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2000 articles
October 202624
Pseudodominant inheritance in paraplegin (SPG7)-associated CPEO-ataxia syndrome.
A 47-year-old man presented with progressive external ophthalmoplegia, ptosis, gait disturbance and spasticity. Over ten years, he developed slowly progressive spastic ataxia with ocular motor involvement and neurogenic…
Impact of Intermittent Preventive Treatment for Malaria in Pregnancy With Sulfadoxine-Pyrimethamine, Dihydroartemisinin-Piperaquine, and Their Combination on Infant Outcomes: A Randomized Controlled Trial.
This double-blind randomized controlled trial compared infant malaria and growth outcomes after maternal intermittent preventive treatment in pregnancy with sulfadoxine-pyrimethamine (SP), dihydroartemisinin-piperaquine…
A NETwork meta-analysis with COST-effectiveness evaluation of pharmacological treatments for heart failure with reduced ejection fraction: NET-COST-HFrEF.
This network meta-analysis of 47 randomized controlled trials involving 75,978 patients with heart failure with reduced ejection fraction assessed guideline-directed drug combinations and their cost-effectiveness.
Long-term impact of aficamten on patient-reported outcome measures in obstructive hypertrophic cardiomyopathy: results from FOREST-HCM.
This open-label extension study assessed longer-term patient-reported outcomes with aficamten in people with obstructive hypertrophic cardiomyopathy who had completed an aficamten trial.
Treatment of Crimean-Congo Hemorrhagic Fever With Supportive Care, Favipiravir, and Avatrombopag.
A patient with severe Crimean-Congo hemorrhagic fever was managed in a high-level isolation unit with supportive care, favipiravir, and avatrombopag.
Subgroup Analysis of Pooled Phase 3 Efficacy Data From Two Randomized Trials of Gepotidacin Versus Nitrofurantoin in Uncomplicated Urinary Tract Infections (EAGLE-2 and EAGLE-3) Including Participants With Uropathogens Not-Susceptible to Nitrofurantoin.
This pooled subgroup analysis of two phase 3 randomized trials compared gepotidacin with nitrofurantoin in female participants aged ≥12 years with uncomplicated urinary tract infections.
IDIOPATHIC ACUTE EXUDATIVE POLYMORPHOUS VITELLIFORM MACULOPATHY-CASE SERIES AND EXTENDED FEATURES.
Three subjects with idiopathic acute exudative polymorphous vitelliform maculopathy had bilateral localized serous macular detachments that coalesced into yellow-white vitelliform deposits with a hyperautofluorescent…
Immunogenicity and Safety of Coadministration of AS01E-Adjuvanted Respiratory Syncytial Virus Prefusion F Protein Vaccine and a COVID-19 mRNA Vaccine in Adult s Aged ≥50 Years: A Phase 3, Randomized, Noninferiority Trial.
This phase 3, open-label, multicenter randomized noninferiority trial compared coadministration of an AS01E-adjuvanted RSV prefusion F vaccine and an Omicron XBB.1.5 COVID-19 mRNA vaccine with administration…
Treatment of Progressive Multifocal Leukoencephalopathy With Third-Party Allogeneic BK Virus T Cells.
This single-center phase 2 study evaluated third-party, partially HLA-matched BK virus-specific T cells in 37 patients with progressive multifocal leukoencephalopathy (PML), including 23 with hematologic malignancy.
Controlled postoperative red wine intake versus abstinence in habitual wine drinkers undergoing elective urological surgery (WISE): a translational randomized controlled trial assessing quality of life, surgical outcomes and complications.
This single-center randomized controlled trial compared postoperative abstinence with standardized red wine intake in habitual wine drinkers undergoing elective urological surgery.
ACUTE BILATERAL RETINAL AND CHOROIDAL DETACHMENT-A CASE REPORT.
A 57-year-old man developed profound bilateral visual loss while hospitalized with sepsis of unknown cause and was referred three weeks later with bilateral retinal detachment.
Changes in gait function associated with cerebral small vessel disease-related cognitive impairment during dual-task walking: a systematic review and meta-analysis.
