Vertebral Hemangioma Sparing in a 99m Tc-PSMA Superscan.

Clin Nucl MedOct 20, 2026 (epub)
Case ReportNuclear MedicineOncology (Medical)Radiology (Diagnostic)

Mohammad Ahmadi, Nikoo Rezaei, Fatemeh Taheri et al.

✦ AI-curated · Sources linked

Case in brief

A 60-year-old man with biopsy-proven prostate adenocarcinoma underwent 99mTc-PSMA scintigraphy while being evaluated for potential 177Lu-PSMA radioligand therapy. The scan showed diffuse skeletal tracer accumulation resembling a bone-scan superscan, with a focal photopenic defect in the thoracic spine. SPECT/CT localized the defect to a hemangioma in the T9 vertebral body. Imaging also showed an elongated, ventrally deviated, hook-like xiphoid process, interpreted as a benign anatomic variant.

What made this case unusual

The vertebral hemangioma appeared as a focal photopenic defect within diffuse skeletal 99mTc-PSMA uptake, an atypical distribution that could be misinterpreted without anatomic correlation.

Diagnostic / clinical pearl

Correlating functional 99mTc-PSMA findings with SPECT/CT anatomy can clarify focal photopenic defects and help avoid misinterpretation.

Source

PubMed · PMID 42912551

Published in Clin Nucl Med. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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