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1602 articles
November 202624
An Infant With Extreme Hypernatremia Treated With Peritoneal Dialysis.
A 34-day-old, 3.6-kg male infant developed serum sodium >200 mmol/L and multiple organ dysfunction after accidental salt poisoning.
Implementing Respiratory Illness Care Pathways in General Hospitals: A Cluster Randomized Trial.
This pragmatic, multicenter cluster-randomized trial evaluated implementation of inpatient pathways for asthma, pneumonia, and bronchiolitis in US general hospitals.
Sleep Management and Recovery After TBI in Kids (SMART-Kids): Pilot Trial Using Melatonin.
This pilot randomized, double-blinded, placebo-controlled trial assessed early melatonin plus sleep education in children aged over 6 to 18 years hospitalized after traumatic brain injury (TBI).
ChatGPT and Other Large Language Models in Inflammatory Arthritis: A Systematic Review Across Clinical Tasks.
This systematic review assessed large language model performance across clinical tasks in inflammatory arthritis. It included 18 studies spanning rheumatoid arthritis, axial spondyloarthritis, psoriatic arthritis, gout…
Do People With Tophaceous Gout Require More Allopurinol for Good Clinical Outcomes? Analysis of 2 Randomized Controlled Trials of Allopurinol Dose Escalation.
This analysis of individual participant data from two randomized allopurinol dose-escalation trials compared outcomes in people with gout with and without baseline tophi.
Effect of Bimekizumab Treatment on Health Status, Work Productivity, and Productivity Costs Through 3 Years in Axial Spondyloarthritis and Psoriatic Arthritis.
This analysis assessed health status, work productivity, and productivity-related costs through 3 years among patients with axial spondyloarthritis (axSpA) or psoriatic arthritis (PsA) treated with bimekizumab in phase…
Airway occlusions to measure inspiratory effort, respiratory drive, and lung mechanics during noninvasive ventilation.
This multicenter randomized study assessed whether airway occlusion maneuvers can estimate inspiratory effort, respiratory drive, and lung mechanics during noninvasive ventilation (NIV).
Clinical significance of isolated periappendiceal red patch in ulcerative colitis: A systematic review, meta-analysis, and meta-regression.
This systematic review and meta-analysis examined whether an isolated periappendiceal red patch (PARP) is associated with disease extent or outcomes in ulcerative colitis.
Biologics and small molecules for perianal Crohn's disease: a systematic review and meta-analyses of randomized placebo-controlled trials.
This systematic review and meta-analysis pooled placebo-controlled randomized trials of advanced therapies for perianal fistulizing Crohn’s disease.
PURE PRIME: implementing Pulmonary Rehabilitation in Primary care - a randomized-controlled feasibility trial.
PURE PRIME was a randomized controlled feasibility trial testing pulmonary rehabilitation (PR) in private physiotherapy or exercise physiology practices for people with chronic respiratory disease.
Mycobacterium abscessus bacteremia: A narrative literature review based on a case report.
The report describes a catheter-associated bloodstream infection caused by Mycobacterium abscessus subsp. massiliense. The authors also reviewed published M.
Salivary biomarkers in periodontal diseases: A systematic review.
This systematic review assessed salivary biomarkers for diagnosing and monitoring periodontitis in systemically healthy people. It included 11 human studies with cross-sectional or interventional designs.
Six-Month Music Practice Versus Psychomotor Interventions in Mild Cognitive Impairment: Behavioral and Hippocampal Outcomes.
This pilot randomized controlled intervention study compared six months of intensive musical instrument training with psychomotor interventions in people with mild cognitive impairment (MCI), using matched healthy…
Optimal Exercise Dose for Improving Multidimensional Health Outcomes in Colorectal Cancer Patients: A Systematic Review, Meta-Analysis and Meta-Regression.
This systematic review, meta-analysis and meta-regression examined exercise dose-response relationships in colorectal cancer patients.
Excellent Long-Term Outcome in a Staged, Simultaneous Liver-Kidney Transplantation of a Highly Sensitized Pediatric Patient With B and T Cell Positive Crossmatch.
A highly sensitized small child with high-titer class I and II donor-specific antibodies underwent staged simultaneous liver-kidney transplantation from the same donor despite a positive cytotoxic crossmatch.
The Cognitive Functions of Youth With Obesity: A Meta-Analysis.
This PRISMA-guided meta-analysis pooled 22 studies comparing youth under 18 with obesity and normal-weight peers, using random-effects models to assess seven cognitive domains.
Plasma Lipidomic Features of Adolescent Major Depressive Disorder and Lipid Changes After Fluoxetine Treatment.
This clinical trial study used UHPLC-MS/MS to compare plasma lipid profiles in 75 adolescents with major depressive disorder (MDD) and 75 matched healthy controls, and to assess changes after fluoxetine in 44…
Telehealth Treatment of Anxiety in Patients With Low-Risk Chest Pain in the Emergency Department: The PACER Randomized Clinical Trial.
The PACER multicentre, three-group randomised comparative effectiveness trial tested peer-supported internet-based cognitive behavioural therapy (iCBT) and therapist-delivered telehealth CBT against primary care…
Efficacy of Technology-Augmented Behavioral Counseling for Risky Firearm Behaviors: A Randomized Clinical Trial.
This two-arm randomized clinical trial tested IntERact, a 30-day program combining telehealth behavioral counseling and tailored smartphone content, against enhanced usual care among 373 emergency department patients…
The two-shot protocol. A randomized controlled trial of a novel two-injection ovarian stimulation strategy.
This phase III, single-centre randomised non-inferiority trial compared two sequential corifollitropin alfa (CFA) injections with conventional CFA followed by recombinant FSH in women undergoing elective fertility…
RSV Bivalent Prefusion F Protein Vaccine in Pregnancy and Protection Against RSV-Associated Illness in Infants: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed real-world effectiveness of maternal RSV bivalent prefusion F protein vaccination in preventing RSV-associated lower respiratory tract infection (LRTI) hospitalization…
Specialist Referral for Cardiovascular Risk in Patients With Prostate Cancer: A Randomized Clinical Trial.
This multicenter randomized clinical trial tested whether routine cardiovascular-specialist referral improved risk-factor control and cardiovascular outcomes in patients with prostate cancer who were starting or had…
Intravenous lidocaine does not provide additional pain reduction beyond placebo in probable nociplastic chronic low back pain: a randomized controlled equivalence trial.
This randomized, placebo-controlled equivalence trial assessed repeated intravenous lidocaine in 84 adults with chronic non-specific low back pain and probable nociplastic pain features.
Dexamethasone Eye Drops to Prevent Treatment-Requiring Retinopathy of Prematurity: The DROPROP Randomized Clinical Trial.
The DROPROP double-masked, multicentre randomised clinical trial tested whether topical dexamethasone could prevent progression to treatment-requiring type 1 retinopathy of prematurity (ROP) in preterm infants born…
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