Anterior Chamber Depth Changes: After Phacoemulsification in Eyes With Pseudoexfoliation Syndrome Versus Control Eyes: A Systematic Review and Meta-analysis.

J Refract SurgNov 1, 2026 (epub)
Clinical ResearchOphthalmology

Constantine D Angelidis, Marios Katsimpras, Anastasia Tsiogka et al.

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In 30 seconds

This systematic review and meta-analysis compared anterior chamber depth (ACD) before and after phacoemulsification in eyes with pseudoexfoliation syndrome (PEX) and control eyes. Seven studies included 515 eyes: 232 with PEX and 283 controls. Preoperative ACD was narrower in PEX eyes, while postoperative ACD did not differ significantly between groups. The mean ACD change was greater in PEX eyes (weighted mean difference 0.252; 95% CI 0.169 to 0.336; P < .001). The authors suggest this difference may reflect zonulopathy and could affect effective lens position and refractive outcomes.

Key findings

  • Preoperative ACD was narrower in PEX eyes than controls (WMD = -0.140; 95% CI = -0.214 to -0.066; P < .001).
  • Postoperative ACD did not differ significantly between groups (WMD = 0.100; 95% CI = -0.021 to 0.221; P = .107).
  • ACD change was greater in PEX eyes (WMD = 0.252; 95% CI = 0.169 to 0.336; P < .001).

Why it matters

ACD is related to effective lens position, which is important for refractive prediction after cataract surgery. The greater postoperative ACD change observed in PEX eyes may signal a difference in lens position that could contribute to unexpected refractive results. The findings highlight a potential consideration when interpreting biometric measurements in this population.

What to keep in mind

The meta-analysis included seven studies, and the included studies were cohort studies rather than randomized trials.

Source

PubMed · PMID 42992810

Published in J Refract Surg. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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