Trending archive
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1602 articles
October 202624
Expanding the molecular and phenotypic spectrum of MMP2-related multicentric osteolysis, nodulosis, and arthropathy: two brothers with marked intrafamilial variability and a review of the literature.
Two brothers, aged 14 and 8 years, from a consanguineous family had molecularly confirmed MMP2-related multicentric osteolysis, nodulosis, and arthropathy (MONA), with the same homozygous c.1648 C > T (p.Arg550Ter)…
Timing of intratracheal administration of budesonide mixed with surfactant to prevent bronchopulmonary dysplasia: a systematic review and meta-analysis.
This systematic review and meta-analysis examined randomised trials comparing intratracheal budesonide mixed with surfactant against surfactant alone in infants, assessing bronchopulmonary dysplasia (BPD) and whether…
What are the palliative and end-of-life care needs and preferences of people with cancer from culturally and linguistically diverse (CALD) backgrounds?: A systematic review.
This systematic review synthesised evidence on palliative and end-of-life care needs and preferences among people with cancer from culturally and linguistically diverse (CALD) backgrounds, and on factors affecting…
Methyl aminolevulinate-PpIX mediated fluorescence-guided mapping of high-grade vulvar intraepithelial neoplasia: a pilot prospective clinical trial (PhotoDiVin).
This prospective, single-centre, single-arm pilot clinical trial assessed methyl aminolevulinate-mediated fluorescence mapping in 17 women with histologically confirmed high-grade vulvar intraepithelial neoplasia (dVIN…
Robot-assisted minimally invasive versus conventional open transforaminal lumbar interbody fusion for lumbar degenerative disease: a prospective randomized controlled trial.
This prospective, single-centre, assessor-blinded randomized trial compared robot-assisted minimally invasive TLIF with conventional fluoroscopy-guided open TLIF in 128 patients with lumbar degenerative disease.
AI-facilitated individualized nutritional guidance with ABC-structured prompts improves short-term dietary intake adequacy and patient-reported symptoms after gastrointestinal cancer surgery: a randomized controlled trial.
This single-center randomized controlled trial compared AI-facilitated, individualized and quantified dietary guidance plus clinician review with standard discharge advice in 90 patients after laparoscopic gastric or…
Infantile posterior fossa atypical teratoid/rhabdoid tumor: navigating diagnostic complexity and molecular paradigms.
A female infant younger than 1 year presented with a massive cystic-solid posterior fossa tumor and rapidly developing obstructive hydrocephalus.
Levodopa or dopamine agonists for enhancing motor function after stroke.
This Cochrane systematic review and meta-analysis assessed whether levodopa or dopamine agonists improve motor function after stroke.
Maternity versus non-maternity healthcare settings for the diagnosis of gestational diabetes or diabetes in pregnancy.
This Cochrane systematic review and meta-analysis assessed whether maternity or non-maternity healthcare settings affect screening and diagnosis of gestational diabetes or diabetes in pregnancy.
Community-based nutrition interventions across the continuum of care in humanitarian settings: a systematic review and evidence map.
This systematic review and evidence map examined community-based nutrition interventions in humanitarian and emergency settings in low- and middle-income countries.
A 61-Year-Old Woman With Locally Advanced Pancreatic Adenocarcinoma Managed With Neoadjuvant FOLFIRINOX, Total Pancreatectomy, Splenectomy, Portal Vein and Common Hepatic Artery Resection, and Combined Vascular Reconstruction Using Splenic Artery Transposition: A Case Report.
A 61-year-old woman presented with progressive jaundice and CA 19-9 of 210 U/mL. Biopsy confirmed pancreatic ductal adenocarcinoma, and imaging showed portal vein and common hepatic artery involvement without distant…
Human milk oligosaccharide (2'-FL) modifies the gut microbiome in children after bone marrow transplant.
This prospective phase 1/2 clinical trial evaluated daily oral 2′-fucosyllactose (2′-FL), a human milk oligosaccharide, from conditioning through day +30 in children undergoing allogeneic hematopoietic stem cell…
Tagraxofusp, azacitidine, and venetoclax for blastic plasmacytoid dendritic cell neoplasm.
This phase 2 clinical trial evaluated tagraxofusp, azacitidine, and venetoclax in 27 patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN): 16 previously untreated and 11 with relapsed or refractory…
Vertebral fractures in a young woman: the impact of hypogonadism, glucocorticoids, and chronic disease.
A premenopausal woman developed painful vertebral fractures while receiving prednisolone for newly diagnosed systemic lupus erythematosus.
Expected change: a new concept for monitoring patients on oral bisphosphonates.
This randomized controlled trial evaluated ways to monitor response to oral bisphosphonates in 108 postmenopausal women younger than 85 years treated with alendronate, ibandronate, or risedronate, with calcium and…
Chlorhexidine within a standardized oral-care bundle for the prevention of ventilator-associated pneumonia: a pragmatic cluster-randomized crossover trial in six medical intensive care units.
This pragmatic cluster-randomized crossover trial in six adult medical ICUs at one Indian tertiary-care hospital compared a standardized oral-care bundle with the same bundle plus 0.12% chlorhexidine (CHX) in adults…
Ectopic cushing syndrome caused by intestinal neuroendocrine tumors: a systematic review.
This systematic review characterized ectopic Cushing syndrome caused by intestinal neuroendocrine tumors using published case reports and an illustrative unpublished case. It identified 24 published cases.
Double heterozygous pathogenic germline APC and MSH2 variants in a 16-year-old female diagnosed with colorectal cancer.
A 16-year-old female presented with multiple colonic polyps and invasive colorectal carcinoma. Genetic testing identified heterozygous pathogenic variants in both APC and MSH2, consistent with the genetic basis of…
Prevalence of depression and anxiety among patients with Behçet's disease: a systematic review and meta-analysis.
This systematic review and random-effects meta-analysis estimated depression and anxiety prevalence among patients with Behçet’s disease (BD).
BCMA-directed CAR T-cell therapy induces durable drug-free remission in refractory primary immune thrombocytopenia.
This phase I clinical trial evaluated B-cell maturation antigen (BCMA)-directed chimeric antigen receptor T-cell therapy in 4 patients with refractory primary immune thrombocytopenia.
Multiple Organ Failure Secondary to Pancreatitis Due to Biliary Ascariasis in a Young Patient: A Case Report on the Importance of a Good Anamnesis.
A 22-year-old man from rural Honduras presented in refractory shock with encephalopathy, jaundice, gastrointestinal bleeding, severe hepatic dysfunction, acute kidney injury, and rhabdomyolysis after taking large…
Analgesic efficacy of regional and local analgesic techniques for anterior cruciate ligament reconstruction in adults undergoing general anesthesia: a systematic review and network meta-analysis.
This systematic review and Bayesian network meta-analysis compared regional and local analgesic techniques in adults undergoing anterior cruciate ligament reconstruction under general anesthesia.
Performance of 0/1 h versus 0/3 h pathways in patients with suspected myocardial infarction: a systematic review and individual participant data meta-analysis of randomised controlled trials.
This systematic review and individual participant data meta-analysis combined five randomised trials comparing 0/1 h with 0/3 h cardiac troponin pathways in patients presenting with suspected myocardial infarction.
An intervention based on acceptance and commitment therapy for people experiencing work- or career-related difficulties: A randomized controlled trial.
This randomized controlled trial evaluated a seven-session online group intervention based on acceptance and commitment therapy among people experiencing work- or career-related difficulties, including job loss and…
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