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2000 articles
October 202624
Atypical Fibroxanthoma Presenting as a Rapidly Enlarging Tender Papule: Case Report.
A 67-year-old woman with prior basal and squamous cell carcinomas presented with a rapidly enlarging, tender papule on the dorsal left hand that had not responded to topical 5-fluorouracil.
Prevalence of fall risk and fear of falling among older adults in the Middle East and North Africa: a systematic review and meta-analysis.
This systematic review and random-effects meta-analysis estimated fall risk and fear of falling among adults aged 60 years or older in the Middle East and North Africa (MENA).
Decitabine plus busulfan-cyclophosphamide versus busulfan-cyclophosphamide myeloablative conditioning before allogeneic haematopoietic stem cell transplantation for reducing risk of relapse in adult KMT2A‑rearranged leukaemia in China: an open-label, multicentre, randomised phase 3 trial.
This open-label, multicentre, randomised phase 3 trial compared decitabine plus busulfan-cyclophosphamide (DAC-BuCy) with BuCy conditioning before allogeneic HSCT in 130 patients aged 14–65 years with KMT2A-rearranged…
The effect of propolis oral care on oral mucositis in intensive care patients with chronic obstructive pulmonary disease: a randomized controlled trial.
This randomized controlled trial evaluated whether adding propolis gargle to standard oral care prevented oral mucositis in 60 critically ill patients with chronic obstructive pulmonary disease.
The paracondylar process: anatomical relationships and clinical implications.
A 55-year-old man with longstanding restricted neck movement, left-sided headaches and occasional dizziness underwent cervical CT.
Lurasidone Induced Amphibian Like Buccal Oscillations: A Rare Case of Early Onset Tardive Dyskinesia Like Disorder in a Geriatric Patient with Treatment-Resistant Depression.
A 64-year-old woman with treatment-resistant depression developed floor-of-mouth movements resembling buccal pumping, along with white spots on the inner lower lip and facial puffiness, within 7 days of starting…
Digital Health Services and Healthcare Management Outcomes: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed digital health services—including telemedicine, telemonitoring, virtual consultations, and remote care—against conventional care across 21 eligible studies.
Artificial Intelligence-Enabled Electrocardiogram Screening for Detection of Low Ejection Fraction in Routine Care: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
This systematic review and meta-analysis evaluated randomised controlled trials of AI-enabled ECG screening for low ejection fraction in adults without known heart failure undergoing routine ECGs.
Effects of psilocybin with psychological support on anhedonia in treatment-resistant depression: A randomized controlled pilot trial.
This randomized, double-blind, placebo-controlled pilot trial assessed psilocybin with psychological support for anhedonia in 20 participants with treatment-resistant major depressive disorder.
Dose-Dependent Effect of Crocin on Depressive and Anxiety Symptom Scores: A GRADE-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials.
This GRADE-assessed systematic review and meta-analysis examined dose-response associations between crocin supplementation and depressive and anxiety symptom scores in 14 randomized controlled trials.
Integrated Traditional Chinese Medicine, Mili-Fire Needle, and Light-Emitting Diode Phototherapy for Cystic Acne and Post-Acne Sequelae.
This single-center, parallel-group randomized clinical study compared an integrated traditional Chinese medicine regimen, mili-fire needle therapy, and red-blue LED phototherapy with isotretinoin plus the same…
Heterogeneity in Depression and Suicidality Risk Among Vitiligo Patients: A Meta-Analysis of Adolescent Complexity and Subgroup Stratification.
This meta-analysis assessed depression and suicidality in people with vitiligo, drawing on 73 studies identified through searches of four databases. The pooled prevalence of depression was 0.37 (95% CI, 0.30-0.45).
Auricular point acupressure for chemotherapy-induced peripheral neuropathy: a randomized controlled trial.
This pragmatic randomized controlled trial evaluated auricular point acupressure (APA) for chemotherapy-induced peripheral neuropathy in 227 cancer survivors, comparing in-person delivery, video-guided self-placement…
Sexual dimorphism and age effects in CKD and type 2 diabetes in the CONFIDENCE trial.
This analysis of the randomized CONFIDENCE trial examined age- and sex-related differences in urinary albumin-to-creatinine ratio (UACR) changes among people with type 2 diabetes and chronic kidney disease receiving…
Prone positioning and high-frequency oscillatory ventilation in early paediatric acute respiratory distress syndrome (PROSpect): an international, two-by-two factorial, response-adaptive, phase 3, randomised controlled trial.
PROSpect was an international, two-by-two factorial, phase 3 randomised controlled trial comparing prone with supine positioning and high-frequency oscillatory ventilation (HFOV) with conventional mechanical ventilation…
First-in-Human Phase 1b/2a Trial Shows Safety with MEK 1/2 Inhibitor EDV2209 as A Novel Treatment for Spontaneous Subarachnoid Hemorrhage.
The STOP-DCI first-in-human Phase 1b/2a interventional, randomized, double-blind, placebo-controlled trial evaluated intracerebroventricular EDV2209, a MEK 1/2 inhibitor, in patients with severe spontaneous subarachnoid…
First-in-Human Phase 1 Evaluation of the DegradaBALL Mesoporous Silica Nanoparticle Delivery System: An mRNA SARS-CoV-2 Vaccine Study in Healthy Korean Adult Volunteers.
mRNA vaccines require an effective delivery system for intracellular uptake, and alternative carriers with improved stability and tolerability remain of continued interest.
Associated factors for stress ulcers and gastrointestinal bleeding in patients with sepsis or septic shock: A systematic review.
This systematic review synthesized observational cohort and case-control studies of factors associated with stress ulcers or significant gastrointestinal bleeding in adults with sepsis or septic shock.
Nurse-Led treatment strategy based on asthma score and oxygen requirement in children with acute reversible bronchoconstriction: A randomised controlled non-inferiority trial.
This multicentre, open-label, randomised non-inferiority trial compared nurse-led treatment guided by the oxygen-adjusted Childhood Asthma Score (CAS O2) with the standard CAS protocol in children aged 2–18 years…
Treatment Procedures for the Edentulous Maxilla: Supplement Report for the First Global Consensus for Clinical Guidelines (GCCG).
The report describes clinical rehabilitation of an edentulous maxilla using implant-supported restorations. It applies the treatment-procedures component of the First Global Consensus for Clinical Guidelines (GCCG)…
The effect of early rehabilitation nursing on the recovery of cardiac function in patients with acute myocardial infarction.
This prospective randomised controlled trial compared structured early rehabilitation nursing with routine postoperative nursing in patients with acute myocardial infarction treated by percutaneous coronary…
Community health worker intervention to prevent incident type 2 diabetes: A cluster randomized trial.
This pragmatic cluster-randomized controlled trial tested whether a 12-month community health worker (CHW) program could prevent type 2 diabetes in adults aged 18–75 years with prediabetes receiving care at two New York…
Effects of a music-accompanied multimodal exercise program on trunk endurance, stress, and anxiety in university students: a randomized controlled trial.
This randomized controlled trial evaluated a 12-week, music-accompanied program combining core stabilization, diaphragmatic breathing, and relaxation in 80 university students assigned to intervention or waitlist…
Effects of a telehealth-supported home-based exercise program on functional capacity, sarcopenia risk, and patient-reported outcomes in non-dialysis stage 4-5 chronic kidney disease.
This prospective, parallel-group randomized controlled trial assessed a 12-week telehealth-supported home exercise program in adults aged ≥45 years with non-dialysis stage 4-5 chronic kidney disease.
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