Randomised controlled trial to assess the safety and efficiency of a self-contained sampling device/disposable bronchoscope system versus usual sampling procedure (RASECAL).
BMJ Open Respir ResAug 31, 2026 (epub)
Suveer Singh, Sanjeet Chana, James Mcentee et al.
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In 30 seconds
This multicenter randomized controlled trial evaluated the safety and efficiency of a closed bronchoscopy sampling system (Ambu bronchosampler) compared to standard sampling containers in 188 mechanically ventilated patients. The closed system demonstrated significant safety improvements, with spills at 0% versus 23.7% and unplanned disconnections at 5.3% versus 21.3%, both with p<0.001.
Key findings
- Spills occurred in 0% of the closed system group versus 23.7% in the standard group, p<0.001.
- Unplanned tube disconnections were 5.3% for the closed system compared to 21.3% for standard containers, p<0.001.
- Sample loss was significantly lower in the closed system at 11.6% versus 48.4%, p<0.001.
- Setup ease was rated acceptable or very easy in 98.9% of closed system cases versus 82.8% for standard containers.
Why it matters
The findings suggest that using a closed bronchoscopy sampling system can enhance patient safety and procedural efficiency, potentially leading to better diagnostic outcomes in mechanically ventilated patients.