Normal age-related decline in forced vital capacity: a systematic review and meta-analysis.
Eur Respir RevSep 9, 2026 (epub)
Clinical ResearchPulmonology
Imran Satia, Katlyn Brown, Jody Filkowski et al.
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In 30 seconds
This systematic review and meta-analysis examined age-related changes in forced vital capacity (FVC) among over 365,000 adults without lung disease. The study found that FVC peaks in the mid-20s and declines continuously, with women experiencing a linear decline of approximately 26 mL·year -1 and men showing a biphasic decline of about 22 mL·year -1 before age 40 and 36 mL·year -1 thereafter.
Key findings
- FVC declines continuously after peaking in the mid-20s.
- Women experience a linear decline of approximately 26 mL·year -1.
- Men show a biphasic decline: 22 mL·year -1 before age 40 and 36 mL·year -1 thereafter.
- Estimates of FVC decline varied widely, ranging from 10 to 80 mL·year -1.
Why it matters
Understanding normative FVC trajectories is crucial for differentiating between healthy ageing and pathological lung decline, which can enhance diagnostic accuracy and inform treatment strategies in clinical practice.