Trending archive
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495 articles
September 20261
August 202623
Ocular gene therapy targeting retinal angiogenesis and vascular leakage: translational and clinical evidence from a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated ocular gene therapy's effects on retinal angiogenesis and vascular leakage in various studies.
Bilateral granulomatous uveitis mimicking tuberculosis: an atypical ocular presentation of biopsy-proven disseminated histoplasmosis.
A middle-aged immunocompetent male farmer presented with acute bilateral visual loss, redness, and floaters. Examination revealed bilateral granulomatous anterior uveitis with dense vitritis and significant anterior…
Tapioca iris melanoma masquerading as unilateral glaucoma.
A woman in her mid-70s presented with uncontrolled intraocular pressure in her right eye, unresponsive to multiple surgical interventions and topical therapy, while her left eye remained normal.
IgG4-related disease involving facial, infraorbital, auriculotemporal and optic nerves: multinervous cranial involvement in an adult patient.
A man in his mid-40s presented with rapidly progressive orbital symptoms initially diagnosed as orbital cellulitis. Despite treatment, his condition deteriorated, leading to multiple cranial nerve involvement.
Heavy eye syndrome in a paediatric patient: an unusual presentation of highly myopic restrictive strabismus.
A teenage girl presented with progressive myopia and large-angle esotropia, diagnosed with heavy eye syndrome, typically seen in adults.
Voretigene Neparvovec (Luxturna) for Biallelic RPE65-Associated Retinal Dystrophy: Systematic Review.
This systematic review synthesized randomized and observational studies of voretigene neparvovec in people with biallelic RPE65-associated inherited retinal disorders.
Integrated 18 F-NOTA-FAPI-04 PET/MRI for quantitative assessment of disease activity in thyroid-associated ophthalmopathy.
This prospective clinical study evaluated integrated 18F-NOTA-FAPI-04 PET/MRI for distinguishing active from inactive thyroid-associated ophthalmopathy (TAO) in 33 participants, using the Clinical Activity Score (CAS)…
Early Versus Delayed Pegcetacoplan Treatment for Geographic Atrophy Secondary to Age-Related Macular Degeneration in OAKS, DERBY, and GALE.
This analysis compared early with delayed pegcetacoplan treatment for geographic atrophy secondary to age-related macular degeneration, using data from the phase 3 OAKS and DERBY trials and their open-label extension…
Unique retinal phenotype may support pathogenicity of FSCN2 in inherited retinal degenerations: a case report and review of the literature.
A 67-year-old man presented with blurred vision for 20 years, with visual acuities of 20/150 in both eyes. Examination revealed a ceco-central area of pigmentary changes and severe photoreceptor outer nuclear layer loss…
A systematic review of Mendelian randomization evidence on alcohol-related phenotypes and multiple human diseases.
This systematic review synthesised Mendelian randomization studies using genetic variants as instruments for alcohol consumption, alcohol use disorder, or related measures to assess associations with health outcomes.
Complications of Poorly Fitted Scleral Lenses and Approaches to Continued Wear.
This case series highlights complications arising from poorly fitted scleral lenses (SLs) in patients with corneal irregularities and ocular surface diseases.
Herpes Simplex Necrotizing Stromal Keratitis After Femtosecond Laser-Assisted Cataract Surgery With Arcuate Keratotomies: A Case Report.
An 80-year-old woman with no known history of ocular herpes developed severe keratitis 15 days after uncomplicated femtosecond laser-assisted cataract surgery with paired arcuate keratotomies.
Bilateral Orbital Fat Hyperintensity in Early Glial Fibrillary Acidic Protein Astrocytopathy: A Case Report.
A 26-year-old woman presented with headache, fever, and bilateral ocular pain. MRI revealed hyperintensity in the bilateral orbital fat without optic nerve involvement, while initial intracranial MRI was unremarkable.
A prospective, randomized study comparing different therapeutic modalities for acute adenoviral conjunctivitis.
This prospective randomized study evaluated the effectiveness of three therapeutic modalities for acute adenoviral conjunctivitis in 65 patients.
Subconjunctival triamcinolone acetate versus topical steroid for control of inflammation after phacoemulsification surgery - A randomized control trial.
This randomized controlled trial compared the efficacy of subconjunctival triamcinolone acetate versus topical prednisolone for managing postoperative inflammation in 100 eyes after phacoemulsification surgery.
A Case of Adult-onset Presumed Congenital Syphilitic Keratitis: A Multidisciplinary Management Approach.
A 28-year-old man had an 11-year history of progressive bilateral redness, tearing, and visual decline. Examination showed bilateral interstitial keratitis; treponemal serology was positive and nontreponemal serology…
Biological mechanisms of atropine in myopia control (Review).
This systematic review examines the biological mechanisms of atropine in controlling myopia, a progressive disease affecting billions globally.
Patient-Reported Outcomes in Infectious Keratitis: A Systematic Review.
This systematic review evaluated patient-reported outcome measures (PROMs) used to assess quality of life (QoL) in patients with infectious keratitis.
Noncoding RNAs as novel diagnostic biomarkers for diabetic retinopathy: A systematic review and meta-analysis.
This systematic review and meta-analysis assessed the diagnostic accuracy of noncoding RNAs (ncRNAs) for diabetic retinopathy (DR), pooling 24 studies from 17 articles involving 1,983 patients and 1,437 controls.
Uncommon Concurrent Retinal and Cerebral Metastasis in High-risk Neuroblastoma: Diagnostic Utility of 68Ga-DOTATATE PET/CT Despite Negative 18F-FDG PET/CT.
A 5-year-old girl with high-risk neuroblastoma presented for surveillance with an 18F-FDG PET/CT, which showed two metabolically silent lesions in the right retina and brain.
Bilateral Exposure of EZYPOR Enucleation Implants.
A 72-year-old woman developed exposure of both porous polyethylene enucleation implants with suturing platforms (EZYPOR) after staged bilateral enucleations.
Conflicts of Interest Transparency, Study Outcomes, and Risk of Bias in Myopia Controlled Trials: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis examined whether conflict-of-interest (COI) disclosure transparency was associated with outcomes and methodological quality in randomized trials of myopia-control interventions…
Downbeat nystagmus: a practical approach based on a clinical case.
Spontaneous downbeat nystagmus (DBN) is the most common form of acquired nystagmus, characterized by a slow upward ocular drift and a corrective downward quick phase.
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