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2000 articles
November 202624
Liposomal irinotecan and capecitabine plus bevacizumab as second-line therapy in metastatic colorectal cancer: A multicenter, single-arm study.
This multicenter, single-arm clinical study evaluated liposomal irinotecan, capecitabine, and bevacizumab as second-line therapy in patients with metastatic colorectal cancer progressing after oxaliplatin-based…
Five-year outcomes of the STOP-AD randomised controlled trial: Long-term effects of early emollient therapy in high-risk infants.
This blinded, single-centre, randomised controlled trial follow-up assessed whether brief neonatal emollient use was associated with lasting effects on atopic dermatitis (AD) in term infants at high risk of AD.
Do People With Tophaceous Gout Require More Allopurinol for Good Clinical Outcomes? Analysis of 2 Randomized Controlled Trials of Allopurinol Dose Escalation.
This analysis of individual participant data from two randomized allopurinol dose-escalation trials compared outcomes in people with gout with and without baseline tophi.
Effect of Exercise Interventions on Sarcopenia-Related Outcomes in Older Adults With Type 2 Diabetes: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed structured exercise versus nonexercise control in adults with type 2 diabetes whose mean age was at least 65 years.
Sociodemographic factors, but not rurality, explain limited variance in fibromyalgia severity: a secondary analysis of 2 randomized clinical trials.
This secondary analysis combined baseline data from 685 participants in two randomized clinical trials to examine whether rural residence and sociodemographic characteristics were associated with fibromyalgia severity.
Transcranial Pulse Stimulation in Parkinson's Disease: A Systematic Review.
This systematic review assessed clinical, neurophysiological, imaging, and safety outcomes of transcranial pulse stimulation (TPS) in adults with idiopathic Parkinson’s disease.
Genotypic-Phenotypic Correlations in Non-HbE β-Thalassemia Intermedia: A Geographic Systematic Review.
This PRISMA-guided systematic review qualitatively synthesized 21 studies of genotype–phenotype correlations in non-HbE β-thalassemia intermedia, a heterogeneous disorder now included within non-transfusion-dependent…
A comparison of the efficacy and safety of direct oral anticoagulants with low molecular weight heparin for venous thromboembolism prophylaxis after total hip arthroplasty : a systematic review and meta-analysis.
This systematic review and meta-analysis compared direct oral anticoagulants (DOACs) with low molecular weight heparin (LMWH) for venous thromboembolism prophylaxis after elective total hip arthroplasty.
Dual Remission of Atopic Dermatitis and Frequently Relapsing Nephrotic Syndrome With Dupilumab.
A 9-year-old girl had atopic dermatitis and frequently relapsing, steroid-sensitive nephrotic syndrome, with relapses increasing despite treatment with two immunosuppressants.
Effects of CT-guided Radiofrequency Versus Microwave Ablation on Pulmonary Function in Individuals with Pulmonary Tumors: A Prospective Multicenter Randomized Trial.
This prospective, multicenter randomized trial compared short-term pulmonary function after CT-guided radiofrequency ablation (RFA) or microwave ablation (MWA) in 138 participants with pulmonary tumors.
Polyneuropathy, Organomegaly, Endocrinopathy, M-Protein, and Skin Changes (POEMS) Syndrome With Characteristic Muscle Biopsy Findings and Without M-Protein.
A 63-year-old woman referred with presumed CIDP had not responded to IVIG or steroids. Her presentation included marked weight loss, papilledema, skin changes, thrombocytosis, thromboembolisms, hemi-diaphragmatic…
Implementing Respiratory Illness Care Pathways in General Hospitals: A Cluster Randomized Trial.
This pragmatic, multicenter cluster-randomized trial evaluated implementation of inpatient pathways for asthma, pneumonia, and bronchiolitis in US general hospitals.
ChatGPT and Other Large Language Models in Inflammatory Arthritis: A Systematic Review Across Clinical Tasks.
This systematic review assessed large language model performance across clinical tasks in inflammatory arthritis. It included 18 studies spanning rheumatoid arthritis, axial spondyloarthritis, psoriatic arthritis, gout…
Structural Brain Correlates of Bulimia Nervosa Diagnosis and Symptom Severity: A Coordinated ENIGMA Eating Disorders Working Group Analysis.
This coordinated, international case-control meta-analysis examined structural MRI correlates of bulimia nervosa (BN) diagnosis and symptom severity across 17 cohorts at 13 sites.
Dexamethasone Eye Drops to Prevent Treatment-Requiring Retinopathy of Prematurity: The DROPROP Randomized Clinical Trial.
The DROPROP double-masked, multicentre randomised clinical trial tested whether topical dexamethasone could prevent progression to treatment-requiring type 1 retinopathy of prematurity (ROP) in preterm infants born…
Clinical Trajectory of Late-Onset Delusional Disorder Toward Evolving Dementia With Lewy Bodies.
The report revisited four clinicopathological cases in which late-onset delusional disorder was the initial manifestation of Lewy body disease.
Effect of Bimekizumab Treatment on Health Status, Work Productivity, and Productivity Costs Through 3 Years in Axial Spondyloarthritis and Psoriatic Arthritis.
This analysis assessed health status, work productivity, and productivity-related costs through 3 years among patients with axial spondyloarthritis (axSpA) or psoriatic arthritis (PsA) treated with bimekizumab in phase…
Intravenous lidocaine does not provide additional pain reduction beyond placebo in probable nociplastic chronic low back pain: a randomized controlled equivalence trial.
This randomized, placebo-controlled equivalence trial assessed repeated intravenous lidocaine in 84 adults with chronic non-specific low back pain and probable nociplastic pain features.
Anti-Contactin-1 Nodopathy Presenting With Dysphagia and Nephrotic Syndrome: Remarkable Neurological and Renal Recovery Following Early B-Cell-Targeted Therapy.
A 77-year-old man with diabetes and pre-existing heavy proteinuria developed rapidly progressive distal numbness, weakness, sensory ataxia, mild dysphagia, and functional decline.
Clinical significance of isolated periappendiceal red patch in ulcerative colitis: A systematic review, meta-analysis, and meta-regression.
This systematic review and meta-analysis examined whether an isolated periappendiceal red patch (PARP) is associated with disease extent or outcomes in ulcerative colitis.
An Adolescent With Neurosyphilis.
A previously healthy 17-year-old boy developed two weeks of myoclonus affecting his right thumb and middle finger, followed by focal seizures in the right arm that generalized.
Clinical outcomes and euploidy rates of embryos derived from zygotes with nonpronuclear (0PN) and monopronuclear (1PN) in IVF or ICSI cycles: a systematic review and meta-analysis.
This systematic review and meta-analysis compared euploidy and clinical outcomes for embryos derived from 0PN or 1PN zygotes with those from normally fertilized 2PN zygotes in IVF/ICSI cycles.
Q-switched Nd:YAG Laser for Extrafacial Lichen Planus Pigmentosus: A Case Series Highlighting Outcomes and Risks.
Three patients with biopsy-proven lichen planus pigmentosus (LPP) involving facial and extrafacial sites received Q-switched neodymium:yttrium aluminum garnet laser treatment.
Performance of the i-Gel Versus King LT-D by Combat Medics Under Simulated Tactical Conditions: A Prospective Randomized Crossover Study.
This prospective randomized crossover study compared i-gel and King LT-D placement by active-duty combat medics after exertion while wearing full combat gear, using a high-fidelity manikin.
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