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2000 articles
November 202624
Generative Artificial Intelligence and Maternal Health Outcomes in Pregnant and Postpartum Individuals: A Randomized Clinical Trial.
This 2-group randomized clinical trial assessed whether a generative AI maternal health chatbot improved outcomes among 400 pregnant or postpartum participants from racial and ethnic minoritized groups recruited across…
Leptomeningeal carcinomatosis arising from esophageal cancer: a systematic review of the literature.
This systematic review synthesized 31 studies describing 43 patients with leptomeningeal carcinomatosis arising from esophageal cancer.
Neoadjuvant concurrent or sequential anthracycline-containing chemotherapy and HER2-targeted agents for HER2-positive breast cancer: a randomized phase 2 study (METIS).
The randomized phase II METIS trial compared neoadjuvant pegylated liposomal doxorubicin (PLD)-based chemotherapy given concurrently with trastuzumab and pertuzumab against sequential epirubicin/cyclophosphamide-based…
Orthoplastic Limb Salvage Using Transtibial Transport and Free-Flap Reconstruction in Patients With Diabetes-Related Chronic Limb-Threatening Ischemia.
A 56-year-old man with poorly controlled diabetes and severe peripheral arterial disease developed a chronic foot ulcer with toe gangrene despite unsuccessful revascularization, leaving no conventional revascularization…
Prognostic value of Murray law-based quantitative flow ratio after percutaneous coronary intervention.
This prespecified subgroup analysis of the randomised FAVOR III China trial assessed whether post-PCI Murray law-based quantitative flow ratio (μQFR) was associated with long-term outcomes.
Persistent Amotivation After Cannabis-Related Psychosis: Diagnostic Challenges and Clinical Course With Electroconvulsive Therapy: A Case Report.
A 19-year-old man developed auditory hallucinations, persecutory delusions, and agitation associated with cannabis use. Antipsychotic treatment improved the psychosis, but marked amotivation and inactivity persisted…
Oral administration of parenteral S-ketamine in wound care when 'conventional' medication regimens are not sufficient: a case series.
A case series described four patients whose pain during wound care was not adequately controlled by conventional medication regimens.
Safety and Efficacy of Intratumoral MEDI1191, an IL12 mRNA Lipid Nanoparticle, plus Intravenous Durvalumab in Patients with Advanced Solid Tumors: A First-in-Human Study.
This open-label, multicenter, first-in-human phase I dose-escalation study evaluated intratumoral MEDI1191, an IL-12 mRNA lipid nanoparticle, with intravenous durvalumab in adults with advanced or metastatic solid…
A Phase II Trial of Pembrolizumab plus Granulocyte-Macrophage Colony-Stimulating Factor in Advanced Biliary Cancer.
This single-center phase II trial evaluated pembrolizumab plus GM-CSF in 42 patients with advanced biliary cancers previously treated with chemotherapy and without prior immune checkpoint inhibitor therapy.
Phase 1/2 trial of Evomela for autologous transplant in myeloma: schedule optimization and matched comparison with MEL200.
This prospective, randomized phase 1/2 trial evaluated Evomela dose and infusion schedule in 60 patients with newly diagnosed multiple myeloma undergoing autologous stem cell transplantation.
Safety, Biodistribution, and Dosimetry of FAP and Integrin α v β 3 Dual-Targeting Radioligand 177 Lu-DOTA-FAPI-RGD: Preclinical Validation and First-in-Human Study in Patients with Advanced Adenocarcinomas.
This phase I, first-in-human study evaluated the safety, biodistribution, dosimetry, and preliminary efficacy of the dual-targeting radioligand 177Lu-LNC1009 in nine patients with advanced solid tumors and positive…
Caring Contacts and Suicidality Among American Indian and Alaska Native Communities: A Randomized Clinical Trial.
The CARE study was a blinded, two-group randomized clinical trial of 709 American Indian and Alaska Native adults with active suicidality across five communities.
