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1602 articles
November 202624
Arterial-to-End-Tidal CO₂ Gradient Direction as a Differential Diagnostic Clue During Sudden Hypercapnia in Thoracoscopic Surgery with Capnothorax: A Report of 2 Cases.
Two men undergoing thoracoscopic surgery with CO₂ insufflation developed abrupt rises in end-tidal CO₂ (EtCO₂). In the first, the rise coincided with severe hypotension and bradycardia; arterial blood gas showed PaCO₂…
Multidisciplinary management of disseminated tuberculosis with tuberculous meningitis and active hepatitis B in a critically ill pregnant woman in the third trimester: a case report.
A 24-year-old woman at 30 weeks’ gestation presented with headache, vomiting, fever, and nuchal rigidity. Cerebrospinal fluid findings confirmed tuberculous meningitis, and chest CT showed diffuse miliary nodules…
Efficacy and safety of apixaban versus rivaroxaban in acute venous thromboembolism: a systematic review and meta-analysis.
This systematic review and random-effects meta-analysis compared apixaban with rivaroxaban for acute venous thromboembolism in adults.
Rheumatoid factor positivity in ANCA-negative eosinophilic granulomatosis with polyangiitis: cardiac mimicry, mononeuritis multiplex, and long-term outcome in a case-based systematic review.
A 42-year-old woman with long-standing asthma and rheumatoid factor (RF) of 322 IU/mL presented with myocardial infarction-like cardiac involvement despite non-obstructive coronary arteries.
Fetal myelomeningocele repair: Rome Fondazione Policlinico A. Gemelli IRCCS experience.
A fetus with distal lumbar myelomeningocele was assessed by fetal MRI, which showed a 23 × 11-mm defect, ventricular dilatation, and Chiari II malformation. Open fetal repair was performed at 25 weeks of gestation.
Whole-grain consumption and cardiometabolic risk: a meta-analysis of randomized trials.
This meta-analysis of randomized trials assessed how whole-grain intake affects cardiometabolic risk factors. It included 87 trials (101 publications) and estimated effects per 48 g/day increment in whole grains (dry…
Loberamisal for Acute Ischemic Stroke: The LAIS Randomized Clinical Trial.
The LAIS trial was a multicenter, double-blind, randomized, placebo-controlled phase 3 study at 32 hospitals in China. It enrolled adults aged 18 to 80 years with acute ischemic stroke, treated within 48 hours, and…
Brain MRI changes following continuous positive airway pressure therapy in adults with obstructive sleep apnea: a systematic review.
This systematic review synthesized longitudinal brain MRI studies in adults with obstructive sleep apnea (OSA) before and after continuous positive airway pressure (CPAP), including comparisons with control groups.
Slow-wave sleep mediates the compensatory effects of acute moderate-intensity exercise on declarative memory deficits in sleep restriction.
This randomized controlled trial tested whether one session of moderate-intensity exercise could protect declarative memory during sleep restriction and whether slow-wave sleep (SWS) mediated any benefit.
Micro-axial flow pump vs veno-arterial extracorporeal membrane oxygenation for high-risk percutaneous coronary interventions: a randomized trial.
This prospective, multicentre, randomised, open-label non-inferiority trial compared prophylactic SynFlow 3.0 micro-axial flow pump support with VA-ECMO during non-emergent high-risk PCI in patients with complex…
Commonly experienced acute and cumulative 8-hour sleep loss differentially affect simulated driving during a night-time to early-morning commute: a randomized controlled crossover trial.
This randomized within-subject crossover trial compared simulated driving after normal sleep, four nights with 2 h less sleep per night, and one night without sleep in 20 healthy men.
Effectiveness of guided internet-delivered cognitive behavioral therapy for insomnia in autistic adults (i-Sleep Autism): a randomized controlled trial.
This randomized controlled trial evaluated a 5-week, guided internet-delivered cognitive behavioral therapy intervention adapted for autistic adults with insomnia.
