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2000 articles
November 202624
Addition of probenecid to beta-lactam antibiotics in the treatment of skin and soft tissue infections: a systematic review.
This systematic review assessed the effectiveness and safety of adding probenecid to beta-lactam antibiotics for skin and soft tissue infections (SSTIs).
Short communication: Urinary schistosomiasis mimicking a bladder tumour in a Somali student diagnosed in Türkiye.
A 20-year-old Somali student living in Türkiye presented with painless visible haematuria and lower urinary tract symptoms. He had a history of freshwater exposure in Somalia.
Radiomics performance to identify high-risk carotid artery plaques: a systematic review.
This systematic review assessed radiomics-based models for identifying high-risk carotid plaques. It included 28 studies involving 6,108 patients, 72.4% of whom were male.
Sex difference in survival benefits of immune checkpoint inhibitors in advanced non-small cell lung cancer: A meta-analysis.
This random-effects meta-analysis examined sex-stratified survival outcomes from 42 phase 3 randomised trials comparing immune checkpoint inhibitors (ICIs) with chemotherapy in advanced non-small cell lung cancer.
Comparative Effectiveness of Non-Pharmacological Interventions for Management of Post-Orthodontic Pain: A Systematic Review and Network Meta-Analysis.
This systematic review and Bayesian network meta-analysis compared nine non-pharmacological approaches for orthodontic pain after fixed-appliance activation.
Robotic-assisted total knee arthroplasty demonstrates superior early functional outcomes compared with conventional total knee arthroplasty: a quasi-randomised controlled trial.
This quasi-randomised controlled trial compared 1-year outcomes after primary total knee arthroplasty (TKA) in 845 patients treated with robotic-assisted or conventional workflows at one institution.
"Fatal venous thromboembolism and divergent phenotypes in DOCK8 deficiency: a three-sibling case series".
Three siblings with genetically confirmed DOCK8 deficiency had early-onset atopic dermatitis, recurrent respiratory infections, and failure to thrive. All developed bronchiectasis and severe viral infections.
Barriers to Gender-Affirming Care for Nonbinary People: A Systematic-Narrative Hybrid Literature Review.
This systematic-narrative hybrid literature review synthesised qualitative, quantitative and mixed-methods research, alongside systematic and scoping reviews, on barriers to gender-affirming care for nonbinary people.
Chronic erythema nodosum leprosum in Hansen's disease: a challenging clinical management.
A 34-year-old Moroccan man with multibacillary Hansen’s disease developed chronic erythema nodosum leprosum (ENL), with recurrent systemic and cutaneous flares requiring prolonged immunomodulatory treatment.
Treatment of Small Peri-Implant Buccal Dehiscence Defects With SCTG or GBR: 3-Year Results of a Pilot Study.
This pilot randomized controlled trial compared subepithelial connective tissue grafting (SCTG) with guided bone regeneration (GBR) for small (≤ 3 mm) buccal bone dehiscences after single implant placement.
Cost-Effectiveness of Remote Symptom Monitoring During Adjuvant Endocrine Therapy in Breast Cancer.
This economic evaluation used data from a randomized trial of adult women initiating adjuvant endocrine therapy for early-stage breast cancer, comparing remote symptom monitoring via an app, an app with tailored…
Tetracaine hydrochloride gel delays and reduces catheter-related bladder discomfort after transurethral resection: a randomized controlled trial.
This randomized, single-blind trial compared tetracaine hydrochloride gel with standard lubricant in 130 patients undergoing transurethral resection.
A Scalable Teacher Professional Development and Wellness Program in Primary Schools: A Cluster Randomized Clinical Trial.
This cluster randomized clinical trial evaluated professional development (PD), with or without a teacher-wellness enhancement (PDT), in 47 urban and rural primary schools in Uganda.
Extended Follow-up of Botensilimab plus Balstilimab in an Expanded Cohort of Microsatellite-Stable Metastatic Colorectal Cancer without Active Liver Metastases.
This phase Ib clinical trial evaluated botensilimab plus balstilimab in patients with previously treated microsatellite-stable metastatic colorectal cancer without active liver metastases.
The risk of rhegmatogenous retinal detachment associated with topical pilocarpine: a systematic review.
This systematic review assessed whether topical pilocarpine is associated with rhegmatogenous retinal detachment (RRD) in patients aged 40 years or older, synthesising 10 comparative studies.
Effects of bystander interventions on school bullying: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed school-based bystander interventions for bullying and cyberbullying among children and adolescents, drawing on 23 experimental and quasi-experimental controlled studies.
Dual Inhibition of LAG-3 and PD-1 with IBI110 and Sintilimab in Advanced Alveolar Soft Part Sarcoma: A Single-Center, Phase II Trial.
This open-label, single-center phase II trial evaluated IBI110 plus sintilimab in 28 patients with advanced alveolar soft part sarcoma (ASPS), including patients who were naïve or resistant to prior immune checkpoint…
Selective Electrical Muscle Stimulation of the Vastus Medialis in a Patient With Knee Osteoarthritis, With Changes in Muscle Quality, Symptoms, and Physical Activity: A Case Report.
A 77-year-old man with Kellgren-Lawrence grade 2 right knee osteoarthritis had stopped regular exercise, including aquatic walking, because of knee pain.
Germline Genetic Variants and Epilepsy Surgery Response: Individual Participant Pooled Analysis of 272 Patients.
This systematic review and individual-participant pooled analysis examined seizure outcomes after resection or laser ablation in 272 people with pathogenic or likely pathogenic germline epilepsy variants, excluding…
Clinical Reasoning: An 18-Year-Old Woman With Episodic Stiffness, Exercise Intolerance, and Weakness: Decoding a Neuromuscular Mystery.
An 18-year-old woman had longstanding episodic muscle stiffness, cold sensitivity, exercise intolerance, and stable proximal weakness.
Tuberculous meningoencephalitis in a heart transplant recipient: a case report.
A 33-year-old heart transplant recipient receiving immunosuppression developed headache, fever, and focal neurological signs after a complicated admission that included an incidental miliary pulmonary pattern on chest…
Metaplastic Carcinoma of the Breast: A Rare Biphasic Tumour-case Report and Literature Review.
A 49-year-old woman presented with a chronic right breast lump that enlarged rapidly over 3 months, with weight loss and fever. Examination found a large, firm mass and ipsilateral axillary lymphadenopathy.
Effects of Vitamin D 3 Supplementation on Glycaemic Parameters and Insulin Sensitivity in Pre-diabetic Adults: A Prospective Controlled Interventional Study.
This prospective controlled interventional study assessed daily oral vitamin D3 alongside lifestyle advice in 90 pre-diabetic adults aged 18–65 years in Chennai, compared with lifestyle advice alone.
Autologous Blood Pleurodesis for Postoperative Air Leakage Following Video-Assisted Thoracoscopic Surgery-A Randomized Controlled Trial.
This multicentre randomised controlled trial assessed early autologous blood pleurodesis (ABP) for postoperative air leakage after elective video-assisted thoracoscopic surgery.
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