Combination of Multiple-Dose Activated Charcoal and Infusion Therapy That Led to Favorable Outcomes in Colchicine Poisoning: A Case Report.
Manabu Eiraku, Kazuyuki Miyamoto, Keisuke Suzuki et al.
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Case in brief
A man in his 20s presented with gastrointestinal symptoms and dyspnea after ingesting dried Colchicum autumnale bulbs containing colchicine. He received multiple-dose activated charcoal and high-volume fluid infusion, along with hemodialysis and hemodiafiltration. Serum colchicine levels were monitored, showing a decrease after treatment initiation, although a secondary rise occurred post-hemodiafiltration. The patient had favorable outcomes following this comprehensive management approach.
Diagnostic / clinical pearl
Monitoring serum and urine colchicine levels can provide valuable insights into the pharmacokinetics of colchicine poisoning and the effectiveness of treatment interventions.
Why it matters
This case highlights the importance of understanding the toxicokinetics of colchicine and the potential benefits of combined therapeutic strategies in managing severe poisoning.