Nasopharyngeal Carriage Rate, Risk Factors, and Co-Resistance Patterns of Methicillin-Resistant Staphylococcus aureus in Ethiopia: Systematic Review and Meta-Analysis.
Simachew Getaneh Endalamew, Sofiya Ayalew Kebede, Solomon Keflie Assefa et al.
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In 30 seconds
This systematic review and meta-analysis assessed the nasopharyngeal carriage rate of methicillin-resistant Staphylococcus aureus (MRSA) in Ethiopia, analyzing 20 studies with 6869 participants. The pooled prevalence of MRSA carriage was found to be 7.3% (95% CI, 5.0-10.8). The study also identified risk factors such as prior hospitalization and antibiotic use associated with increased carriage rates.
Key findings
- Pooled prevalence of MRSA carriage was 7.3% (95% CI, 5.0-10.8).
- Resistance to tetracycline was highest at 55.75%, while clindamycin resistance was lowest at 12.66%.
- Prior hospitalization was associated with increased odds of MRSA carriage (OR, 3.49).
- Antibiotic use also increased the odds of carriage (OR, 2.35).
Why it matters
Understanding the prevalence and risk factors for MRSA carriage is crucial for developing effective infection control strategies. This study highlights the need for enhanced surveillance and antimicrobial stewardship to mitigate MRSA transmission and associated health risks.
What to keep in mind
Inconsistent variable coding across studies limited the inclusion of other potential risk factors.