-thymocyte globulin with anti-thymocyte globulin plus post transplant cyclophosphamide for prophylaxis against acute and chronic graft versus host disease in matched donor hematopoietic cell transplants - a study from the Cell Therapy Transplant Canada/ Australasian Leukemia Lymphoma Group Consortium.
This multicentre randomized pilot trial compared anti-thymocyte globulin (ATG) alone with ATG plus post-transplant cyclophosphamide (PTCy) for graft-versus-host disease prophylaxis in 79 patients with AML or MDS…
Second umbilical cord blood transplantation for relapsed adverse-risk acute myeloid leukemia patient with near-homozygous HLA haplotypes.
A patient with adverse-risk acute myeloid leukemia (AML) and near-homozygous HLA haplotypes underwent double units unrelated umbilical cord blood transplantation (dUCBT) twice.
Prevalence and risk factors of red blood cell alloimmunization among sickle cell disease patients in resource-limited countries: A systematic review and meta-analysis.
This systematic review and meta-analysis examined the prevalence and risk factors of red blood cell alloimmunization among sickle cell disease patients in low- and lower-middle-income countries.
Emergent Reversal of Intracranial Hemorrhage Using 4-Factor Prothrombin Complex Concentrate in a Pediatric Patient.
An 11-year-old male with sinusitis complicated by multifocal intracranial abscesses and a superior sagittal sinus thrombus was treated with rivaroxaban.
Early red blood cell transfusion strategy in septic shock among patients with cancer: the TRANSPORT randomized controlled trial.
The TRANSPORT trial investigated red blood cell transfusion strategies in 187 cancer patients with septic shock. Patients were assigned to either a liberal or restrictive transfusion strategy.
Dulaglutide vs insulin in adolescents with thalassaemia-induced diabetes: effect on metabolism and atherogenesis (DIADEMA).
The DIADEMA trial compared dulaglutide to insulin in adolescents (10-18 years) with thalassaemia-induced diabetes. After 24 weeks, dulaglutide significantly reduced glycaemic variability (CV decreased from 39.45% to…
Voriconazole versus itraconazole for antifungal prophylaxis in patients with graft-versus-host disease: A prospective randomized trial.
This randomized phase II selection trial compared 60 days of voriconazole (VRCZ) with itraconazole (ITCZ) prophylaxis in allogeneic HCT recipients with grade II–IV acute GVHD or chronic GVHD requiring systemic…
Autosomal dominant thrombocytopenia caused by a heterozygous CYCS variant: a new family and literature review.
Four affected members of a Chinese family across three generations had isolated mild-to-moderate thrombocytopenia, with platelet counts of 54 to 83 × 10⁹/L and normal platelet size and morphology.
Multimodal management of refractory gastrointestinal bleeding in myeloma-associated acquired von Willebrand syndrome: a role for emicizumab prophylaxis.
A 72-year-old woman with IgG κ multiple myeloma, acquired von Willebrand syndrome, and gastrointestinal angiodysplasia had recurrent life-threatening bleeding despite factor concentrates, intravenous immunoglobulin…
Intravascular Large B-Cell Lymphoma After Kidney Transplantation: A Rare Form of Post-Transplant Lymphoproliferative Disorder.
A Japanese man in his 60s developed intravascular large B-cell lymphoma (IVLBCL) 4.5 years after kidney transplantation, presenting with general fatigue and loss of appetite.
Concomitant lipid-lowering and anticoagulation therapy for recurrent venous thromboembolism prevention: A Bayesian meta-analysis.
This Bayesian meta-analysis evaluated the efficacy and safety of combined lipid-lowering therapy (LLT) and anticoagulation (AC) for preventing recurrent venous thromboembolism (rVTE) in 28 studies, including 11…
Association between the interleukin 17F rs763780 polymorphism and immune thrombocytopenia risk: A systematic review and meta-analysis.
