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557 articles
September 202624
Indwelling pleural catheter enabling safe air travel in malignant pleural effusion with pneumothorax ex vacuo.
A man with pleural mesothelioma developed a large left hydropneumothorax after drainage of malignant pleural effusion. An indwelling pleural catheter was placed, allowing for management of symptoms and the risk of air…
Prevalence and risk factors of recurrent respiratory tract infections in preschool children: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed recurrent respiratory tract infection (RRTI) prevalence and associated risk factors in preschool children. Ten studies including 15,271 children were analyzed.
Endobronchial tuberculosis revealing extensive multiorgan dissemination in a severely malnourished immunocompetent adult.
A woman in her mid-30s presented with a 3-month history of dry cough, significant weight loss, and anorexia. She was diagnosed with pulmonary tuberculosis confirmed by bronchoalveolar lavage and endobronchial biopsy…
Endobronchial epithelioid leiomyoma (leiomyoblastoma) causing complete right-lung atelectasis: A case report.
A 45-year-old woman presented with progressive exertional dyspnea and a persistent dry cough, leading to the discovery of complete right-lung atelectasis.
Heparin-free veno-venous extracorporeal membrane oxygenation as a bridge therapy for airway interventions in malignant central airway obstruction: Case series and literature review.
Three patients with malignant central airway obstruction (MCAO) presented with severe respiratory failure due to bronchial obstruction from tumors.
Robotic-assisted transbronchial biopsy versus computed tomography-guided transthoracic needle biopsy for peripheral pulmonary lesions: a systematic review and meta-analysis of direct comparative studies.
This systematic review and meta-analysis compared robotic-assisted bronchoscopy (RAB) and computed tomography-guided transthoracic biopsy (CTTB) for peripheral pulmonary lesions in adults.
Pulmonary nocardiosis following pembrolizumab use: case report and literature review of nocardiosis associated with immune checkpoint inhibitors.
A woman in her 80s with biliary tract cancer previously treated with pembrolizumab was taking low-dose corticosteroids for immune-related nephritis and hepatitis.
Dupilumab efficacy and safety in patients with allergic bronchopulmonary aspergillosis.
This double-blind phase 2 randomised trial evaluated dupilumab versus placebo in patients aged 12 years or older with asthma and allergic bronchopulmonary aspergillosis (ABPA).
Extracorporeal CO 2 elimination for acute exacerbation of severe COPD requiring invasive mechanical ventilation: a randomized controlled trial (the X-COPD trial).
The X-COPD trial evaluated the impact of extracorporeal CO2 removal (ECCO2R) on clinical outcomes in adults with severe acute exacerbation of COPD requiring invasive mechanical ventilation.
Air Pollution and Heat Impacts on Respiratory Morbidity and Mortality Outcomes in Africa: A Systematic Review Towards a Meta-analysis.
This systematic review and meta-analysis examined the relationship between air pollution and respiratory morbidity in Africa, analyzing data from thirteen studies across ten countries.
When Grief Strains the Heart: A Case of Reverse Takotsubo Cardiomyopathy Triggered by Mourning and Respiratory Failure.
A 69-year-old woman with a history of coronary artery disease and COPD presented with severe respiratory distress and unresponsiveness, requiring intubation.
Daraxonrasib for Previously Treated RAS -Mutant Non-Small-Cell Lung Cancer.
This phase 1-2 multicenter trial evaluated the safety and efficacy of daraxonrasib in 136 patients with previously treated RAS-mutant non-small-cell lung cancer (NSCLC).
The clinical benefit of prostacyclin treatment in mechanically ventilated patients with SARS-CoV-2 infection is not attributed to anti-inflammatory effects.
This randomized controlled trial investigated the effects of iloprost on inflammatory and cytokine responses in 80 mechanically ventilated patients with SARS-CoV-2 infection and endotheliopathy.
Phenome- and laboratory-wide meta-analyses of sickle cell trait reveal multi-system disease associations.
This meta-analysis examined the health outcomes associated with sickle cell trait (SCT) in 4,813 individuals of African genetic ancestry.
A systematic review and network meta-analysis of first-line EGFR-TKI-based combination strategies for EGFR-mutant non-small cell lung cancer with brain metastases.
This systematic review and network meta-analysis evaluated the efficacy and safety of first-line EGFR-TKI-based combination strategies in patients with EGFR-mutant non-small cell lung cancer and brain metastases.
Co-Occurring EGFR L858R Mutation and HER2 Amplification in NSCLC Identified by Stepwise Molecular Profiling.
A 54-year-old non-smoking woman with Stage IIIA lung adenocarcinoma initially tested negative for EGFR mutations. After disease progression and severe chemotherapy toxicity, stepwise molecular profiling revealed HER2…
Swab Testing to Optimize Pneumonia Treatment With Empiric Vancomycin: A Randomized Controlled Trial.
This randomized controlled trial evaluated the impact of MRSA PCR nasal swab testing on vancomycin use in 277 adult ICU patients with suspected community-acquired pneumonia.
Noninvasive Respiratory Support Before Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome: A Meta-Analysis.
This meta-analysis examined whether the duration of respiratory support before ECMO differed between survivors and non-survivors with severe ARDS. Ten observational studies included 718 patients.
Perspective of informal carers on a home-based physical activity programme (iLiFE) for individuals with interstitial lung disease.
This qualitative study, nested within the iLiFE randomised trial, explored informal carers’ perspectives on a home-based physical activity programme for people with interstitial lung disease (ILD).
A Web-Based, Pedometer-Mediated Intervention Increases Amount and Intensity of Physical Activity in COPD: A Randomized Controlled Trial.
This randomized controlled trial evaluated a web-based, pedometer-mediated intervention aimed at increasing physical activity (PA) in individuals with COPD who had not previously participated in pulmonary…
CFTR Modulator Therapy and Aerobic Fitness Changes in Aerobic Fitness Following Initiation of CFTR Modulator Therapy: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the impact of CFTR modulator therapy on aerobic fitness in individuals with cystic fibrosis (n=578).
Awake emergency laparotomy under combined spinal epidural anaesthesia in a high-risk patient with severe pulmonary disease and neuromuscular blocking agent anaphylaxis.
A frail elderly patient with severe chronic obstructive pulmonary disease and anaphylaxis to multiple neuromuscular blocking agents underwent an awake emergency laparotomy using combined spinal-epidural anaesthesia.
Pulmonary arteriovenous malformation (PAVM) with hereditary haemorrhagic telangiectasia (HHT): a rare cause of paradoxical embolic stroke.
A woman in her 40s presented with right-sided hemiparesis, and MRI revealed a left thalamic infarction. Further investigation identified pulmonary arteriovenous malformation (PAVM) associated with hereditary…
Plateau Pressure Exceeding Peak Inspiratory Pressure During Pressure Mode Ventilation With Active Inspiratory Effort.
In patients receiving pressure modes of mechanical ventilation, plateau pressure can be higher than peak inspiratory pressure when the patient has a strong drive to breathe.
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