Severe neuropsychiatric manifestations in a 17-year-old male with a 20p13 interstitial deletion encompassing CSNK2A1: a case report.
A 17-year-old male had a de novo interstitial 419 kb deletion at 20p13 encompassing CSNK2A1. His presentation was considered compatible with Okur-Chung neurodevelopmental syndrome, although the deletion was described as…
Role of magnesium as a protective agent in cisplatin-induced nephrotoxicity in head and neck cancer.
This randomized controlled trial evaluated intravenous magnesium sulfate for prevention of cisplatin-induced nephrotoxicity in 100 newly diagnosed patients with head and neck squamous cell carcinoma receiving concurrent…
Adjunctive neodymium-doped yttrium aluminum garnet laser therapy for periodontitis in type 2 diabetes: A randomized controlled trial.
This randomized controlled trial compared conventional nonsurgical periodontal therapy with or without adjunctive neodymium-doped yttrium aluminum garnet laser therapy in 120 patients with periodontitis and type 2…
Microbiota-derived urolithins and cortical thickness in cognitively healthy older adults: a longitudinal MRI analysis of the WAHA trial.
This longitudinal MRI sub-study within the randomized WAHA trial examined whether changes in urinary microbiota-derived urolithins tracked with cortical-thickness changes in cognitively healthy older adults.
EMB-01, an Anti-EGFR/c-MET Bispecific Antibody, in Patients with Heavily Pretreated Metastatic Colorectal Cancer from a Phase Ib/II, Open-Label, Multicenter Study.
This phase Ib/II, open-label, multicenter study evaluated weekly intravenous EMB-01, an EGFR/c-MET bispecific antibody, in patients predominantly with heavily pretreated metastatic colorectal cancer (mCRC).
A Phase I First-Time-in-Human, Open-label Study of Nelistotug Administered to Patients with Advanced Solid Tumors.
This first-in-human, open-label, nonrandomized, multicenter phase I study evaluated nelistotug, an anti-CD96 antibody, alone or with dostarlimab, and in a three-drug combination with dostarlimab and belrestotug in…
Changes in Alcohol Use among Adults with Cancer Participating in the ECOG-ACRIN EAQ171CD Tobacco Treatment Trial.
This post hoc analysis of the randomized ECOG-ACRIN EAQ171CD tobacco-treatment trial examined alcohol-risk changes among 305 adults with cancer who smoked, comparing virtual sustained treatment (VST) with enhanced usual…
Conservative Management of Presumptive Free Flap Pedicle Compromise on Postoperative Day 6: Report of Two Cases and Literature Review.
Two patients underwent lower-extremity free-flap reconstruction for exposed tibial bone or hardware. On postoperative day 6, both developed loss of Doppler signal and clinical ischemia, raising concern for late pedicle…
Fascial Patch Reconstruction of a Gastric Conduit Defect Using an Anterolateral Thigh-Vastus Lateralis Composite Free Flap: A Case Report.
A 71-year-old man with a retrosternal gastric conduit developed a full-thickness rupture during coronary artery bypass grafting through median sternotomy.
Expanding the role of ivabradine in thyrotoxic crisis: a case report and Insights from the Literature.
A 39-year-old woman with alemtuzumab-induced Graves’ disease developed thyroid storm with persistent sinus tachycardia despite high-dose propranolol.
Tirzepatide-associated severe euvolemic hyponatremia with syndrome of inappropriate antidiuretic hormone secretion-compatible biochemical features.
A woman with type 2 diabetes and morbid obesity, taking regular insulin and chronic torsemide, developed anorexia, weakness, and drowsiness 10 days after receiving tirzepatide.
Wernicke's encephalopathy secondary to hyperemesis gravidarum in pregnancy.
A 28-year-old woman at 17 weeks’ gestation presented with severe hyperemesis gravidarum and cerebellar dysfunction. She met three of the four European Federation of Neurological Societies diagnostic requirements for…
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