Outcomes and learning curve of single-kidney transplantation from small pediatric donors in children: a retrospective cohort study with meta-analysis.
Pediatr Surg IntSep 6, 2026 (epub)
Zaohang Yan, Chengjun Yu, Jie Zhang et al.
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In 30 seconds
This retrospective cohort study evaluated outcomes of single-kidney transplantation from small pediatric donors in 77 children. The small-donor group exhibited significantly lower 1-year graft survival (73.1% vs 100%, P<0.001) and higher acute rejection rates (19.2% vs 2.0%, P=0.026) compared to large-donor recipients. A meta-analysis of seven studies supported these findings.
Key findings
- 1-year graft survival was 73.1% for small-donor recipients compared to 100% for large-donor recipients.
- Acute rejection rates were significantly higher in the small-donor group at 19.2% versus 2.0% in the large-donor group.
- The meta-analysis reported a 1-year patient survival rate of 98% and graft survival of 91%.
Why it matters
Understanding the outcomes of single-kidney transplantation from small pediatric donors is crucial for clinicians to assess the risks and benefits of this approach, particularly in terms of graft survival and rejection rates.