Association between vitamin D deficiency and chronic kidney disease progression: A GRADE-based dose-response systematic review and meta-analysis.
Sayed Yousef Mojtahedi, Mohsen Sedighiyan, Paniz Pourpashang
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In 30 seconds
This systematic review and dose-response meta-analysis evaluated the link between vitamin D deficiency and chronic kidney disease (CKD) progression across 11 studies. The findings indicated that vitamin D deficiency was associated with a 33% increase in the odds of CKD progression (OR = 1.33, 95% CI: 1.06-1.67; P = .019), although significant heterogeneity was noted among studies.
Key findings
- Vitamin D deficiency was associated with 33% higher odds of CKD progression (OR = 1.33, 95% CI: 1.06-1.67; P = .019).
- A dose-response analysis indicated a 1.18 odds increase for CKD progression per 10 ng/mL lower 25(OH)D concentration (95% CI: 1.09-1.25).
- Stronger associations were found in studies with long-term follow-up (≥5 years; OR = 2.07, 95% CI: 1.29-3.14; P = .001).
- High-quality studies showed an OR of 1.35 for CKD progression associated with vitamin D deficiency (95% CI: 1.06-1.69; P = .03).
Why it matters
Understanding the relationship between vitamin D levels and CKD progression is crucial for clinicians, as it may inform future guidelines on monitoring and managing vitamin D status in patients with kidney disease.
What to keep in mind
The evidence was rated as very low certainty due to the observational nature of the studies and substantial heterogeneity.