This meta-analysis examined the association between the interleukin 17F rs763780 polymorphism and immune thrombocytopenia (ITP) risk, analyzing data from eight case-control studies with 805 ITP cases and 841 controls.
Disseminated Ganciclovir-Resistant Cytomegalovirus in a Nontransplant Pediatric ALL Patient: A Case Report.
An 8-year-old patient with T-ALL on maintenance chemotherapy developed significant CMV viremia without initial end-organ disease, which progressed to ganciclovir-resistant CMV infection.
Metabolic mimic of inherited bone marrow failure: LMBRD1 (cblF) deficiency in an infant.
An eight-month-old boy presented with macrocytic anemia, reticulocytopenia, neutropenia, infections, failure to thrive, and developmental delay.
Functional Clopidogrel Resistance and CYP2C19 Genetic Determinants After Lower Limb Endovascular Intervention: A Systematic Review and Meta-analysis of Clinically Relevant Outcomes.
This systematic review and meta-analysis examined whether functional clopidogrel resistance, measured as high on-treatment platelet reactivity (HTPR), and CYP2C19 genetic determinants were associated with outcomes after…
Diagnostic Usefulness of Cell Block Samples in Fluid Overload-Associated Large B-Cell Lymphoma.
An 81-year-old woman presented with pericardial and pleural effusions and was diagnosed with stage IVA fluid overload-associated large B-cell lymphoma (FO-LBCL), despite having no underlying condition that could explain…
Analytical interference by IgM paraprotein causing platform-dependent electrolyte discrepancies: a case-based laboratory investigation.
An 85-year-old man presented with low back pain, and laboratory tests revealed significant discrepancies in serum electrolyte and calcium measurements between two platforms.
A Rare BCR::SPECC1L::ABL1 Fusion in a Pediatric Chronic Myeloid Leukemia Patient.
An 8-year-old girl diagnosed with chronic myeloid leukemia (CML) presented with a typical Philadelphia chromosome and BCR::ABL1 fusion identified through karyotyping and FISH.
The Role of Physical Therapy Across the Transplant Trajectory in Allogeneic Hematopoietic Stem Cell Transplantation, A Systematic Review and Clinical Framework.
This systematic review assessed randomized trials of rehabilitation and exercise in adults undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT), across pre-, peri- and post-transplant phases.
Secondary Hemophagocytic Lymphohistiocytosis Triggered by Mixed Plasmodium spp. and SARS-CoV-2 Coinfection.
A patient with mixed Plasmodium vivax and P. falciparum malaria acquired in Mato Grosso, Brazil, and concomitant SARS-CoV-2 infection presented in nonendemic Macaé with high fever and pancytopenia.
Efficacy and safety of the BEBM (bendamustine, etoposide, busulfan, and melphalan) conditioning regimen for autologous stem-cell transplantation in non-Hodgkin lymphoma.
This phase I, 3 + 3 dose-escalation study assessed adding melphalan to bendamustine, etoposide, and busulfan conditioning for autologous stem-cell transplantation in 12 patients with high-risk or relapsed/refractory…
Secretory Phospholipase A 2 in Patients With Sickle Cell Disease Hospitalized for Vaso-Occlusive Pain Episodes.
This randomized controlled trial evaluated plasma levels of secretory phospholipase A 2 (sPLA 2) in 105 pediatric patients with sickle cell disease hospitalized for vaso-occlusive pain episodes.
Dynamic nature of maternal multiple RBC alloantibodies after vaccination: Case report and immunological mechanisms review.
A 35-year-old pregnant woman presented with multiple red blood cell alloantibodies, including anti-D, anti-C, anti-Fya, and anti-M, detected early in her pregnancy.
Pegtarazimod limits acute graft-versus-host disease mortality and severity in mice and is tolerated in patients.
This phase II clinical trial evaluated the efficacy and tolerability of pegtarazimod in patients with corticosteroid-refractory acute graft-versus-host disease (aGVHD).
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