Improvement in Delusional Jealousy and Caregiver Distress After Switching From Oral Galantamine to a Donepezil Transdermal Patch in Alzheimer's Disease: A Case Report.
Hitomi Matsui, Yuki Omori, Ko Furuta
✦ AI-curated · Sources linked
Case in brief
A woman in her 60s with probable Alzheimer's disease experienced caregiver-reported delusional jealousy and marital conflicts while on oral galantamine. After switching to a donepezil transdermal patch, her delusional jealousy significantly improved, with a reduction in conflict frequency and caregiver distress. By six months post-switch, delusional jealousy had nearly resolved, although some negative self-appraisals persisted. No other psychotropic medications were adjusted during this period.
Diagnostic / clinical pearl
Switching from oral galantamine to a donepezil transdermal patch may alleviate delusional jealousy and reduce caregiver distress in Alzheimer's disease, highlighting the potential benefits of changing cholinesterase inhibitors.