Effect of Intravenous Acetaminophen on Preemptive Multimodal Analgesia for Pediatric Osteotomy Correction Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial.

Drug Des Devel TherOct 30, 2026 (epub)
Case ReportOrthopedic SurgeryAnesthesiologyPediatricsOpen access

Lei Wang, Lei Wu, Yi Zhu et al.

✦ AI-curated · Sources linked

Condensed from the publisher's abstract. An xxcode editorial summary of this publication has not been generated yet.

From the abstract

Children undergoing Osteotomy correction surgery can experience substantial postoperative pain and frequently require opioids. We evaluated whether a single preincision dose of intravenous acetaminophen, added to a standardized multimodal analgesic regimen, reduces postoperative pain and perioperative opioid requirements.

Reported results

Moderate-to-severe pain occurred in 8/48 (16.7%) versus 21/47 (44.7%) children, an absolute risk reduction of 28.0% (RR, 0.37; 95% CI, 0.2-0.8; P =0.004). Intraoperative remifentanil consumption was lower in the acetaminophen group (median, 0.8 vs 1.3 mg; between-group difference, 0.6 mg; 95% CI, 0.3-0.9; P <0.001).

Authors' conclusions

Preincision intravenous acetaminophen was associated with a lower incidence of moderate-to-severe postoperative pain and reduced opioid requirements in children undergoing osteotomy correction surgery. Larger multicenter trials are warranted to confirm these findings.

Source

PubMed · PMID 42984730Free full text on PubMed Central

Published in Drug Des Devel Ther. The text above is extracted from the publisher's own abstract and has not been edited by xxcode. For clinical decisions, review the original publication.

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