Impact of nasogastric administration using the simple suspension method on serum tirabrutinib levels: A case report.
An 82-year-old man with relapsed primary central nervous system lymphoma began tirabrutinib at 320 mg/day while fasting. As dysphagia progressed, administration changed from swallowing tablets to nasogastric delivery by…
Outcomes in the BETAMI-DANBLOCK trial compared with a Norwegian nationwide myocardial infarction population.
This transportability analysis compared participants in the BETAMI and DANBLOCK randomized trials with revascularized Norwegian patients who had myocardial infarction, LVEF ≥40%, and no heart failure.
A nurse-coordinated intervention programme vs standard of care after an acute coronary syndrome: the ALLEPRE trial.
The multicentre, pragmatic, randomized ALLEPRE trial compared a nurse-coordinated prevention programme with hospital standard care in patients recovering from acute coronary syndrome.
Cardiovascular outcomes of glucagon-like peptide-1 receptor agonists: A systematic review.
This systematic review evaluated 12 cardiovascular outcome-based randomised controlled trials of GLP-1 receptor agonists (GLP1RAs): 10 in people with type 2 diabetes (T2D), one in people with overweight or obesity and…
Left bundle branch area vs biventricular pacing for cardiac resynchronization therapy: the LEFT-BUNDLE-CRT trial.
The multicentre, randomized, non-inferiority LEFT-BUNDLE-CRT trial compared left-bundle branch area pacing (LBBAP) with biventricular pacing (BiVP) for cardiac resynchronization in patients with guideline-based…
Sex differences in cardiovascular-kidney-metabolic syndrome: the FINE-HEART pooled analysis.
This prespecified pooled analysis combined participant-level data from three trials involving people with chronic kidney disease and type 2 diabetes or heart failure with mildly reduced or preserved ejection fraction.
Acupuncture after surgery of soft tissue tumors of the extremities: postoperative pain and feasibility: a prospective trial.
This prospective, single-arm, single-centre pilot study assessed acupuncture feasibility and postoperative pain after extremity soft tissue tumor resection in 25 patients.
Dirozalkib versus Crizotinib in Advanced Anaplastic Lymphoma Kinase Inhibitor-Naïve ALK -Positive Non-Small-Cell Lung Cancer: A Multicenter, Randomized Phase III Trial.
DIAMOND-2 was a multicenter, randomized, open-label phase III trial comparing dirozalkib with crizotinib in adults with ALK inhibitor-naïve, ALK-positive advanced non-small-cell lung cancer.
Combined Immunotherapy and Hybrid Dose-Fraction Radiotherapy for Driver-Negative Metastatic NSCLC: A Phase II Trial with Parallel Preclinical Studies.
This single-arm, multicenter phase II trial evaluated hybrid dose-fraction radiotherapy added during first-line chemoimmunotherapy maintenance in 83 patients with stage IV driver-negative metastatic NSCLC.
Impact of early versus delayed mobilization after arthroscopic rotator cuff repair in small and medium-sized tears: a prospective randomized study.
This prospective randomized study compared early with delayed mobilization after arthroscopic single-row knotless repair of small and medium full-thickness supraspinatus tears in 70 patients aged 20–70 years.
Effect of orofacial myofunctional therapy with auto-monitoring on the apnea-hypopnea index in patients with mild-to-moderate obstructive sleep apnea: a multicenter randomized controlled trial.
This multicenter randomized controlled trial assessed standardized orofacial myofunctional therapy (OMT) in treatment-naive adults with mild-to-moderate obstructive sleep apnea.
Spatial transcriptomics tumor microenvironment determinants of tyrosine kinase inhibitor response in renal cell carcinoma: results from a phase 2 clinical trial.
This phase 2 clinical trial examined whether spatially resolved tumor gene-expression patterns were associated with sunitinib response in 46 patients with metastatic clear cell renal cell carcinoma.
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