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2000 articles
November 202624
Rare Sites of Metastases to the Breast and Integumentary System in Advanced Cervical Cancer at Initial Presentation in Eastern Uganda: A Case Report.
A 72-year-old woman in Uganda presented after 13 months of intermittent postmenopausal bleeding and abnormal vaginal discharge, despite repeated treatment for presumed urinary and sexually transmitted infections.
Duodenal Adenocarcinoma Recurrence Limited to the Choledochojejunostomy After Pancreaticoduodenectomy: A Case Suggesting Intraluminal Implantation With a Distinct Mucin Phenotypic Shift.
A 59-year-old man developed recurrence at the choledochojejunostomy 27 months after pancreaticoduodenectomy for duodenal adenocarcinoma, despite five surgically created raw surfaces.
A phase Ia first-in-human study of BPB-101, a novel trifunctional antibody targeting the GARP/TGF-β complex and PD-L1, in patients with locally advanced or metastatic solid tumors.
This phase Ia, multicenter, first-in-human dose-escalation study evaluated BPB-101, a trifunctional antibody targeting the GARP/TGF-β complex and PD-L1, in previously treated patients with advanced or metastatic solid…
Colonoscopy surveillance after colorectal cancer surgery: meta-analysis.
This systematic review and meta-analysis examined randomized trials comparing follow-up protocols with versus without colonoscopy within 5 years after colorectal cancer surgery.
Predictive Accuracy and Procedural Benefits of Software-Enhanced Flow-Diverter Planning: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed whether software simulations improve flow-diverter (FD) planning and procedural outcomes for intracranial aneurysms compared with physician planning.
Metagenomic Next-Generation Sequencing of Mycoplasma hominis Infection in an Immunocompromised Patient: A Case Report.
A 52-year-old immunocompromised man developed persistent soft-tissue infection after a wooden splinter injury, with recurrent fever, wound pain, swelling, and exudation.
Co-Designed Text Messaging Intervention for Parents of Children With Early Childhood Caries: Randomized Controlled Trial.
This multisite, assessor-blinded randomized controlled trial evaluated a co-designed, 12-week SMS education and support program for parents of children aged 0 to 6 years with early childhood caries attending six public…
Homozygous SCA8 presenting as severe axonal neuropathy without overt cerebellar involvement.
A 35-year-old man with progressive limb weakness beginning at age 15 had severe proximal muscle atrophy and absent deep tendon reflexes, without overt cerebellar signs.
Barriers to Gender-Affirming Care for Nonbinary People: A Systematic-Narrative Hybrid Literature Review.
This systematic-narrative hybrid literature review synthesised qualitative, quantitative and mixed-methods research, alongside systematic and scoping reviews, on barriers to gender-affirming care for nonbinary people.
Multikinase Inhibition with Tinengotinib in Advanced Solid Tumors: Results from a Multicenter Phase Ib/II Trial.
This multicenter phase Ib/II trial evaluated tinengotinib’s safety, pharmacokinetics, antitumor activity, and genomic correlates in patients with advanced or metastatic solid tumors lacking standard treatment options.
Pharmacological treatment of bereavement-related distress: a systematic review.
This systematic review assessed pharmacological treatments for bereavement-related psychological distress, including depression following bereavement.
Generative Artificial Intelligence and Maternal Health Outcomes in Pregnant and Postpartum Individuals: A Randomized Clinical Trial.
This 2-group randomized clinical trial assessed whether a generative AI maternal health chatbot improved outcomes among 400 pregnant or postpartum participants from racial and ethnic minoritized groups recruited across…
Effects of extremely low-volume high-intensity interval training combined with iron supplementation versus iron supplementation alone on postural control in young women with iron deficiency anemia: a randomized controlled trial.
This randomized controlled trial compared 8 weeks of extremely low-volume, plyometric-based high-intensity interval training (HIIT) plus oral iron with iron supplementation alone in young women aged 18–25 years with…
A Comparative Study of the Efficacy and Safety of Two Misoprostol Regimens for Labour Induction at Term in Delta State: A Two-centre Triple-blind Randomised Controlled Trial.
This two-centre, triple-blind randomised controlled trial compared hourly titrated oral misoprostol with four-hourly 25 mcg vaginal misoprostol for labour induction in 260 singleton term pregnancies in Delta State…
Breast Adenomyoepithelioma with Malignant Changes in a 36-year-old Female: Clinicopathological, Histomorphological and Therapeutic Considerations.
A woman described in the abstract as 360 years old presented with an asymptomatic left breast tumour measuring 2.5 cm × 2.0 cm × 0.8 cm.
Wernicke's encephalopathy secondary to hyperemesis gravidarum in pregnancy.
A 28-year-old woman at 17 weeks’ gestation presented with severe hyperemesis gravidarum and cerebellar dysfunction. She met three of the four European Federation of Neurological Societies diagnostic requirements for…
Safety and Efficacy of Intratumoral MEDI1191, an IL12 mRNA Lipid Nanoparticle, plus Intravenous Durvalumab in Patients with Advanced Solid Tumors: A First-in-Human Study.
This open-label, multicenter, first-in-human phase I dose-escalation study evaluated intratumoral MEDI1191, an IL-12 mRNA lipid nanoparticle, with intravenous durvalumab in adults with advanced or metastatic solid…
Optimizing the Therapeutic Index: Sequential Intraarterial-Intravenous PRRT with Personalized Volumetric-Adjusted Dosing.
This prospective clinical trial assessed a personalized sequence of intraarterial then intravenous 177Lu-DOTATATE in 10 adults with progressive, nonresectable, liver-dominant metastatic gastroenteropancreatic…
Selective Electrical Muscle Stimulation of the Vastus Medialis in a Patient With Knee Osteoarthritis, With Changes in Muscle Quality, Symptoms, and Physical Activity: A Case Report.
A 77-year-old man with Kellgren-Lawrence grade 2 right knee osteoarthritis had stopped regular exercise, including aquatic walking, because of knee pain.
Sphenoidal Meningioma with Focal Seizures Masquerading as Immune Reconstitution Inflammatory Syndrome in HIV Patient.
A 47-year-old woman with HIV developed recurrent focal-onset seizures progressing to bilateral tonic-clonic seizures about 4 weeks after starting antiretroviral therapy.
Changes in Alcohol Use among Adults with Cancer Participating in the ECOG-ACRIN EAQ171CD Tobacco Treatment Trial.
This post hoc analysis of the randomized ECOG-ACRIN EAQ171CD tobacco-treatment trial examined alcohol-risk changes among 305 adults with cancer who smoked, comparing virtual sustained treatment (VST) with enhanced usual…
Danvatirsen plus Pembrolizumab versus Pembrolizumab for Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma (PEMDA-HN): A Randomized, Phase II Trial.
PEMDA-HN was a multicenter, open-label, randomized phase II trial comparing first-line danvatirsen plus pembrolizumab with pembrolizumab alone in patients with previously untreated, PD-L1-positive recurrent or…
The Effect of Perioperative Video Interventions on Postoperative Pain Control: A Systematic Review.
This systematic review examined randomized controlled trials of perioperative video interventions in adult surgical patients, assessing postoperative pain intensity and analgesic consumption.
Comparison of the opioid-sparing effects of a combination of dexamethasone, paracetamol, and ketorolac versus paracetamol and ketorolac in patients undergoing total laparoscopic hysterectomy: A prospective double-blind randomized controlled trial.
This prospective, double-blind randomized controlled trial compared adding intravenous dexamethasone to paracetamol and ketorolac with paracetamol and ketorolac alone in 100 women aged 18–60 years with ASA I–II status…
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