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2000 articles
November 202624
Eltrombopag during induction chemotherapy in older patients with newly diagnosed acute myeloid leukemia is safe and reduces platelet transfusion requirements: The EPAG-2015 French Innovative Leukemia Organization phase 2 randomized trial.
The multicentre, phase 2 randomized trial EPAG-2015 evaluated eltrombopag started after induction chemotherapy in patients aged 60 years or older with newly diagnosed acute myeloid leukemia.
False-Positive Prenatal Suspicion of Partial Anomalous Pulmonary Venous Connection: A Benign Confluence Variant Clarified by Cardiac CT.
Prenatal ultrasound raised suspicion of partial anomalous pulmonary venous connection (PAPVC). After birth, echocardiography—limited by acoustic windows and influenced by the prenatal interpretation—also suggested…
Specialist Referral for Cardiovascular Risk in Patients With Prostate Cancer: A Randomized Clinical Trial.
This multicenter randomized clinical trial tested whether routine cardiovascular-specialist referral improved risk-factor control and cardiovascular outcomes in patients with prostate cancer who were starting or had…
Transformation to Small-Cell Lung Carcinoma and Then to Sarcomatoid Carcinoma in an EGFR-Mutant Lung Adenocarcinoma Patient During Systemic Therapy: A Case Report.
A patient with EGFR-mutant lung adenocarcinoma developed resistance to osimertinib with transformation to combined small-cell lung carcinoma.
Adults With Type 1 Diabetes Are Less Physically Active Than Adults Without Diabetes: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis compared physical activity and sedentary behaviour in adults with type 1 diabetes and adults without diabetes.
Systematic Review of Smart Home Assistive Technology Devices for Supporting People With Dementia Living in Their Homes.
This systematic review and meta-analysis assessed smart home and wearable assistive technologies for people with dementia living at home or in supported accommodation.
Impact of Aspirin Use on Mortality and Cardiac Allograft Vasculopathy After Heart Transplantation: A Systematic Review and Meta-analysis.
This systematic review and meta-analysis examined whether aspirin use was associated with mortality and cardiac allograft vasculopathy (CAV)-related outcomes in heart transplant recipients.
Exercise and Nutritional Interventions for Muscle Strength, Physical Performance, and Body Composition Among Older Adults With Sarcopenia or Pre-Sarcopenia: A Network Meta-Analysis.
This network meta-analysis compared exercise, nutritional, and combined interventions with control strategies in older adults with sarcopenia or pre-sarcopenia.
Effects of Integrated Multicomponent Care on Older Adults With Frailty or Pre-Frailty: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed integrated multicomponent care (IMC) for older adults with frailty or pre-frailty, including evidence from 20 randomised and quasi-experimental studies.
Plasma Lipidomic Features of Adolescent Major Depressive Disorder and Lipid Changes After Fluoxetine Treatment.
This clinical trial study used UHPLC-MS/MS to compare plasma lipid profiles in 75 adolescents with major depressive disorder (MDD) and 75 matched healthy controls, and to assess changes after fluoxetine in 44…
Can Clinicians Predict Which Patients Respond Best to a Specific Treatment? A Systematic Review of Low Back Pain Moderators in Primary Care.
This systematic review synthesized randomized trials and secondary analyses examining whether patient characteristics modify responses to primary care interventions for nonspecific low back pain.
Association of Caregiver Mental Health and a Childhood Parenting Intervention in China.
This clustered randomized controlled trial tested whether caregiver mental health modified the effects of a center-based parenting intervention in 100 rural Chinese villages.
Single-Stage Bilateral Microsurgical Treatment of Five Complex Unruptured Anterior Circulation Aneurysms Assisted by Rapid Ventricular Pacing: Case Report and Literature Review.
A 54-year-old woman with untreated hypertension and active smoking presented with a pupil-involving left oculomotor nerve palsy.
Therapeutic Horseback Riding for Youth With Autism and Psychiatric Comorbidities: A Randomized Trial.
This multisite randomized controlled trial evaluated equine-assisted activities in youth aged 6–16 years with autism and psychiatric comorbidity.
Paxalisib with Trastuzumab for HER2-Positive Metastatic Breast Cancer with Active Brain Metastases: A Phase II Trial with Integrated Plasma and CSF ctDNA Analyses.
This phase II trial evaluated brain-penetrant paxalisib plus trastuzumab in patients with active or progressive HER2-positive breast cancer brain metastases, including heavily pretreated patients; leptomeningeal disease…
Preoperative Temporal Elevation of Cytokeratin 19 Fragment in Thymoma With Extensive Necrosis: A Case Report.
A 73-year-old man presented with chest pain, and CT showed a mediastinal mass with pleural effusion. White blood cell count, C-reactive protein, and cytokeratin 19 fragment (CYFRA) were elevated; CYFRA was 61.3 ng/mL.
Excellent Long-Term Outcome in a Staged, Simultaneous Liver-Kidney Transplantation of a Highly Sensitized Pediatric Patient With B and T Cell Positive Crossmatch.
A highly sensitized small child with high-titer class I and II donor-specific antibodies underwent staged simultaneous liver-kidney transplantation from the same donor despite a positive cytotoxic crossmatch.
Long-Term Marginal Bone Stability of BOPT Restorations on Bone-Level vs. Tissue-Level Implants: An 8-Year Prospective Clinical Study.
This prospective randomized clinical study compared eight-year marginal bone loss in 122 posterior bone-level and tissue-level implants restored using the Biologically Oriented Preparation Technique (BOPT) in 71…
Effects of Multicomponent Training on Body Composition and Cardiorespiratory Fitness in Adults With Type 2 Diabetes: A Randomized Controlled Trial.
This randomized controlled trial assessed 14 weeks of small-sided soccer training in adults aged 40–70 years with type 2 diabetes.
Six-Month Music Practice Versus Psychomotor Interventions in Mild Cognitive Impairment: Behavioral and Hippocampal Outcomes.
This pilot randomized controlled intervention study compared six months of intensive musical instrument training with psychomotor interventions in people with mild cognitive impairment (MCI), using matched healthy…
Prevalence of Diabetes in Low- and Middle-Income Countries' Incarcerated Populations: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis estimated diabetes prevalence among incarcerated people in low- and middle-income countries (LMICs), drawing on 23 studies with 107,473 participants.
Effectiveness of Traditional Chinese Fitness Methods on Depressive Symptoms and Glycaemic Control in Patients With Type 2 Diabetes and Comorbid Depression: A Systematic Review and Meta-Analysis of Taijiquan and Baduanjin.
This systematic review and meta-analysis assessed randomised controlled trials of Taijiquan and Baduanjin in people with type 2 diabetes and comorbid depression. Eight trials, all conducted in China, were included.
First-in-Human Regulatory T Cell-Derived Exosomes Plus Ranibizumab for Refractory nAMD.
This single-centre, prospective, open-label phase 1a dose-escalation trial evaluated the safety and maximum tolerated dose of intravitreal autologous regulatory T cell-derived exosomes (TregExo) coformulated with…
Diagnosis and Management of Achalasia in Children, BSPGHAN and BAPS Consensus Statement.
This consensus statement addresses diagnosis and management of achalasia in children, for whom pediatric-specific guidelines were lacking.
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