This systematic review and meta-analysis examined whether dual-task (DT) gait measures distinguish people with cerebral small vessel disease-related cognitive impairment (CSVD-CI) from cognitively unimpaired controls…
A Randomized, Double-Blind, Placebo-Controlled Study of the PD-1 Inhibitor Cetrelimab in Chronic Hepatitis B.
This randomized, double-blind, placebo-controlled study assessed the safety, activity and pharmacokinetics of a single low dose of the PD-1 inhibitor cetrelimab in adults with chronic hepatitis B virologically…
Effect of photobiomodulation on recovery from oral soft tissue local anaesthesia in paediatric patients: a preliminary split-mouth randomized clinical trial.
This preliminary split-mouth randomized clinical trial assessed whether 810-nm diode laser photobiomodulation (PBM) shortened oral soft-tissue anaesthesia after infiltration local anaesthesia in 34 children aged 8–12…
Comparison of sterile silicone studs and scalp infiltration with lignocaine for the attenuation of the hemodynamic and stress response to skull pin insertion during craniotomy in pediatric neurosurgical patients: a randomized controlled trial : Sterile silicone studs versus lignocaine infiltration for skull pin insertion.
This randomized controlled trial compared sterile silicone studs (SSS) with lignocaine infiltration for skull pin insertion in 64 children aged 12 years or younger undergoing neurosurgery.
Effect of intraoral glossopharyngeal nerve block on hemodynamic response to mouth retractor placement in transoral robotic surgery: a randomized clinical trial.
This prospective, single-centre randomized clinical trial assessed whether bilateral intraoral glossopharyngeal nerve block attenuates the blood-pressure response to mouth retractor placement during transoral robotic…
Robot-assisted versus conventional cranial stereotactic neurosurgery: a systematic review and meta-analysis of targeting accuracy, procedural efficiency, and safety.
This systematic review and meta-analysis compared robot-assisted with conventional cranial stereotactic neurosurgery across 21 comparative studies, examining targeting accuracy, procedural efficiency, safety and…
Non-Traumatic Subperiosteal Orbital Hematoma After Cardiopulmonary Resuscitation: A Case Report.
A 48-year-old woman with end-stage renal disease had a cardiac arrest during hemodialysis and received 24 minutes of CPR, with return of spontaneous circulation.
Short-term effects of myofascial release with therapist-mediated transcutaneous electrical nerve stimulation in adolescent idiopathic scoliosis: an exploratory randomized controlled trial .
This assessor-blinded, exploratory randomized controlled trial evaluated short-term myofascial release with therapist-mediated transcutaneous electrical nerve stimulation (MFR-TENS) in 27 adolescents with idiopathic…
Germline BRCA-Lynch syndrome MINAS: report of six Argentinian families and a systematic review of the literature.
This report combined six Argentinian families with a systematic review of 40 publications to describe the phenotype of BRCA-Lynch syndrome (BRCA-LS) MINAS. The analysis included 92 patients from 69 families.
A Bayesian Re-analysis of the GALFLU Trial of High-Dose vs Standard-Dose Influenza Vaccine Against Hospitalization Outcomes.
This Bayesian re-analysis examined hospitalization outcomes in the GALFLU randomized trial, which compared high-dose with standard-dose inactivated influenza vaccine in adults aged 65–79 years.
Renal vein thrombosis with inferior vena cava extension and pulmonary embolism in a patient with acute pyelonephritis: a case report and updated literature review.
A previously healthy 29-year-old man presented with two weeks of left flank pain and fever. Contrast-enhanced CT showed acute left pyelonephritis and extensive renal vein thrombosis extending into the suprarenal…
A randomised controlled crossover trial comparing two mandibular repositioning appliances for treatment of moderate obstructive sleep apnoea.
This single-centre, randomised two-period crossover trial compared two custom-made mandibular repositioning appliances in 16 adults with moderate obstructive sleep apnoea.
Peritoneal Tuberculosis and Chronic Myeloid Leukaemia: A Case of Hickam's Dictum.
A 34-year-old man presented with persistent fever, ascites, thrombocytosis and clinical deterioration despite broad-spectrum therapy.
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