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1602 articles
November 202624
An Approach to Acute Cranial Symptoms in Primary Care: Lesson From a Case of Miller Fisher Syndrome.
A 38-year-old woman developed acute diplopia, right eye pain, headache, and perioral numbness two weeks after an upper respiratory infection.
Effect of topical insulin in diabetic foot ulcer healing among patients with diabetes in Asia: a systematic review.
This systematic review assessed topical insulin for diabetic foot ulcer healing in patients with diabetes in Asian countries.
Oral administration of parenteral S-ketamine in wound care when 'conventional' medication regimens are not sufficient: a case series.
A case series described four patients whose pain during wound care was not adequately controlled by conventional medication regimens.
Clinical effectiveness and safety of bacterial cellulose dressings in the management of skin wounds: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed the efficacy and safety of bacterial cellulose dressings compared with conventional treatments for skin wounds.
Low-level laser therapy in ulcerative lesions in leprosy: a systematic review.
This systematic review assessed whether low-level laser therapy (LLLT) improves healing of ulcerative lesions in people with leprosy.
Orthoplastic Limb Salvage Using Transtibial Transport and Free-Flap Reconstruction in Patients With Diabetes-Related Chronic Limb-Threatening Ischemia.
A 56-year-old man with poorly controlled diabetes and severe peripheral arterial disease developed a chronic foot ulcer with toe gangrene despite unsuccessful revascularization, leaving no conventional revascularization…
Caring Contacts and Suicidality Among American Indian and Alaska Native Communities: A Randomized Clinical Trial.
The CARE study was a blinded, two-group randomized clinical trial of 709 American Indian and Alaska Native adults with active suicidality across five communities.
Cost-Effectiveness of Remote Symptom Monitoring During Adjuvant Endocrine Therapy in Breast Cancer.
This economic evaluation used data from a randomized trial of adult women initiating adjuvant endocrine therapy for early-stage breast cancer, comparing remote symptom monitoring via an app, an app with tailored…
Proteomic and Metabolomic Profiling in Moyamoya Disease: A Systematic Review.
This systematic review examined human studies using high-throughput proteomic or metabolomic methods on serum or cerebrospinal fluid in Moyamoya disease (MMD). Of 3,071 records identified, 31 studies were included.
The risk of rhegmatogenous retinal detachment associated with topical pilocarpine: a systematic review.
This systematic review assessed whether topical pilocarpine is associated with rhegmatogenous retinal detachment (RRD) in patients aged 40 years or older, synthesising 10 comparative studies.
Dapagliflozin attenuates progression from prefrailty to frailty in patients with hypertension and chronic kidney disease.
DAPA-FORTRESS followed prefrail hypertensive adults aged over 65 years with chronic kidney disease (CKD) for 1 year to examine links between renal measures and physical performance, and whether dapagliflozin was…
Neoadjuvant PD-L1/TGF-β blockade can rapidly disrupt the tumor stroma in head and neck cancer patients.
This window-of-opportunity clinical study examined neoadjuvant bintrafusp alfa, a dual PD-L1 and TGF-β inhibitor, in patients with head and neck squamous cell carcinoma.
Selective Electrical Muscle Stimulation of the Vastus Medialis in a Patient With Knee Osteoarthritis, With Changes in Muscle Quality, Symptoms, and Physical Activity: A Case Report.
A 77-year-old man with Kellgren-Lawrence grade 2 right knee osteoarthritis had stopped regular exercise, including aquatic walking, because of knee pain.
Neoadjuvant concurrent or sequential anthracycline-containing chemotherapy and HER2-targeted agents for HER2-positive breast cancer: a randomized phase 2 study (METIS).
The randomized phase II METIS trial compared neoadjuvant pegylated liposomal doxorubicin (PLD)-based chemotherapy given concurrently with trastuzumab and pertuzumab against sequential epirubicin/cyclophosphamide-based…
Short-term bioavailability of EPA and DHA from an algae oil-fortified soymilk compared with algae oil capsules.
This 4-week, open-label, randomized parallel trial compared short-term EPA and DHA bioavailability from algae oil-fortified soymilk with algae oil capsules in 21 healthy adults.
Microbiota-derived urolithins and cortical thickness in cognitively healthy older adults: a longitudinal MRI analysis of the WAHA trial.
This longitudinal MRI sub-study within the randomized WAHA trial examined whether changes in urinary microbiota-derived urolithins tracked with cortical-thickness changes in cognitively healthy older adults.
Autologous Blood Pleurodesis for Postoperative Air Leakage Following Video-Assisted Thoracoscopic Surgery-A Randomized Controlled Trial.
This multicentre randomised controlled trial assessed early autologous blood pleurodesis (ABP) for postoperative air leakage after elective video-assisted thoracoscopic surgery.
Fucoidan as an anti-inflammatory and immunomodulatory agent in humans: a systematic review of clinical evidence and translational potential.
This systematic review assessed human interventional studies of fucoidan supplementation for inflammatory, immune, metabolic, and tumour-related outcomes.
Optimizing the Therapeutic Index: Sequential Intraarterial-Intravenous PRRT with Personalized Volumetric-Adjusted Dosing.
This prospective clinical trial assessed a personalized sequence of intraarterial then intravenous 177Lu-DOTATATE in 10 adults with progressive, nonresectable, liver-dominant metastatic gastroenteropancreatic…
Sunlight Exposure and Breast Cancer Risk: A Systematic Review and Meta-analysis.
This systematic review and random-effects meta-analysis combined 31 epidemiologic studies to assess sunlight exposure and breast cancer incidence, subtype, and survival.
Changes in Alcohol Use among Adults with Cancer Participating in the ECOG-ACRIN EAQ171CD Tobacco Treatment Trial.
This post hoc analysis of the randomized ECOG-ACRIN EAQ171CD tobacco-treatment trial examined alcohol-risk changes among 305 adults with cancer who smoked, comparing virtual sustained treatment (VST) with enhanced usual…
Extended Follow-up of Botensilimab plus Balstilimab in an Expanded Cohort of Microsatellite-Stable Metastatic Colorectal Cancer without Active Liver Metastases.
This phase Ib clinical trial evaluated botensilimab plus balstilimab in patients with previously treated microsatellite-stable metastatic colorectal cancer without active liver metastases.
A Phase I First-Time-in-Human, Open-label Study of Nelistotug Administered to Patients with Advanced Solid Tumors.
This first-in-human, open-label, nonrandomized, multicenter phase I study evaluated nelistotug, an anti-CD96 antibody, alone or with dostarlimab, and in a three-drug combination with dostarlimab and belrestotug in…
EMB-01, an Anti-EGFR/c-MET Bispecific Antibody, in Patients with Heavily Pretreated Metastatic Colorectal Cancer from a Phase Ib/II, Open-Label, Multicenter Study.
This phase Ib/II, open-label, multicenter study evaluated weekly intravenous EMB-01, an EGFR/c-MET bispecific antibody, in patients predominantly with heavily pretreated metastatic colorectal cancer (mCRC).
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