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2000 articles
October 202624
Efficacy and safety study of diclofenac epolamine topical patch in accelerating rehabilitation of moderate hamstring strain: A randomized controlled trial .
This single-centre, double-blind, placebo-controlled randomised trial evaluated topical diclofenac epolamine alongside rehabilitation in 120 patients with moderate hamstring strain.
From Bench to Bedside: Evaluating the Accuracy of Clinical Sensory Testing in Detecting Somatosensory Disorders. A Systematic Review.
This systematic review assessed the diagnostic accuracy of clinical sensory tests (CSTs) for somatosensory disorders across populations and conditions, comparing test results with reference standards.
Outdoor risky play and health-related outcomes in children aged 3-12 years: A mixed-methods systematic review.
This mixed-methods systematic review synthesised evidence on outdoor risky play and health outcomes in children aged 3–12 years. It included 74 studies: 48 quantitative, 19 qualitative and 7 mixed-methods.
Clinical Pathway Management for Platelet-Rich Plasma Therapy in Kellgren-Lawrence Grade I and II Knee Osteoarthritis: A Prospective, Multicenter, Double-Blind Randomized Controlled Trial.
This multicenter, double-blind randomized controlled trial compared a standardized platelet-rich plasma (PRP) pathway with physician-directed conventional PRP care in patients with Kellgren-Lawrence grade I or II knee…
Multicentric reticulohistiocytosis in children: two case reports and a literature review.
The report describes two boys with multicentric reticulohistiocytosis (MRH), a disorder uncommon in children and liable to be mistaken for juvenile idiopathic arthritis.
Steroid-associated hypofibrinogenemia: an overlooked risk in graft-versus-host disease management after allogeneic hematopoietic stem cell transplantation.
A 47-year-old woman with acute myeloid leukemia developed late acute gastrointestinal graft-versus-host disease after allogeneic hematopoietic stem cell transplantation and received methylprednisolone at 1 mg/kg/day.
Low-dose ketamine modulates brain entropy in treatment-resistant depression: Results from two neuroimaging clinical trials.
This analysis of resting-state functional MRI data from two randomized clinical trials examined whether low-dose ketamine changes brain entropy in patients with treatment-resistant depression.
The combination of simethicone and N-acetylcysteine in lidocaine ice popsicle compared with lidocaine ice popsicle alone in patients undergoing unsedated esophagogastroduodenoscopy: A prospective double-blind randomized controlled trial.
This single-centre, prospective, double-blind randomised controlled trial compared a lidocaine ice popsicle containing simethicone and N-acetylcysteine (NAC) with a conventional lidocaine popsicle in 374 adults…
Ruzaltatug rezetecan versus chemotherapy for EGFR-mutated advanced non-small-cell lung cancer progressing after EGFR tyrosine kinase inhibitor therapy (HERON-Lung01): interim analysis of a randomised, open-label, phase 3 trial in China.
HERON-Lung01 was a randomised, open-label, phase 3 trial at 62 sites in China comparing the HER3-directed antibody-drug conjugate ruzaltatug rezetecan with platinum-pemetrexed chemotherapy in patients with EGFR-mutated…
Association of Screen Time With Physical and Mental Health in University Students: Systematic Review and Meta-Analysis.
This systematic review and meta-analysis examined screen-time duration and physical and mental health outcomes in university students aged 17 years or older.
Evaluating gain and loss-framed mobile messaging to improve maternal health service uptake: A cluster randomized controlled trial in Jimma, Ethiopia.
This three-arm cluster-randomized controlled trial assessed whether gain- or loss-framed SMS messaging improved maternal health service use among 588 pregnant women in Jimma Zone, Ethiopia.
Effectiveness of Exercise Snacks in Mitigating Adolescent Problematic Smartphone Use: A Four-Wave Cluster Randomized Controlled Trial.
This four-wave cluster randomized controlled trial tested whether brief, vigorous activity breaks could reduce problematic smartphone use among 386 adolescents in 12 secondary-school classes.
Safety and Effectiveness of a Novel Laser-Based Intravascular Lithotripsy System for Coronary Calcium: FRACTURE Study.
FRACTURE was a prospective, multicenter, single-arm clinical trial evaluating a laser- and optic-based quad-emitter intravascular lithotripsy system in patients with severely calcified de novo coronary lesions.
Safety of low lipoprotein(a) levels: the FOURIER trial.
This analysis of the randomized, multicentre FOURIER trial examined associations between lipoprotein(a) [Lp(a)] levels and safety outcomes in patients with stable atherosclerotic cardiovascular disease receiving…
Fertility Treatment and Risk of Melanoma: A Certainty-Rated Systematic Review and Meta-Analysis of 3,733,499 Women.
This certainty-rated systematic review and random-effects meta-analysis examined observational evidence on fertility treatment and incident melanoma in women.
Dyspnea Reduction With L-Menthol Inhalation Improves High-Intensity Endurance Running Performance in Healthy Trained Adults.
This randomized, counterbalanced crossover trial tested whether L-menthol inhalation reduces breathlessness and improves high-intensity running performance in 18 trained endurance runners with normal spirometry.
An Individual Meta-Analysis of Psychological Treatments for Mood and Personality Disorders Using the Severity Diagnostic System of ICD-11.
This individual patient meta-analysis examined whether ICD-11 personality-disorder severity was associated with short-term outcomes in 1,384 patients from four randomised trials of psychological treatments, mainly…
Local Delivery of Interferon-β1a for Respiratory Viral Infections: A Systematic Review.
This PRISMA-guided systematic review assessed locally delivered intranasal or inhaled interferon-β1a for respiratory viral infections, covering clinical trials and experimental evidence.
Consequences of opioid exposure in disease-free cancer survivors: A systematic literature review.
This systematic literature review examined the consequences of persistent opioid exposure after curative-intent treatment in disease-free cancer survivors.
Berberine improves diabetic foot ulcer healing after tibial transverse osteotomy by inhibiting the PDGF-B/PDGFRβ signaling pathway .
This prospective, single-centre, randomized, placebo-controlled trial evaluated local berberine injections added to tibial transverse osteotomy (TTO) in patients with Wagner grade 2–4 diabetic foot ulcers.
A Short Evidence-Based, Belief-Focused Educational Video Improves Back Pain Beliefs but Not Lifting Behaviour in Healthy Office Workers: An Exploratory Randomised Controlled Trial.
This assessor-blind exploratory randomised controlled trial assigned 50 healthy office workers to a brief video about back pain beliefs and management or an anatomy-video control.
A systematic review of the spectrum of magnetic resonance imaging features of degenerative thoracic myelopathy.
This PRISMA-guided systematic review synthesised evidence on MRI features of degenerative thoracic myelopathy (DTM) and their clinical significance.
The association between e-cigarette use and dyslipidemia: A systematic review and meta-analysis of observational studies.
This systematic review and meta-analysis examined observational evidence on exclusive e-cigarette use and blood lipids in adults. Seven studies from four countries included 25,690 participants.
Impact of age and frailty on the effect of a multimodal individualized long-term intervention after stroke: the last-long trial.
This single-blinded, multicentre randomized controlled trial examined whether age or frailty modified response to a stroke coordinator-led, individualized community intervention.
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