Oral administration of parenteral S-ketamine in wound care when 'conventional' medication regimens are not sufficient: a case series.
Valerie Mm van Meegen, Tessa Engels, Brigitte A Brouwer et al.
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Case in brief
A case series described four patients whose pain during wound care was not adequately controlled by conventional medication regimens. They received oral parenteral S-ketamine at 0.5-1mg/kg during wound care on the ward, with successful treatment reported. No changes in respiratory function or haemodynamics were observed. One patient experienced a dissociative state, which neither the patient nor caregivers considered negative. The authors noted reduced pain and improved patient satisfaction, while emphasizing that further research on dose, efficacy and safety in larger patient groups is needed.
What made this case unusual
The parenteral formulation of S-ketamine was administered orally during ward-based wound care, rather than using sedation or general anaesthesia.
Diagnostic / clinical pearl
Oral parenteral S-ketamine was reported as a successful option for wound-care pain in these four cases, without observed respiratory or haemodynamic changes; the small case series does not establish broader safety or efficacy.