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2000 articles
November 202624
Clinical Reasoning: A 33-Year-Old Man With Rapidly Progressive Ataxia.
A 33-year-old man with AIDS developed subacute progressive confusion, blurred vision, diplopia, and generalized cerebellar ataxia after hospitalizations for opportunistic infections.
Clinical Reasoning: A 69-Year-Old Female Patient With Rapid-Onset Levodopa-Responsive Rest Tremor, Parkinsonism, and Gait Freezing.
A 69-year-old woman developed a unilateral resting tremor that rapidly spread to the opposite arm and then the legs. Within 3 months, she had generalized parkinsonism, a shuffling gait with prominent freezing, and…
Prosthesis-Patient Mismatch and Patient-Centered Outcomes After TAVR.
This post hoc analysis of the multicentre SCOPE I randomised trial examined whether prosthesis-patient mismatch (PPM) severity after transcatheter aortic valve replacement was associated with survival and…
Multifocal intradural extramedullary myxopapillary ependymoma of the spine.
A 34-year-old man presented with sudden severe non-radicular low-back pain but no neurological deficit. MRI showed multiple enhancing intradural extramedullary lesions from T12-L1 to S1; the dominant T12-L1 lesion…
Evening amber-lensed glasses in combination with a prescribed wake time advance circadian timing in adolescents with delayed sleep-wake phase disorder.
This 3-week randomized controlled trial tested evening amber-lensed glasses plus a prescribed stable wake time in adolescents aged 14.3–18.1 years with delayed sleep-wake phase disorder (DSWPD).
Sequencing trastuzumab deruxtecan and sacituzumab govitecan in metastatic breast cancer: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed whether treatment order affects outcomes when patients with metastatic breast cancer receive both trastuzumab deruxtecan (T-DXd) and sacituzumab govitecan (SG).
The pen-and-paper tube figures mental rotation task for patients with trauma-related disorders: a randomized controlled trial.
This single-centre, single-blind randomized controlled trial compared a one-session pen-and-paper Tube figures imagery-competing task intervention with a Wikipedia control in 40 patients with trauma-related disorders.
Barriers and facilitators to HPV vaccination among adult men: A systematic review and qualitative meta-synthesis.
This qualitative systematic review and meta-synthesis examined barriers and facilitators to HPV vaccination among adult men and how healthcare services address vaccination needs.
Surgical outcomes and functional morbidity after retrosigmoid/retrocondylar and midline suboccipital approaches for foramen magnum meningiomas: a single-arm meta-analysis.
This PRISMA-guided systematic review and single-arm meta-analysis assessed surgical control and functional morbidity after posterior or posterolateral approaches for foramen magnum meningiomas.
Prevalence and Consequences of Guideline-Directed Indications for Aortic Valve Replacement in the EARLY TAVR Trial.
This analysis of the multicenter randomized EARLY TAVR trial examined how often patients with asymptomatic severe aortic stenosis had ACC/AHA Class II indications for aortic valve replacement (AVR), and whether these…
Cognitive Behavioural Therapy to Optimize Post-Operative Fracture Recovery (COPE): a randomized controlled trial.
This multicentre randomized controlled trial tested whether app-based cognitive behavioural therapy (CBT) reduced persistent postsurgical pain in adults with operatively treated extremity fractures at 11 hospitals in…
Machine Learning Models for Glycemic Prediction in Type 1 and Type 2 Diabetes: Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed machine-learning models predicting glucose values or glycemic events in people with type 1, type 2, mixed, or unclear diabetes.
Multiorgan [ 18 F]florbetapir PET/CT uptake in multiple myeloma-associated systemic AL amyloidosis: a case report.
A 77-year-old man with multiple myeloma underwent whole-body [18F]florbetapir PET/CT because AL amyloidosis was suspected. The scan showed prominent tracer retention in the myocardium, thyroid, lungs, parotid glands…
Short-term outcomes of the hinotori versus da Vinci robotic surgical systems in colorectal cancer surgery: a systematic review and meta-analysis.
This systematic review and meta-analysis compared short-term perioperative outcomes of hinotori and da Vinci robotic systems in colorectal cancer surgery.
Prolonged exposure, eye movement desensitization and reprocessing therapy, and cognitive restructuring versus waiting-list for individuals with PTSD and psychosis (RE.PROCESS): A multicenter, four-arm, assessor-masked, superiority randomized controlled trial.
The multicenter, assessor-masked RE.PROCESS randomized controlled trial compared Prolonged Exposure (PE), eye movement desensitization and reprocessing (EMDR), and Cognitive Restructuring (CR), each alongside usual…
Sex Differences in Blood Pressure Dynamics and Outcomes After Endovascular Thrombectomy.
This exploratory secondary analysis of the multicenter, open-label, blinded-end-point ENCHANTED2/MT randomized trial examined sex differences in blood pressure (BP) and outcomes among adults with acute ischemic stroke…
Cardiac Damage and Clinical Outcomes in Symptomatic Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement.
This post hoc subanalysis of the multicentre, randomised LANDMARK trial examined whether updated echocardiographic cardiac-damage stages stratified outcomes after transcatheter aortic valve replacement (TAVR) in…
Efficacy and safety of the cladribine, idarubicin, and cytarabine regimen for treating acute myeloid leukemia: a systematic review and single-arm meta-analysis.
This systematic review and single-arm meta-analysis assessed the efficacy and safety of cladribine, idarubicin, and cytarabine (CIA) for acute myeloid leukemia (AML), separating newly diagnosed (ND) from…
The characteristics of men who have sex with men presenting with oral syphilis: a systematic review.
This systematic review described demographic, behavioural, co-infection and clinical features of men who have sex with men (MSM) presenting with oral syphilis.
Intractable Nausea and Vomiting: A Key Feature of Neuromyelitis Optica Spectrum Disorder.
A 22-year-old woman had five weeks of intractable nausea, vomiting, and hiccups. Delayed gastric emptying led to an initial diagnosis of gastroparesis, but symptoms persisted despite antiemetic and prokinetic therapy.
Impact of artificial intelligence-assisted health management on blood pressure and self-management efficacy in older adults with hypertension.
This randomized controlled trial compared AI-assisted health management with routine care in older adults with hypertension. The intervention included intelligent monitoring, early warning and proactive intervention.
Dose-dense neoadjuvant bi-weekly nab-paclitaxel followed by epirubicin-cyclophosphamide versus bi-weekly docetaxel followed by epirubicin-cyclophosphamide in patients with HR+/HER2- early breast cancer: a multicentre, randomised, phase III trial.
This multicentre, randomised phase III trial at three hospitals in China compared dose-dense neoadjuvant nab-paclitaxel with docetaxel, each followed by epirubicin-cyclophosphamide, in patients with early HR+/HER2−…
Single-port robotic thoracic surgery: a systematic review and meta-analysis of comparative outcomes versus multiport robotic surgery and uniportal VATS.
This systematic review and meta-analysis compared single-port robotic-assisted thoracic surgery (SP-RATS) with multiport robotic surgery (MP-RATS) and uniportal video-assisted thoracoscopic surgery (uVATS).
Pearls & Oy-sters: Anti-GABA A Receptor Encephalitis Presenting as Fulminant Hemicerebellitis in a 5-Year-Old Girl.
A previously healthy 5-year-old girl developed acute neurologic decline after several days of fever and malaise. CT showed severe right cerebellar inflammation and edema with fourth-ventricle effacement, prompting…
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