The relationship between sirtuin1 gene polymorphism and coronary heart disease: Systematic review and meta-analysis.
Xin-Yue Xing, Jing Gong, Xiao-Ying Song et al.
✦ AI-curated · Sources linked
In 30 seconds
This systematic review and meta-analysis examined associations between four SIRT1 gene polymorphisms and coronary heart disease (CHD), drawing on 9 articles with 1,839 cases and 1,937 controls. The rs7069102 dominant model (CC + CG > GG) was associated with lower CHD odds (odds ratio = 0.278, 95% confidence interval (0.126-0.612), P = .001), and this association remained significant after multiple-testing correction (adjusted q = 0.013). The rs4746720 dominant-model association was nominal and did not remain significant after correction; the other reported polymorphism comparisons were not associated with CHD risk.
Key findings
- For rs7069102, the dominant model (CC + CG > GG) was associated with lower CHD odds: odds ratio = 0.278, 95% confidence interval (0.126-0.612), P = .001; adjusted q = 0.013.
- The rs4746720 dominant model (TC + TT > CC) showed a nominal association with increased CHD risk: odds ratio = 1.321, 95% confidence interval (1.032-1.692), P = .027; adjusted q = 0.176.
- The other reported rs7069102, rs4746720, rs7895833, and rs3818292 comparisons were not associated with CHD risk.
Why it matters
The findings suggest that SIRT1 genetic variation, particularly rs7069102, may be relevant to differences in CHD susceptibility. However, the evidence is based on a limited set of studies, and the rs4746720 result illustrates the importance of accounting for multiple comparisons. These results are hypothesis-generating rather than a basis for individual risk assessment.
What to keep in mind
The authors note that the quantity and quality of included studies were limited, and that the conclusions require verification in more high-quality studies.