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2000 articles
November 202624
The Role of Stress-Related Biomarkers, Immune-Inflammatory Pathways, and Genetic Polymorphisms in Cognitive-Behavioral Therapies for Chronic Low Back Pain and Depression: Results From a Randomized Controlled Trial (The IMPACT Study).
This randomized controlled trial examined whether Acceptance and Commitment Therapy (ACT) or Behavioral Activation Therapy for Depression (BATD), each added to usual care, affected biomarkers or clinical outcomes in 114…
XR serious games for phantom limb pain, neurofunctional recovery, and prosthetic adoption: a systematic review.
This systematic review synthesized studies of extended-reality serious games for adults with limb amputation, examining phantom limb pain, rehabilitation, embodiment, and prosthesis adoption.
Clinical Reasoning: A 55-Year-Old Woman With a Hyperkinetic Movement Disorder, External Ophthalmoplegia, and Myopathy.
A 55-year-old woman was evaluated for an 8-year history of hyperkinetic movements. Her examination and clinical picture also included mild ataxia, spasticity in the lower limbs, external ophthalmoplegia, and myopathy.
A Superior Spermatic Cord Denervation Technique?: A Meta-Analysis.
This systematic review and meta-analysis compared standard, targeted complex, and robotic-assisted spermatic cord denervation for men with chronic orchialgia.
Effects of Morning Strength and Power Priming Exercises on Afternoon Physical and Cognitive Performance in Male Rugby Union Players.
This randomised, counterbalanced study examined whether morning strength and power exercises affected afternoon physical and cognitive performance in 25 male rugby union players.
Differential effects of pea protein isolate, pea protein concentrate, and whey protein isolate supplementation on gut microbiota and metabolic markers in healthy adults: a 3-arm parallel randomised intervention.
This double-blind, three-arm randomised dietary intervention compared four weeks of pea protein concentrate (PPC), pea protein isolate (PPI), or whey protein isolate (WPI) supplementation in healthy adults.
Perioperative neurocognitive outcomes after robot-assisted pelvic surgery: a systematic review and meta-analysis of reported proportions, comparative risk and prognostic factors.
This systematic review and meta-analysis examined delirium and cognitive decline after robot-assisted pelvic surgery in adults, including reported proportions, comparative risk, and prognostic factors.
Sperm DNA Fragmentation Index, Semen Quality, and Assisted Reproductive Technology Outcomes: A Systematic Review and Meta-analysis of Observational Studies.
This systematic review and meta-analysis of 87 observational studies assessed associations between sperm DNA fragmentation index (DFI), semen parameters, and assisted reproductive technology (ART) outcomes.
Postoperative Tumor-Informed Circulating Tumor DNA Status for Molecular Residual Disease Detection After Curative-Intent Resection of Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis pooled observational evidence on postoperative tumor-informed circulating tumor DNA (ctDNA) as a marker of molecular residual disease after curative-intent resection of…
Evaluating the Feasibility, Acceptability, and Preliminary Efficacy of Virtually Delivered Dialectical Behaviour Therapy Skills Groups Among Emerging Adults in India.
This randomized controlled trial assessed the feasibility, acceptability, and preliminary efficacy of an eight-week, video-delivered dialectical behaviour therapy skills group led by student therapists in India.
The Effect of Shoulder Support on Shoulder Subluxation in Stroke Survivors Based on Ultrasonography Findings: A Randomized Clinical Trial.
This single-blind randomized controlled trial assessed whether adding a standardized shoulder support to conventional rehabilitation improved shoulder subluxation, pain, upper-limb motor function, or independence in 40…
The unseen risk: a systematic review of the incidence, management, and outcomes of the trigeminocardiac reflex in skull-base surgery.
This PRISMA-guided systematic review synthesized reports of intraoperative trigeminocardiac reflex (TCR) during skull-base and adjacent neurosurgical procedures.
The Safety, Pharmacokinetics, and Antiviral Activity of ABI-4334, A Novel Next-Generation Hepatitis B Capsid Assembly Modulator.
Two randomized Phase 1 studies assessed ABI-4334, a hepatitis B capsid assembly modulator, in healthy volunteers and participants with chronic hepatitis B (cHBV).
Cutaneous Silent Period-Based Comparison of Dorsal Root Ganglion Pulsed Radiofrequency and Transforaminal Epidural Steroid Injection in Lumbar Radicular Pain: A Randomized Controlled Trial.
This prospective, single-blind randomized controlled trial compared dorsal root ganglion pulsed radiofrequency (DRG-PRF) with transforaminal epidural steroid injection (TFESI) in 36 patients with chronic unilateral…
Socio-economic status, cardiovascular risk factors, and coronary atherosclerosis: a SCOT-HEART trial analysis.
This post-hoc analysis of a multicentre randomised trial examined socioeconomic status (SES) in relation to coronary CT angiography (CCTA) plaque features, management, and cardiovascular outcomes.
Effect of discontinuing antihypertensives on perioperative hypotension in older patients before non-cardiac surgery: multicentre, randomised, double blind, controlled trial.
This multicentre, randomised, double blind, placebo controlled trial assessed whether withholding ACE inhibitors or ARBs on the morning of surgery reduces perioperative hypotension in older adults undergoing non-cardiac…
Is Exercise Effective at Reducing Pain Catastrophizing in People With Chronic Nonspecific Spinal Pain? A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis examined whether exercise reduces pain catastrophizing in people with chronic nonspecific spinal pain.
Digital Health Interventions for Pregnancy- and Childbirth-Related Posttraumatic Stress Disorder Symptoms in Postpartum Women: Systematic Review and Meta-Analysis.
This systematic review and meta-analysis pooled randomized controlled trials of digital health interventions for postpartum women who had experienced pregnancy- or childbirth-related trauma.
Imaging-Based AI for Predicting Pathological Complete Response in Esophageal Cancer After Neoadjuvant Therapy: Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed imaging-based AI models for predicting pathological complete response after neoadjuvant therapy for esophageal cancer, separating internal from external validation.
The Association Between Paternal BMI and Semen Quality in Cohorts Undergoing IUI, IVF and ICSI Fertility Treatments: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis examined associations between paternal BMI and semen quality in cohorts undergoing intrauterine insemination or assisted reproductive technology.
Acute Ethylene Glycol Poisoning Following Accidental Mineral Oil Ingestion With Severe Metabolic Acidosis, Acute Kidney Injury, Respiratory Failure, and Delayed Neurological Sequelae: A Case Report.
A 57-year-old man became dizzy, vomited, and developed altered consciousness progressing to coma after accidentally ingesting mineral oil containing ethylene glycol.
Regimens of vitamin D supplementation for women during pregnancy.
This updated Cochrane systematic review and meta-analysis assessed randomised trials of vitamin D regimens during pregnancy in women without pre-existing conditions or multiple pregnancies.
Effects on Sleep Quality and Bioelectrical Parameters of Cellular Health After Administration of a Plant Protein Supplement Combined with Ashwagandha and Rhodiola: A Randomized Controlled Trial.
This randomized, double-blind, placebo-controlled trial tested 30 days of plant protein combined with ashwagandha and rhodiola in adults aged 35–70 years. Of 100 participants assigned, 61 completed sleep assessments.
Physical Activity in Young Girls With Functional Abdominal Pain Disorders: Findings of a Randomized Controlled Intervention Trial With Dance and Yoga.
This randomized controlled trial assessed daily physical activity and abdominal pain in girls aged 9 to 13 years with functional abdominal pain disorders who participated in an 8-month dance and yoga intervention.
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