Single-fraction stereotactic radiosurgery vs. hypofractionated stereotactic radiotherapy for resected brain metastases: a systematic review and meta-analysis of comparative studies.
Neurosurg RevSep 5, 2026 (epub)
Alireza Shariati, Arya Khezrpour, Taher Fanihagh et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the effectiveness of single-fraction stereotactic radiosurgery (SF-SRS) versus hypofractionated stereotactic radiotherapy (HF-SRT) in adults with resected brain metastases. Analyzing data from seven studies involving 589 patients, the findings indicated that SF-SRS had marginally higher local control at 6 months (RR 1.05, 95% CI 1.01-1.09, p=0.006), although differences may be influenced by baseline imbalances.
Key findings
- At 6 months, local control was marginally higher with SF-SRS than HF-SRT (RR 1.05, 95% CI 1.01-1.09, p=0.006).
- The 12-month local control analysis showed a non-significant trend favoring SF-SRS (RR 1.06, 95% CI 0.99-1.14, p=0.08).
- No significant difference in 12-month overall survival between SF-SRS and HF-SRT (RR 1.08, 95% CI 0.82-1.41, p=0.59).
Why it matters
Understanding the comparative effectiveness of SF-SRS and HF-SRT is crucial for optimizing postoperative care in patients with brain metastases, as local control can impact overall treatment outcomes.